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Drug-Target Interaction

Drug

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PubChem ID:6436247
Structure:
Synonyms:
70563-58-5
AC1O5LAW
AIDS-071761
AIDS071761
Antibiotic Tan 420F
CID6436247
Geldanamycin, 17-demethoxy-15-methoxy-11-O-methyl-, (15R)-
Herbimycin
Herbimycin A
LS-71126
NSC 305978
NSC305978
[(2R,3S,5S,6R,7S,8E,10S,11S,12E,14E)-2,5,6,11-tetramethoxy-3,7,9,15-tetram

Target

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Uniprot ID:Q9JHC2_RAT
Synonyms:
Matrix metalloproteinase 2
MMP-2
EC-Numbers:-
Organism:Rat
Rattus norvegicus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

15221343
Effects of magnesium on matrix metalloproteinase-2 production in cultured rat cardiac fibroblasts.. Hong Yue; Hiroyasu Uzui; Jong-Dae Lee; Hiromasa Shimizu; Takanori Ueda (2004) Basic research in cardiology display abstract
The precise correlation between magnesium and cardiac disease remains to be established. Matrix metalloproteinases (MMPs) are important in cardiac disease such as heart failure. Cardiac fibroblasts are the most abundant cell type in the heart and play an important role in the regulation of collagen degradation by MMPs. To assess the association between magnesium and MMPs, we examined the effects of different extracellular magnesium concentrations (0-3.0 mmol/L) on MMP-2 production in cultured rat cardiac fibroblasts. Using gelatin zymography and western blotting, we found that magnesium reduced MMP-2 production dose-dependently, and this effect was inhibited by the tyrosine kinase inhibitors, genistein or herbimycin A. The results of this study indicated that the beneficial effect of magnesium supplementation on the cardiac disease may be due, at least in part, to the inhibitory effect of magnesium on production of MMPs in cardiac fibroblasts, which appears to be mediated by a protein tyrosine phosphorylation related signal transduction pathway.