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Drug-Target Interaction

Drug

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PubChem ID:71771
Structure:
Synonyms:
(2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetoxy)acetic acid
2-((2,6-Dichlorophenyl)amino)benzeneacetic acid carboxymethyl ester
2-((2,6-dichlorophenyl)amino)phenylacetoxyacetic acid
2-(o-(2,6-Dichloranilino)phenylacetoxy)essigsaeure
2-[2-[2-(2,6-dichloroanilino)phenyl]acetyl]oxyacetic acid
89796-99-6
954-67-6
AC-5282
AC1L2GS7
AC1Q3RRC
AC1Q3RRD
Aceclofenac
Aceclofenac (JAN/INN)
Aceclofenac (TN)
Aceclofenac [BAN:INN]
Aceclofenaco
Aceclofenaco [Spanish]
Aceclofenacum
Aceclofenacum [Latin]
Airtal
Airtal Difucrem
Aital
Almirall brand of aceclofenac
AR-1A2017
BB_SC-2095
Benzeneacetic acid, 2-((2,6-dichlorophenyl)amino)-, carboxymethyl ester
Beofenac
Biofenac
BPBio1_000077
BRD-K68538666-001-03-2
Bristaflam
Bristol-Myers Squibb brand of aceclofenac
BRN 4884476
BSPBio_000069
C056498
C16H13Cl2NO4
CAS-89796-99-6
CHEMBL93645
D01545
Falcol
Falcol Difucrem
Farma Lepori brand of aceclofenac
Gerbin
Gerbin Difucrem
Glycolic acid, (o-(2,6-dichloroanilino)phenyl)acetate (ester)
HMS1568D11
HMS2090G07
HMS2095D11
HMS2231B03
I01-1305
ICN brand of aceclofenac
KST-1A9120
LS-28738
MLS001032069
MLS001304028
MLS002154226
MolPort-001-727-410
NCGC00016957-01
NCGC00016957-02
NCGC00016957-03
Preservex
Prestwick0_000175
Prestwick1_000175
Prestwick2_000175
Prestwick3_000175
Prestwick_772
Sanein
SMR000718629
SPBio_001990
STK594349
TL8005786
UCB brand of aceclofenac
UNII-RPK779R03H
[({2-[(2,6-dichlorophenyl)amino]phenyl}acetyl)oxy]acetic acid
ATC-Codes:

Target

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Uniprot ID:Q6LCE7_HUMAN
Synonyms:
Cyclooxygenase-1
EC-Numbers:1.14.99.1
Organism:Homo sapiens
Human
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

9226412
Aceclofenac blocks prostaglandin E2 production following its intracellular conversion into cyclooxygenase inhibitors.. R Yamazaki; S Kawai; T Matsuzaki; N Kaneda; S Hashimoto; T Yokokura; R Okamoto; T Koshino; Y Mizushima (1997) European journal of pharmacology display abstract
Aceclofenac, 2-[(2,6-dichlorophenyl) amino] phenylacetoxyacetic acid, is a novel non-steroidal anti-inflammatory drug. We investigated the effects of aceclofenac on prostaglandin E2 production by several kinds of human cells. Aceclofenac inhibited interleukin-1beta-induced prostaglandin E2 production by human rheumatoid synovial cells, but had no inhibitory effect on cyclooxygenase-1 or cyclooxygenase-2 activities by itself. We also observed that part of the aceclofenac was converted into diclofenac, the cyclooxygenase-1 and cyclooxygenase-2 inhibitor, when aceclofenac was incubated with human rheumatoid synovial cells. Aceclofenac was also converted into diclofenac and 4'-hydroxy diclofenac by human polymorphonuclear leukocytes and monocytes. 4'-Hydroxy diclofenac suppressed prostaglandin E2 production specifically by blocking cyclooxygenase-2 activity. These findings suggested that aceclofenac can be metabolized to cyclooxygenase inhibitors (diclofenac and/or 4'-hydroxy diclofenac) by these inflammatory cells. Although detailed examinations in non-inflammatory cells remain to be studied, we concluded that aceclofenac is shown to be a new type of non-steroidal anti-inflammatory drug which is intracellulary converted into active metabolites that inhibit the prostaglandin E2 production.