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Drug-Target Interaction

Drug

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PubChem ID:8987
Structure:
Synonyms:
147-84-2
148-18-5
148-18-5 (hydrochloride salt)
148-18-5 (SODIUM SALT)
17156-83-1
20624-25-3
20624-25-3 (hydrochloride salt, trihydrate)
20624-25-3 (SODIUM SALT TRIHYDRATE)
21124-33-4
21124-33-4 (ammonium salt)
34464-51-2
34464-51-2 (bismuth salt)
3699-30-7
3699-30-7 (potassium-salt)
4-04-00-00389 (Beilstein Handbook Reference)
942650-37-5
AC1L1S2S
AC1Q7EOM
AIDS-000134
AIDS000134
AR-1I5151
BRN 1747741
C19150
C5H11NS2
Carbamic acid, diethyldithio-
Carbamodithioic acid, diethyl-
Carbamodithioic acid, N,N-diethyl-
CCG-35356
CCRIS 7364
CHEBI:41796
CHEMBL961
Cupral
DB02520
DCD
DETC
Diethyl dithiocarbamate
DIETHYL DITHIOCARBAMIC ACID
diethylaminomethanedithioic acid
Diethylcarbamodithioic acid
Diethyldithiocarbamate
Diethyldithiocarbamic acid
Diethyldithione
Dithiocarb
Ditiocarb
Ditiocarb, Sodium Salt
Ditiocarb, Zinc Salt
DTC
EINECS 205-701-7
Imuthiol
LS-49308
NCGC00166328-01
NCI60_004156
NCIMech_000185
NSC4857
OPC-12759
Sodium Diethyldithiocarbamate
Thiocarb
Zinc Diethyldithiocarbamate
ZINC03633221

Target

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Uniprot ID:Q7M053_RAT
Synonyms:
Aldehyde dehydrogenase
EC-Numbers:1.-.-.-
Organism:Rat
Rattus norvegicus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

2994256
Effect of alcohol and aldehyde dehydrogenase inhibitors on the toxicity of 3-nitropropanol in rats.. M A Pass; A D Muir; W Majak; G S Yost (1985) Toxicology and applied pharmacology display abstract
The nitrocompounds 3-nitropropanol (NPOH) and 3-nitropropionic acid (NPA) were shown to be equally toxic when injected intraperitoneally into male Wistar rats. The LD50 for NPOH was 0.58 mmol/kg and for NPA it was 0.56 mmol/kg. NPOH was rapidly metabolized to NPA but this conversion was suppressed by prior administration of ethanol or 4-methylpyrazole to inhibit alcohol dehydrogenase. Administration of ethanol or 4-methylpyrazole before NPOH protected rats from intoxication. However, if the alcohol dehydrogenase inhibitors were given after the nitroalcohol, toxicity still occurred. Administration of the aldehyde dehydrogenase inhibitor diethyldithiocarbamic acid had little effect on the conversion of NPOH to NPA and did not alter the toxicity of NPOH. It was concluded that NPOH and NPA are equally toxic to rats but that NPOH is toxic due to its being rapidly converted to NPA.