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Drug-Target Interaction

Drug

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PubChem ID:72440
Structure:
Synonyms:
15475-56-6
4-Amino-10-methylfolic acid
4-Amino-N(sup 10)-methylpteroylglutamic acid
4-Aminomethylpteroylglutamic acid
51865-79-3
59-05-2
7413-34-5
A-Methopterin
A-Methpterin
AI3-25299
AIDS-006953
AIDS006953
Amethopterin L-
Antifolan
C20H22N8O5
CAS-59-05-2
CAS-59-05-2-Batch2
CCRIS 1109
CL-14377
D-(-)-N-(2,4-Diamino-6-pteridinyl(dimethylamino)benzoyl)glutamic acid
D-Amethopterin
D-glutamic acid, N-(4-(((2,4-diamino-6-pteridyl)methyl)methylamino)benzoyl)-
D-Glutamic acid, N-[4-[[(2,4-diamino-6- pteridinyl)methyl][methyl]amino]benzoyl]-
D-Methotrexate
DRG-0024
EINECS 200-413-8
EINECS 257-482-2
EMT 25,299
Folex-Pfs
Glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-, D-
Glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-, L-
Hdmtx
HSDB 3123
Kyselina 4-amino-N(sup 10)-methylpteroylglutamova [Czech]
Kyselina N-(p-((2,4-diamino-6-pteridinylmethyl)methylamino)benzoyl)-L-glutamova [Czech]
l-()-n-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)glutamic acid
L-(+)-N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)glutamic acid
L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-
Ledertrexate
Lopac-A-6770
Lopac-A-9898
Lopac0_000095
LS-71810
Metatrexan
Methotrexat-Ebewe
METHOTREXATE
Methotrexate analog
Methotrexate [USAN:BAN:INN:JAN]
Methotrexate, (D)-Isomer
Methotrexate, L-
Methotrexatum
Methotrexatum [INN-Latin]
Methylaminopterinum
Metotressato [DCIT]
Metotrexato
Metotrexato [INN-Spanish]
Mexate
MTX
N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-D-glutamic
N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-D-glutamic acid
N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamicacid
n-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-l-()-glutamic acid
N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-(+)-glutamic acid
N-(p-(((2,4-Diamino-6-pteridyl)methyl)methylamino)benzoyl)glutamic acid
N-Bismethylpteroylglutamic acid
NCGC00015079-01
NCGC00015079-02
NCGC00016264-01
NCGC00016264-02
NCI-C04671
NSC 117356
NSC 740
NSC-740
NSC117356
R 9985
Rheumatrex
TCMDC-125488
X 133
ATC-Codes:

Target

show target details
Uniprot ID:TYSY_LACCA
Synonyms:
Thymidylate synthase
TS
TSase
EC-Numbers:2.1.1.45
Organism:Lactobacillus casei
PDB IDs:1BO7 1BO8 1BP0 1BP6 1BPJ 1JMF 1JMG 1JMH 1JMI 1LCA 1LCB 1LCE 1NJA 1NJB 1NJC 1NJD 1NJE 1TDA 1TDB 1TDC 1THY 1TSL 1TSM 1TSV 1TSW 1TSX 1TSY 1TSZ 1TVU 1TVV 1TVW 1VZA 1VZB 1VZC 1VZD 1VZE 2G86 2G89 2G8A 2G8D 2TDD 2TDM 3BNZ 3BYX 3BZ0 3C06 3C0A 4TMS
Structure:
4TMS

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
--120000-

References: