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Drug-Target Interaction

Drug

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PubChem ID:72300
Structure:
Synonyms:
(1,1'-Biphenyl)-2,2'-diol, 5,5'-di-2-propenyl-
2,2'-Bichavicol
2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol
5,5'-di(prop-2-en-1-yl)biphenyl-2,2'-diol
5,5'-Di-2-propenyl-[1,1'-biphenyl]-2,2'-diol
5,5'-Diallyl-2,2'-biphenyldiol
5,5'-Diallyl-2,2'-dihydroxybiphenyl
528-43-8
AC-931
AC1L2HT7
AC1Q7B1V
AIDS-002239
AIDS002239
AR-1D1103
BB_NC-1463
Bio-0675
BRD-K26168087-001-01-4
C10651
C18H18O2
CHEMBL180920
Dehydrodichavicol
HMS2269N09
I01-2281
LS-44356
M3445_SIGMA
Magnolol
Magnolol, 2,2'-Bichavicol
Magnolol-Supplied by Selleck Chemicals
MLS001048917
MolPort-002-507-434
NCGC00161609-01
NCGC00161609-02
NSC 293099
NSC293099
S2321_Selleck
SMP2_000086
SMR000387108
STK801955
UPCMLD-DP037
UPCMLD-DP037:001
ZINC00001645

Target

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Uniprot ID:Q9Y354_HUMAN
Synonyms:
Matrix metalloproteinase 9
EC-Numbers:3.4.24.35
Organism:Homo sapiens
Human
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

11731909
Inhibitory effect of magnolol and honokiol from Magnolia obovata on human fibrosarcoma HT-1080. Invasiveness in vitro.. H Nagase; K Ikeda; Y Sakai (2001) Planta medica display abstract
We investigated the inhibitory effect of Magnolia obovata Thunb. bark ethanol extracts on human fibrosarcoma HT-1080 cells invasion in a reconstituted basement membrane [Matrigel (MG)]. We found that the effective components of the bark ethanol extracts were magnolol and honokiol, two biphenyl compounds. The extracts, magnolol and honokiol, did not affect HT-1080 cells adhesion to MG, but did inhibit HT-1080 cells migration at a high concentration (100 microM). HT-1080 cells secrete matrix metalloproteinase (MMP)-9, which degrades the extracellular matrix as a part of the invasive process. Magnolol and honokiol inhibited the activity of MMP-9, which may have been responsible, in part, for the inhibition of tumor cell invasiveness.