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Drug-Target Interaction

Drug

show drug details
PubChem ID:62959
Structure:
Synonyms:
(1alpha,5alpha,6alpha)-7-(6-Amino-3-azabicyclo[3.1.0]hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-7-(6-amino-3-azabicyclo(3.1.0)hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-, (1-alpha,5-alpha,6-alpha)-
1,8-Naphthyridine-3-carboxylic acid, 7-(6-amino-3-azabicyclo[3.1.0]hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, (1alpha,5alpha,6alpha)-
146836-84-2
146836-84-2 (MESYLATE DELETED)
147059-72-1
147059-72-1 (FREE BASE)
147059-75-4 (MESYLATE)
7-((1R,5S)-6-Amino-3-aza-bicyclo[3.1.0]hex-3-yl)-1-(2,4-difluoro-phenyl)-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid
7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-
7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
AIDS-010848
AIDS-106741
AIDS010848
AIDS106741
C07664
C20H15F3N4O3
CP-99,219
CP-99219-27
CP99219
DB00685
Fluorinated quinolone
LS-95890
Trovafloxacin
Trovafloxacin (INN)
Trovafloxacin mesylate
Trovafloxacin [INN]
Trovan
Trovan (oral)
TVFX
ATC-Codes:
Side-Effects:
Side-EffectFrequency
dizziness0.065000005
nausea0.056666672
headache0.03
lightheadedness0.023333332
vomiting0.020000001
diarrhea0.02
rash0.015
vaginitis0.015
pruritus0.014999998
abdominal pain0.0050
liver failure0.0010
hepatic necrosis0.0010
stevens - johnson syndrome0.0010
pancytopenia0.0010
agranulocytosis0.0010
anaphylaxis0.0010
aplastic anemia0.0010
eosinophilia0.0010
hepatitis0.0010
pancreatitis0.0010
pseudomembranous colitis0
tendinitis0
dysphagia0
palpitations0
change in bowel habits0
peripheral edema0
thrombophlebitis0
anorexia0
migraine0
muscle cramps0
thrombocythemia0
somnolence0
asthma0
angioedema0
ischemia0
convulsions0
agitation0
bronchospasm0
dyskinesia0
acute renal failure0
fungal dermatitis0
stomatitis0
nervousness0
enteritis0
conjunctivitis0
urinary frequency0
tachycardia0
dermatitis0
dyspepsia0
photophobia0
rhinitis0
anxiety0
myalgia0
arthralgia0
upper respiratory tract infection0
dysphonia0
menstrual disorder0
increased sweating0
halitosis0
hypotension0
melena0
thinking abnormal0
depersonalization0
emotional lability0
sepsis0
insomnia0
amnesia0
tremor0
interstitial nephritis0
epistaxis0
thrombocytopenia0
hiccup0
hemorrhage0
hallucinations0
chest pain0
hypoxia0
dyspnea0
abnormal vision0
angina pectoris0
euphoria0
constipation0
gastritis0
jaundice0
prostatitis0
gastroenteritis0
paresthesia0
colitis0
visual field defect0
pain0
decreased libido0
tooth disorder0
syncope0
photosensitivity0
bradycardia0
flushing0
anemia0
dry mouth0
back pain0
diplopia0
hyperacusis0
bilirubinemia0
fever0
impotence0
confusion0
muscle weakness0
hypertension0
pruritus ani0
bone pain0
eye pain0
urticaria0
leukopenia0
stridor0
dysuria0
concentration impaired0
encephalopathy0
moniliasis0
paralysis0
hemoptysis0
abnormal gait0
arthrosis0
urinary incontinence0
malaise0
allergic reaction0
weight loss0
weight gain0
tinnitus0
vertigo0
gingivitis0
sinusitis0
seborrhea0
chills0
cough0
flatulence0
skin ulcer0
hyperglycemia0
edema0
nightmares0
ataxia0
fatigue0
asthenia0
eructation0

Target

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Uniprot ID:GYRB_ECOLI
Synonyms:
DNA gyrase subunit B
EC-Numbers:5.99.1.3
Organism:Escherichia coli
strain K12
PDB IDs:1AJ6 1EI1 1KZN
Structure:
1KZN

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: