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Drug-Target Interaction

Drug

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PubChem ID:7847
Structure:
Synonyms:
01679_FLUKA
01680_FLUKA
107-02-8
110221_ALDRICH
2 Propenal
2-Propen-1-one
2-Propenal
2-Propenal, homopolymer
25068-14-8
25314-61-8
5S06230_SUPELCO
AB1003461
AC1L1POR
AC1Q2A9V
Acquinite
Acraldehyde
Acraldehydeacroleina
Acraldehydeacroleina [Italian]
Acrolein
Acrolein, inhibited
Acrolein, inhibited [UN1092] [Poison]
Acrolein, inhibited [UN1092] [Poison]
Acroleina
Acroleina [Italian]
Acroleine
Acroleine [Dutch, French]
Acrylaldehyd
Acrylaldehyd [German]
Acrylaldehyde
Acrylic aldehyde
Acrylic aldehyde, inhibited
Aerolein
AI3-24160
AKOS000120766
Akrolein
Akrolein [Czech]
Akroleina
Akroleina [Polish]
Aldehyde acrylique
Aldehyde acrylique [French]
Aldehyde, Acrylic
Aldehyde, Allyl
Aldehyde, Ethylene
Aldeide acrilica
Aldeide acrilica [Italian]
Allyl aldehyde
Aqualin
Aqualine
Biocide
C01471
Caswell No. 009
CCRIS 3278
CHEBI:15368
CHEMBL721
Crolean
D000171
EINECS 203-453-4
EPA Pesticide Chemical Code 000701
Ethylene aldehyde
HSDB 177
I14-6377
LS-422
LTBB002013
Magnacide
Magnacide H
Magnacide H and B
MolPort-001-779-683
NCGC00091484-01
NCGC00091484-02
NSC 8819
NSC8819
Papite
polyacrolein
prop-2-en -1-al
Prop-2-en-1-al
prop-2-enal
Propenal
Propenal [Czech]
Propenal, inhibited
Propenaldehyde
Propylene aldehyde
RCRA waste no. P003
RCRA waste number P003
Slimicide
trans-Acrolein
UN 1092
UN1092
WLN: VH1U1

Target

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Uniprot ID:ICE_DROME
Synonyms:
Caspase
drICE
EC-Numbers:3.4.22.-
Organism:Drosophila melanogaster
Fruit fly
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

11504702
Inhibition of neutrophil apoptosis by acrolein: a mechanism of tobacco-related lung disease?. E I Finkelstein; M Nardini; A van der Vliet (2001) American journal of physiology. Lung cellular and molecular physiology display abstract
Cigarette smoking is known to contribute to inflammatory diseases of the respiratory tract by promoting recruitment of inflammatory-immune cells such as neutrophils and perhaps by altering neutrophil functional properties. We investigated whether acrolein, a toxic unsaturated aldehyde found in cigarette smoke, could directly affect neutrophil function. Exposure of freshly isolated human neutrophils to acrolein markedly inhibited spontaneous neutrophil apoptosis as indicated by loss of membrane asymmetry and DNA fragmentation and induced increased neutrophil production of the chemokine interleukin-8 (IL-8). Acrolein (1--50 microM) was found to induce marked activation of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinases (MAPKs), and inhibition of p38 MAPK activation by SB-203580 prevented acrolein-induced IL-8 release. However, inhibition of either ERK or p38 MAPK did not affect acrolein-dependent inhibition of apoptosis. Acrolein exposure prevented the activation of caspase-3, a crucial step in the execution of neutrophil apoptosis, presumably by direct inhibition of the enzyme. Our results indicate that acrolein may contribute to smoke-induced inflammatory processes in the lung by increasing neutrophil recruitment and reducing neutrophil clearance by apoptosis.