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Drug-Target Interaction

Drug

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PubChem ID:712
Structure:
Synonyms:
104512-58-5
104512-63-2
104814-22-4
112068-71-0
12795-06-1
15512_RIEDEL
15512_SIAL
15513_RIEDEL
15513_SIAL
158127_SIAL
1HG84L3525
252549_SIAL
30525-89-4
33220_RIEDEL
33220_SIAL
441244_ALDRICH
47083U_SUPELCO
50-00-0
53026-80-5
533998_ALDRICH
533998_SIAL
8005-38-7
8006-07-3
8013-13-6
a carbonyl group
AB1002009
AB1002010
AC1L19UQ
AI3-26806
AIDS-186245
AIDS186245
ALCOHOL-GROUP
Aldacide
aldehido
aldehidos
Aldehyd
Aldehyd mravenci
Aldehyd mravenci [Czech]
aldehyde
Aldehyde formique
Aldehyde formique [French]
Aldehyde formique [ISO-French]
aldehydes
aldehydum
Aldeide formica
Aldeide formica [Italian]
an alcohol group
an aldehyde
BFV
BIDD:ER0493
bmse000256
C00067
c0122
C12942
C3H8O
CARBON MONOXIDE
Carbon oxide
Carbon oxide (CO)
CARBONYL-GROUP
Caswell No. 465
Caswell No. 633
CCRIS 315
cetone
CHEBI:16842
CHEBI:17087
CHEBI:17478
CHEBI:18044
CHEMBL1255
CMO
D00017
D005557
D01494
DB03843
dialkyl ketone
dialkyl ketones
Dormol
EINECS 200-001-8
EPA Pesticide Chemical Code 043001
EPA Pesticide Chemical Code 043002
F-gen
F15587_ALDRICH
F1635_SIAL
F1635_SIGMA
F8775_SIGMA
FA
Fannoform
Flo-Mor
Floguard 1015
FM 282
FOR
Fordor
Formagene
Formaldehyd
Formaldehyd [Czech, Polish]
FORMALDEHYDE
Formaldehyde (gas)
Formaldehyde (USP)
FORMALDEHYDE 37%
Formaldehyde polymer
Formaldehyde solution
Formaldehyde [BSI:ISO]
Formaldehyde, 37%, methanol-free
FORMALDEHYDE, ACS
Formaldehyde, as formalin solution
Formaldehyde, gas
Formaldehyde, solution
Formaldehyde, solution (37% to 50%)
Formaldehyde, solution, flammable
Formaldehyde, solutions (Formalin) (corrosive)
Formaldehyde, solutions with not <25% formaldehyde [UN2209] [Corrosive]
Formaldehyde, solutions with not <25% formaldehyde [UN2209] [Corrosive]
Formaldehyde, solutions, flammable [UN1198] [Flammable liquid]
Formaldehyde, solutions, flammable [UN1198] [Flammable liquid]
formalin
Formalin (JP15)
Formalin (JP16)
Formalin 40
Formalin solution, neutral buffered, 10%
Formalin-loesungen
Formalin-loesungen [German]
Formalina
Formalina [Italian]
Formaline
Formaline [German]
Formalith
Formic aldehyde
Formic aldehyde
formol
FORMYL GROUP
FYDE
HCHO
HOCH
HSDB 164
HSDB 4070
HT501128_SIGMA
HT5011_SIGMA
HT5012_SIGMA
HT501320_SIGMA
HT5014_SIGMA
HT501640_SIGMA
HT501850_SIGMA
Hyperband
Hyperband (TN)
Ivalon
Karsan
Keton
ketone
ketones
LS-101266
LS-134
Lysoform
Melamine-Formaldehyde Resin
metaformaldehyde
Methaldehyde
Methan 21
methanal
Methyl aldehyde
methylene glycol
Methylene oxide
MolPort-001-785-627
Morbicid
nchem.467-comp1
nchembio.123-comp9
nchembio.146-comp5
nchembio.172-comp3
NCI-C02799
NSC 298885
NSC298885
Oilstop, Halowax
Oplossingen
Oplossingen [Dutch]
Oxomethane
Oxomethylene
Oxymethylene
P0018
P6148_SIAL
Paraform
PARAFORMALDEHYDE
Paraformaldehyde (JP15)
Paraformaldehyde (JP16)
Paraformaldehyde [JAN]
Paraformaldehyde [UN2213] [Flammable solid]
Paraformaldehyde [UN2213] [Flammable solid]
Paraformaldehyde, polymer
Paraformaldehydum
Paraformic aldehyde
Poly(oxymethylene)
Polyformaldehyde
Polymerised formaldehyde
Polyoxymethylene
Polyoxymethylene glycol
R-CO-R'
RC(=O)H
RCRA waste no. U122
RCRA waste number U122
RFPDT@
Superlysoform
UN 1198
UN 2209 (formalin)
UN1198
UN2209
UN2213
UNII-1HG84L3525
Veracur
WLN: VHH

Target

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Uniprot ID:HMOX1_HUMAN
Synonyms:
Heme oxygenase 1
HO-1
EC-Numbers:1.14.99.3
Organism:Homo sapiens
Human
PDB IDs:1N3U 1N45 1NI6 1OYK 1OYL 1OZE 1OZL 1OZR 1OZW 1S13 1S8C 1T5P 1TWN 1TWR 1XJZ 1XK0 1XK1 1XK2 1XK3 3CZY 3HOK
Structure:
3HOK

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

18289071
Cerebroprotective functions of HO-2.. Helena Parfenova; Charles W Leffler (2008) Current pharmaceutical design display abstract
The constitutive isoform of heme oxygenase, HO-2, is highly expressed in the brain and in cerebral vessels. HO-2 functions in the brain have been evaluated using pharmacological inhibitors of the enzyme and HO-2 gene deletion in in vivo animal models and in cultured cells (neurons, astrocytes, cerebral vascular endothelial cells). Rapid activation of HO-2 via post-translational modifications without upregulation of HO-2 expression or HO-1 induction coincides with the increase in cerebral blood flow aimed at maintaining brain homeostasis and neuronal survival during seizures, hypoxia, and hypotension. Pharmacological inhibition or gene deletion of brain HO-2 exacerbates oxidative stress induced by seizures, glutamate, and inflammatory cytokines, and causes cerebral vascular injury. Carbon monoxide (CO) and bilirubin, the end products of HO-catalyzed heme degradation, have distinct cytoprotective functions. CO, by binding to a heme prosthetic group, regulates the key components of cell signaling, including BK(Ca) channels, guanylyl cyclase, NADPH oxidase, and the mitochondria respiratory chain. Cerebral vasodilator effects of CO are mediated via activation of BK(Ca) channels and guanylyl cyclase. CO, by inhibiting the major components of endogenous oxidant-generating machinery, NADPH oxidase and the cytochrome C oxidase of the mitochondrial respiratory chain, blocks formation of reactive oxygen species. Bilirubin, via redox cycling with biliverdin, is a potent oxidant scavenger that removes preformed oxidants. Overall, HO-2 has dual housekeeping cerebroprotective functions by maintaining autoregulation of cerebral blood flow aimed at improving neuronal survival in a changing environment, and by providing an effective defense mechanism that blocks oxidant formation and prevents cell death caused by oxidative stress.