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Drug-Target Interaction

Drug

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PubChem ID:712
Structure:
Synonyms:
104512-58-5
104512-63-2
104814-22-4
112068-71-0
12795-06-1
15512_RIEDEL
15512_SIAL
15513_RIEDEL
15513_SIAL
158127_SIAL
1HG84L3525
252549_SIAL
30525-89-4
33220_RIEDEL
33220_SIAL
441244_ALDRICH
47083U_SUPELCO
50-00-0
53026-80-5
533998_ALDRICH
533998_SIAL
8005-38-7
8006-07-3
8013-13-6
a carbonyl group
AB1002009
AB1002010
AC1L19UQ
AI3-26806
AIDS-186245
AIDS186245
ALCOHOL-GROUP
Aldacide
aldehido
aldehidos
Aldehyd
Aldehyd mravenci
Aldehyd mravenci [Czech]
aldehyde
Aldehyde formique
Aldehyde formique [French]
Aldehyde formique [ISO-French]
aldehydes
aldehydum
Aldeide formica
Aldeide formica [Italian]
an alcohol group
an aldehyde
BFV
BIDD:ER0493
bmse000256
C00067
c0122
C12942
C3H8O
CARBON MONOXIDE
Carbon oxide
Carbon oxide (CO)
CARBONYL-GROUP
Caswell No. 465
Caswell No. 633
CCRIS 315
cetone
CHEBI:16842
CHEBI:17087
CHEBI:17478
CHEBI:18044
CHEMBL1255
CMO
D00017
D005557
D01494
DB03843
dialkyl ketone
dialkyl ketones
Dormol
EINECS 200-001-8
EPA Pesticide Chemical Code 043001
EPA Pesticide Chemical Code 043002
F-gen
F15587_ALDRICH
F1635_SIAL
F1635_SIGMA
F8775_SIGMA
FA
Fannoform
Flo-Mor
Floguard 1015
FM 282
FOR
Fordor
Formagene
Formaldehyd
Formaldehyd [Czech, Polish]
FORMALDEHYDE
Formaldehyde (gas)
Formaldehyde (USP)
FORMALDEHYDE 37%
Formaldehyde polymer
Formaldehyde solution
Formaldehyde [BSI:ISO]
Formaldehyde, 37%, methanol-free
FORMALDEHYDE, ACS
Formaldehyde, as formalin solution
Formaldehyde, gas
Formaldehyde, solution
Formaldehyde, solution (37% to 50%)
Formaldehyde, solution, flammable
Formaldehyde, solutions (Formalin) (corrosive)
Formaldehyde, solutions with not <25% formaldehyde [UN2209] [Corrosive]
Formaldehyde, solutions with not <25% formaldehyde [UN2209] [Corrosive]
Formaldehyde, solutions, flammable [UN1198] [Flammable liquid]
Formaldehyde, solutions, flammable [UN1198] [Flammable liquid]
formalin
Formalin (JP15)
Formalin (JP16)
Formalin 40
Formalin solution, neutral buffered, 10%
Formalin-loesungen
Formalin-loesungen [German]
Formalina
Formalina [Italian]
Formaline
Formaline [German]
Formalith
Formic aldehyde
Formic aldehyde
formol
FORMYL GROUP
FYDE
HCHO
HOCH
HSDB 164
HSDB 4070
HT501128_SIGMA
HT5011_SIGMA
HT5012_SIGMA
HT501320_SIGMA
HT5014_SIGMA
HT501640_SIGMA
HT501850_SIGMA
Hyperband
Hyperband (TN)
Ivalon
Karsan
Keton
ketone
ketones
LS-101266
LS-134
Lysoform
Melamine-Formaldehyde Resin
metaformaldehyde
Methaldehyde
Methan 21
methanal
Methyl aldehyde
methylene glycol
Methylene oxide
MolPort-001-785-627
Morbicid
nchem.467-comp1
nchembio.123-comp9
nchembio.146-comp5
nchembio.172-comp3
NCI-C02799
NSC 298885
NSC298885
Oilstop, Halowax
Oplossingen
Oplossingen [Dutch]
Oxomethane
Oxomethylene
Oxymethylene
P0018
P6148_SIAL
Paraform
PARAFORMALDEHYDE
Paraformaldehyde (JP15)
Paraformaldehyde (JP16)
Paraformaldehyde [JAN]
Paraformaldehyde [UN2213] [Flammable solid]
Paraformaldehyde [UN2213] [Flammable solid]
Paraformaldehyde, polymer
Paraformaldehydum
Paraformic aldehyde
Poly(oxymethylene)
Polyformaldehyde
Polymerised formaldehyde
Polyoxymethylene
Polyoxymethylene glycol
R-CO-R'
RC(=O)H
RCRA waste no. U122
RCRA waste number U122
RFPDT@
Superlysoform
UN 1198
UN 2209 (formalin)
UN1198
UN2209
UN2213
UNII-1HG84L3525
Veracur
WLN: VHH

Target

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Uniprot ID:G6PC_RAT
Synonyms:
G-6-Pase
G6Pase
Glucose-6-phosphatase
EC-Numbers:3.1.3.9
Organism:Rat
Rattus norvegicus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

200376
Inhibition by aldehydes as a possible further mechanism for glucose-6-phosphatase inactivation during CCl4-poisoning.. G Bertone; M U Dianzani (1977) Chemico-biological interactions display abstract
Diffusable aldehydes are known to be produced during lipoperoxidative deterioration of unsaturated fatty acids. Malealdehyde (MLA) and 4-hydroxy-2,3-trans-penten-1-al (4-HPE) inhibit rat liver glucose-6-phosphatase activity in vitro. With MLA inhibition is significant at 0.25 mM concentration. With 4-HPE inhibition takes place at 0.5 mM. 1 mM MLA inhibited by about 89%, 6 mM -HPE by about 67%. Maximal inhibition is present as early as 5 min after addition of both aldehydes. Preincubation of aldehydes with 2 mM cystein or glycine in the absence of microsomes almost completely prevents the inhibitory influence. Previous incubation of microsomes with 2 mM glutathione or 2 mM dithiothreitol or 2 mM cysteine affords a good protection towards the inhibitory action of the aldehydes; on the contrary, no protection is seen when microsomes are preincubated in the presence of either 2 mM glycine or asparagine. The total content of microsomes -SH groups is strongly decreased after incubation with 2mM malealdehyde. These results support the idea that the two aldehydes inhibit glucose-6-phosphatase mostly through interaction with protein -SH groups. The possibility that aldehydes derivated from the peroxidative decomposition of lipids may play a cooperative role in the inhibition of glucose-6-phosphatase occurring early after CCl4-poisoning is discussed.