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Drug-Target Interaction

Drug

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PubChem ID:667639
Structure:
Synonyms:
"trans-3,3′,4,5′-tetrahydroxystilbene"
(E)-4-[2-(3,5-Dihydroxyphenyl)ethenyl]1,2-benzenediol
(E)-4-[2-(3,5Dihydroxyphenyl)ethenyl]1,2-benzenediol
1,2-Benzenediol, 4-(2-(3,5-dihydroxyphenyl)ethenyl)-
1,2-Benzenediol, 4-(2-(3,5-dihydroxyphenyl)ethenyl)-, (E)-
1,2-Benzenediol, 4-[2-(3,5-dihydroxyphenyl)ethenyl]-, (E)-
1,2-Benzenediol, {4-[2-(3,} 5-dihydroxyphenyl)ethenyl\]-, (E)-
1,2-benzenediol, {4-[2-(3,} 5-dihydroxyphenyl)ethenyl]-, (e)-
10083-24-6
21100-92-5
3'-hydroxyresveratol
3,3',4',5-tetrahydroxystilbene
3,3',4'5-Tetrahydroxystilbene
3,3',4,5'-Stilbenetetrol
3,3',4,5'-tetrahydroxy stilbene
3,3',4,5'-Tetrahydroxy-trans-stilbene
3,3',4,5'-Tetrahydroxystilbene
3,5,3',4'-tetrahydroxy-stilbene
3,5,3',4'-tetrahydroxy-trans-stilbene
3,5,3',4'-Tetrahydroxystilbene
3-Hydroxyresveratol
4-(2-(3,5-Dihydroxyphenyl)vinyl)-1,2-benzenediol
4-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol
4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol
4-[(E)-2-(3,5-dihydroxyphenyl)vinyl]benzene-1,2-diol
4-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol
4339-71-3
5-[(E)-2-(3,4-Dihydroxyphenyl)vinyl]benzene-1,3-diol
AC-5281
AC1LDIIX
AC1Q7B1B
AIDS-160223
AIDS160223
AR-1F9519
astringinin
Astringinine
BIDD:ER0001
BiomolKI2_000031
BiomolKI_000023
BMK1-C11
BRD-K91509126-001-05-3
BSPBio_001120
C041525
C05901
C14H12O4
CCG-100627
CCRIS 9289
CHEBI:208981
CHEBI:28814
CHEMBL69863
CU-00000000400-1
DB08399
demethyl isorhapontigenin
E-Piceatannol
EU-0100915
F13BE9BB-B7D7-4D40-B31A-C15B953E033D
HMS1362H21
HMS1792H21
HMS1990H21
HMS2236B03
HMS3262H12
I14-6878
IDI1_002155
K00089
LMPK13090006
Lopac0_000915
LS-146872
LS-171757
MEGxp0_000245
MLS002153321
MolPort-001-740-425
NCGC00094226-01
NCGC00094226-02
NCGC00094226-03
NCGC00094226-04
NCGC00094226-05
NCGC00094226-06
NCGC00094226-07
nchembio.582-comp4
NSC 365798
NSC 622471
NSC-365798
NSC365798
NSC622471
P 0453
P0453_SIGMA
Piceatannol
piceatanol
PIT
RSVL-1
SMP2_000263
SMR001230734
ST50825907
trans-3,3′,4,5′-Tetrahydroxystilbene
trans-3,3',4,5'-Tetrahydroxystilbene
ZINC00014036

Target

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Uniprot ID:NOS3_HUMAN
Synonyms:
cNOS
Constitutive NOS
EC-NOS
Endothelial NOS
eNOS
Nitric oxide synthase, endothelial
NOS type III
NOSIII
EC-Numbers:1.14.13.39
Organism:Homo sapiens
Human
PDB IDs:1M9J 1M9K 1M9M 1M9Q 1M9R 3EAH 3NOS
Structure:
3NOS

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

17070777
Involvement of Syk kinase in TNF-induced nitric oxide production by airway epithelial cells.. Marina Ulanova; Marcelo Marcet-Palacios; Samira Muñoz; Samuel Asfaha; Moo-Kyung Kim; Alan D Schreiber; A Dean Befus (2006) Biochemical and biophysical research communications display abstract
We have recently found that Syk is widely expressed in lung epithelial cells (EC) and participates in beta1 integrin signaling. In this study, we assessed the role of Syk in regulation of NO production. Stimulation of human bronchial EC line HS-24 by TNF caused an increased expression of inducible nitric oxide synthase (iNOS). Inhibition of Syk using siRNA or piceatannol down-regulated the iNOS expression and reduced NO production. This effect occurred in EC simultaneously stimulated via beta1 integrins, suggesting that TNF and beta1 integrins provide co-stimulatory signals. Inhibition of Syk down-regulated TNF-induced p38 and p44/42 MAPK phosphorylation and nuclear translocation of p65 NF-kappaB. Thus, TNF-induced activation of pro-inflammatory signaling in EC leading to enhanced expression of iNOS and NO production was dependent on Syk. Syk-mediated signaling regulates NO production at least partly via activating the MAPK cascade. Understanding the role of Syk in airway EC may help in developing new therapeutic tools for inflammatory lung disorders.