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Drug-Target Interaction

Drug

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PubChem ID:667639
Structure:
Synonyms:
"trans-3,3′,4,5′-tetrahydroxystilbene"
(E)-4-[2-(3,5-Dihydroxyphenyl)ethenyl]1,2-benzenediol
(E)-4-[2-(3,5Dihydroxyphenyl)ethenyl]1,2-benzenediol
1,2-Benzenediol, 4-(2-(3,5-dihydroxyphenyl)ethenyl)-
1,2-Benzenediol, 4-(2-(3,5-dihydroxyphenyl)ethenyl)-, (E)-
1,2-Benzenediol, 4-[2-(3,5-dihydroxyphenyl)ethenyl]-, (E)-
1,2-Benzenediol, {4-[2-(3,} 5-dihydroxyphenyl)ethenyl\]-, (E)-
1,2-benzenediol, {4-[2-(3,} 5-dihydroxyphenyl)ethenyl]-, (e)-
10083-24-6
21100-92-5
3'-hydroxyresveratol
3,3',4',5-tetrahydroxystilbene
3,3',4'5-Tetrahydroxystilbene
3,3',4,5'-Stilbenetetrol
3,3',4,5'-tetrahydroxy stilbene
3,3',4,5'-Tetrahydroxy-trans-stilbene
3,3',4,5'-Tetrahydroxystilbene
3,5,3',4'-tetrahydroxy-stilbene
3,5,3',4'-tetrahydroxy-trans-stilbene
3,5,3',4'-Tetrahydroxystilbene
3-Hydroxyresveratol
4-(2-(3,5-Dihydroxyphenyl)vinyl)-1,2-benzenediol
4-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol
4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol
4-[(E)-2-(3,5-dihydroxyphenyl)vinyl]benzene-1,2-diol
4-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol
4339-71-3
5-[(E)-2-(3,4-Dihydroxyphenyl)vinyl]benzene-1,3-diol
AC-5281
AC1LDIIX
AC1Q7B1B
AIDS-160223
AIDS160223
AR-1F9519
astringinin
Astringinine
BIDD:ER0001
BiomolKI2_000031
BiomolKI_000023
BMK1-C11
BRD-K91509126-001-05-3
BSPBio_001120
C041525
C05901
C14H12O4
CCG-100627
CCRIS 9289
CHEBI:208981
CHEBI:28814
CHEMBL69863
CU-00000000400-1
DB08399
demethyl isorhapontigenin
E-Piceatannol
EU-0100915
F13BE9BB-B7D7-4D40-B31A-C15B953E033D
HMS1362H21
HMS1792H21
HMS1990H21
HMS2236B03
HMS3262H12
I14-6878
IDI1_002155
K00089
LMPK13090006
Lopac0_000915
LS-146872
LS-171757
MEGxp0_000245
MLS002153321
MolPort-001-740-425
NCGC00094226-01
NCGC00094226-02
NCGC00094226-03
NCGC00094226-04
NCGC00094226-05
NCGC00094226-06
NCGC00094226-07
nchembio.582-comp4
NSC 365798
NSC 622471
NSC-365798
NSC365798
NSC622471
P 0453
P0453_SIGMA
Piceatannol
piceatanol
PIT
RSVL-1
SMP2_000263
SMR001230734
ST50825907
trans-3,3′,4,5′-Tetrahydroxystilbene
trans-3,3',4,5'-Tetrahydroxystilbene
ZINC00014036

Target

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Uniprot ID:RAF1_MOUSE
Synonyms:
C-RAF
cRaf
RAF proto-oncogene serine/threonine-protein kinase
Raf-1
EC-Numbers:2.7.11.1
Organism:Mouse
Mus musculus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

15502405
Piceatannol prevents lipopolysaccharide (LPS)-induced nitric oxide (NO) production and nuclear factor (NF)-kappaB activation by inhibiting IkappaB kinase (IKK).. Shamima Islam; Ferdaus Hassan; Mya Mya Mu; Hiroyasu Ito; Naoki Koide; Isamu Mori; Tomoaki Yoshida; Takashi Yokochi (2004) Microbiology and immunology display abstract
The effect of piceatannol on lipopolysaccharide (LPS)-induced nitric oxide (NO) production was examined. Piceatannol significantly inhibited NO production in LPS-stimulated RAW 264.7 cells. The inhibition was due to the reduced expression of an inducible isoform of NO synthase (iNOS). The inhibitory effect of piceatannol was mediated by down-regulation of LPS-induced nuclear factor (NF)-kappaB activation, but not by its cytotoxic action. Piceatannol inhibited IkappaB kinase (IKK)-alpha and beta phosphorylation, and subsequently IkappaB-alpha phosphorylation in LPS-stimulated RAW 264.7 cells. On the other hand, piceatannol did not affect activation of mitogen-activated protein (MAP) kinases including extracellular signal regulated kinase 1/2 (Erk1/2), p38 and stress-activated protein kinase/c-Jun NH2-terminal kinase (SAPK/JNK). Piceatannol inhibited the phosphorylation of Akt and Raf-1 molecules, which regulated the activation of IKK-alpha and beta phosphorylation. The detailed mechanism of the inhibition of LPS-induced NO production by piceatannol is discussed.