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Drug-Target Interaction

Drug

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PubChem ID:82146
Structure:
Synonyms:
153559-49-0
3-methyl-TTNEB
4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethenyl)benzoic acid
4-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl)benz
4-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl)benzoic acid
4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid
4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid
4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic acid
4-[1-3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthaleneyl)vinyl]benzene carboxylic acid
9RA
Benzoic acid, 4-(1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl)-
Bexarotene
Bexarotene (USAN/INN)
Bexarotene [USAN]
C095105
C24H28O2
CHEBI:50859
D03106
DB00307
Elan brand of bexarotene
HSDB 7453
LG 1069
LG-100069
LG100069
LG1069
LG69 compound
LGD 1069
LGD-1069
LGD1069
Ligand brand of bexarotene
LS-38306
NCGC00181016-01
p-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl)benzoic acid
Targretin
Targretin (TN)
Targretyn
Targrexin
TRG
ATC-Codes:
Side-Effects:
Side-EffectFrequency
rash0.335
pruritus0.27
pain0.24000001
contact dermatitis0.11
infection0.09
headache0.07
paresthesia0.06
edema0.05
hyperlipemia0.05
cough0.03
sweating0.03
leukopenia0.03
peripheral edema0.03
exfoliative dermatitis0.03
pharyngitis0.03
lymphadenopathy0.03
asthenia0.03
syncope0
skin ulcer0
tachycardia0
spasm0
chills0
cerebrovascular accident0
skin nodule0
breast pain0
melena0
nausea0
neutropenia0
otitis0
otitis externa0
pancreatitis0
hemoptysis0
pleural effusion0
pneumonia0
pulmonary edema0
visual field defect0
rhinitis0
thrombocytopenia0
ulcer0
sgot increased0
dry skin0
myalgia0
right heart failure0
hypoxia0
sepsis0
dry eyes0
neuropathy0
acne0
thrombocythemia0
insomnia0
bone pain0
lactic dehydrogenase increased0
amylase increased0
erythema0
urinary incontinence0
urinary tract infection0
vomiting0
weight gain0
weight loss0
dry mouth0
hepatic failure0
urinary urgency0
agitation0
cataract0
allergic reaction0
lymphocytosis0
abdominal pain0
chest pain0
colitis0
confusion0
conjunctivitis0
constipation0
constitutional symptoms0
dermatitis0
type 2 diabetes0
diarrhea0
dizziness0
dyspepsia0
cellulitis0
blepharitis0
bacterial infections0
acute pancreatitis0
albuminuria0
alopecia0
anemia0
hypochromic anemia0
angina pectoris0
anorexia0
arrhythmia0
arthralgia0
ataxia0
back pain0
dyspnea0
dysuria0
hyperkalemia0
hypernatremia0
hypersensitivity0
hypertension0
hypertriglyceridemia0
hypocalcemia0
hyponatremia0
hypothyroidism0
bronchitis0
influenza0
arthrosis0
hyperglycemia0
hyperesthesia0
hypercholesterolemia0
ear pain0
eosinophilia0
fatigue0
fever0
flatulence0
gastroenteritis0
gingivitis0
subdural hematoma0
hematuria0
hemorrhage0
bilirubinemia0
keratitis0

Target

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Uniprot ID:CP2C9_HUMAN
Synonyms:
(R)-limonene 6-monooxygenase
(S)-limonene 6-monooxygenase
(S)-limonene 7-monooxygenase
CYPIIC9
Cytochrome P450 2C9
P-450MP
P450 MP-4/MP-8
P450 PB-1
S-mephenytoin 4-hydroxylase
EC-Numbers:1.14.13.48
1.14.13.49
1.14.13.80
Organism:Homo sapiens
Human
PDB IDs:1OG2 1OG5 1R9O
Structure:
1R9O

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: