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Drug-Target Interaction

Drug

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PubChem ID:657262
Structure:
Synonyms:
(E)-N',2-diphenyldiazenecarbothiohydrazide
(Phenylazo)thioformic acid 2-phenylhydrazide
(Phenylazo)thioformic acid, 2-phenylhydrazide
1,5-Diphenyl-3-mercaptoformazan
1,5-Diphenyl-3-thiocarbazone
1-anilino-3-phenyliminothiourea
194832_SIAL
3-Formazanthiol, 1,5-diphenyl-
30827-05-5
33154_FLUKA
33154_RIEDEL
43820_FLUKA
43820_SIAL
555-88-4
60-10-6
AC1LCW9O
AI3-52366
AIDS-027533
AIDS027533
AKOS003193919
Carbazone, diphenylthio-
CPD-11586
D0949
D5130_SIAL
Diazenecarbohydrazonothioic acid, N,2-diphenyl-
Diazenecarbothioic acid, 2-phenyl-, 2-phenylhydrazide
Diazenecarbothioic acid, phenyl-, 2-phenylhydrazide
Diphenylthiocarbazone
Dithizon
Dithizone
Ditizon
EINECS 200-454-1
Formic acid, (phenylazo)thio-, 2-phenylhydrazide
HMS2235C06
I09-0100
LS-69698
MLS000028397
MolPort-009-756-444
NCGC00018169-01
NCGC00018169-02
NCGC00018169-03
NCIOpen2_006427
NSC 215189
NSC215189
NSC4275
NSC99124
SBB008744
Semicarbazide, 1-phenyl-4-(phenylimino)-3-thio-
SMR000058361
ST50825972
Thioformic acid, phenylazo-, phenylhydrazide
Usaf ek-3092
WLN: RNUNYUS&MMR
ZINC17950622

Target

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Uniprot ID:ICE_DROME
Synonyms:
Caspase
drICE
EC-Numbers:3.4.22.-
Organism:Drosophila melanogaster
Fruit fly
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References:

12008084
A metal chelator, diphenylthiocarbazone, induces apoptosis in acute promyelocytic leukemia (APL) cells mediated by a caspase-dependent pathway without a modulation of retinoic acid signaling pathways.. Chiharu Kawamura; Masahiro Kizaki; Yumi Fukuchi; Yasuo Ikeda (2002) Leukemia research display abstract
A metal chelator, diphenylthiocarbazone (dithizone), has been reported to induce differentiation and apoptosis of the human myeloid leukemia cell line HL-60, however, very little is known about the mechanism of dithizone-induced apoptosis. Here, we report for the first time that dithizone can induce inhibition of cellular growth of retinoic acid (RA)-sensitive NB4 and RA-resistant UF-1 APL cells via induction of apoptosis but not differentiation. Treatment of NB4 cells with dithizone markedly-induced apoptosis, which was associated with the loss of mitochondrial transmembrane potentials (Delta Psi(m)) and activation of caspase-3 and -9. Further investigation of the RA-resistant UF-1 APL cells showed that dithizone-induced apoptosis to a lesser extent. However, neither dithizone alone nor in combination with all-trans RA induced the expression of myeloid differentiation antigen CD11b. Concomitantly, the degradation of PML/RARalpha fusion protein was not observed after treatment with dithizone alone, and the degradation was not enhanced by the combination of dithizone and all-trans RA. We conclude that dithizone, a metal chelator, induced apoptosis without differentiation in APL cells in association with Delta Psi(m) collapse and caspase-3 and -9 activation.