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Drug-Target Interaction

Drug

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PubChem ID:65063
Structure:
Synonyms:
1-{(4S,2R,5R)-4-Hydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl}-1,3-dihydropyrimidine-2,4-dione
135556-16-0
1bp0
1jmf
1jmg
1jmi
1njb
1njd
1tsv
1tsy
2'-Deoxy-5'-uridylic acid
2'-Deoxyuridine 5'-monophosphate
2'-Deoxyuridine 5'-phosphate
2'-Deoxyuridylate
2'-Deoxyuridylic acid
2,4(1H,3H)-pyrimidinedione, 1-(2-deoxy-5-O-phosphono-beta-D-erythro-pentofuranosyl)-
4-24-00-01200 (Beilstein Handbook Reference)
42155-08-8
42155-08-8 (di-hydrochloride salt)
5'-Uridylic acid, 2'-deoxy-
87578-10-7
964-26-1
AC1L22ID
AIDS-159513
AIDS159513
BRN 0042143
C00365
CHEBI:17622
CHEMBL211312
DB03800
Deoxy-UMP
Deoxyuridine 5'-monophosphate
Deoxyuridine 5'-phosphate
Deoxyuridine monophosphate
deoxyuridylate
Deoxyuridylic acid
DU
dUMP
EINECS 213-518-9
LS-160817
UMP
Uridine, 2'-deoxy-, 5'-(dihydrogen phosphate)
Uridine, 2'-deoxy-, 5'-phosphate
[(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl
[(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl dihydrogen phosphate

Target

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Uniprot ID:TYSY_LACCA
Synonyms:
Thymidylate synthase
TS
TSase
EC-Numbers:2.1.1.45
Organism:Lactobacillus casei
PDB IDs:1BO7 1BO8 1BP0 1BP6 1BPJ 1JMF 1JMG 1JMH 1JMI 1LCA 1LCB 1LCE 1NJA 1NJB 1NJC 1NJD 1NJE 1TDA 1TDB 1TDC 1THY 1TSL 1TSM 1TSV 1TSW 1TSX 1TSY 1TSZ 1TVU 1TVV 1TVW 1VZA 1VZB 1VZC 1VZD 1VZE 2G86 2G89 2G8A 2G8D 2TDD 2TDM 3BNZ 3BYX 3BZ0 3C06 3C0A 4TMS
Structure:
4TMS

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References: