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Drug-Target Interaction

Drug

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PubChem ID:60937
Structure:
Synonyms:
(((p-Chlorophenyl)thio)methylene)diphosphonic acid
149845-07-8
149845-07-8 (disodium)
89987-06-4
96538-83-9
AC1L1U70
AC1Q3OOE
Acide tiludronique
Acide tiludronique [INN-French]
Acido tiludronico
Acido tiludronico [INN-Spanish]
Acidum tiludronicum
Acidum tiludronicum [INN-Latin]
acpmd
BIDD:GT0814
C08141
CHEMBL1350
D08599
DB01133
LS-183988
SR 41319
SR-41319
Tiludronate
Tiludronate disodium
Tiludronic acid
Tiludronic acid (INN)
Tiludronic Acid Disodium Salt
Tiludronic acid [BAN:INN]
Tiludronic acid [INN:BAN]
UNII-6PNS59HP4Y
[(4-chlorophenyl)sulfanyl-phosphonomethyl]phosphonic acid
ATC-Codes:
Side-Effects:
Side-EffectFrequency
headache0
nausea0
tooth disorder0
hyperparathyroidism0
pain0
peripheral edema0
vomiting0
bronchitis0
diarrhea0
vertigo0
chest pain0
anxiety0
syncope0
flushing0
infection0
somnolence0
paresthesia0
upper respiratory tract infection0
anorexia0
arthralgia0
cataract0
arthrosis0
conjunctivitis0
dyspepsia0
insomnia0
increased sweating0
flatulence0
cough0
vitamin d deficiency0
sinusitis0
rhinitis0
constipation0
back pain0
pathological fracture0
rash0
hypertension0
nervousness0
urinary tract infection0
glaucoma0
fatigue0
pharyngitis0
dry mouth0
abdominal pain0
asthenia0
influenza0
pruritus0
dizziness0
edema0
gastritis0

Target

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Uniprot ID:PTN1_HUMAN
Synonyms:
Protein-tyrosine phosphatase 1B
PTP-1B
Tyrosine-protein phosphatase non-receptor type 1
EC-Numbers:3.1.3.48
Organism:Homo sapiens
Human
PDB IDs:1A5Y 1AAX 1BZC 1BZH 1BZJ 1C83 1C84 1C85 1C86 1C87 1C88 1ECV 1EEN 1EEO 1G1F 1G1G 1G1H 1G7F 1G7G 1GFY 1I57 1JF7 1KAK 1KAV 1L8G 1LQF 1NL9 1NNY 1NO6 1NWE 1NWL 1NZ7 1OEM 1OEO 1OES 1OET 1OEU 1OEV 1ONY 1ONZ 1PA1 1PH0 1PTT 1PTU 1PTV 1PTY 1PXH 1PYN 1Q1M 1Q6J 1Q6M 1Q6N 1Q6P 1Q6S 1Q6T 1QXK 1SUG 1T48 1T49 1T4J 1WAX 1XBO 2AZR 2B07 2B4S 2BGD 2BGE 2CM2 2CM3 2CM7 2CM8 2CMA 2CMB 2CMC 2CNE 2CNF 2CNG 2CNH 2CNI 2F6F 2F6T 2F6V 2F6W 2F6Y 2F6Z 2F70 2F71 2FJM 2FJN 2H4G 2H4K 2HB1 2HNP 2HNQ 2NT7 2NTA 2QBP 2QBQ 2QBR 2QBS 2VEU 2VEV 2VEW 2VEX 2VEY 2ZMM 2ZN7 3CWE 3D9C 3EAX 3EB1 3EU0
Structure:
3EU0

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: