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Drug-Target Interaction

Drug

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PubChem ID:6083
Structure:
Synonyms:
(S)-1-C-(7-Amino-1H-pyrazolo(4,3-d)pyrimidin-3-yl)-1,4-anhydro-D-ribitol, 5-(dihydrogen phosphate)
103106-41-8
103106-44-1
104714-92-3
104714-93-4
13270-66-1
162756-82-3
1H-Pyrazolo(4,3-d)pyrimidine, 7-amino-3-beta-D-ribofuranosyl-, 5'-(dihydrogen phosphate)-, hydrate
1pyg
1ua4
1z6s
24937-83-5
2gsu
34051-12-2
4-26-00-03615 (Beilstein Handbook Reference)
47286-65-7
47287-97-8
5'-Adenosine monophosphate
5'-Adenylic acid
5'-Adenylic acid, 5'-thio-
5'-Adenylic acid, 8-amino-
5'-Adenylic acid, homopolymer
5'-AMP
5'-Deoxy-5'-thioadenosine 5'-monophosphate
5'-O-phosphonoadenosine
5'-Thio-5'-adenylic acid
53624-78-5
55036-25-4
61-19-8
67583-85-1
67583-86-2
7-Amino-3-beta-D-ribofuranosyl-1H-pyrazolo(4,3-d)pyrimidine 5'-(dihydrogen
7-Amino-3-beta-D-ribofuranosyl-1H-pyrazolo(4,3-d)pyrimidine 5'-(dihydrogen phosphate) hydrate
75433-15-7
75433-16-8
75433-18-0
75433-21-5
75433-22-6
75433-24-8
75433-26-0
75433-27-1
7gpb
8-Aminoadenosine 5'-monophosphate
8gpb
9H-Purin-6-amine, 9-(5-O-phosphono-.beta.-D-ribofuranosyl)-
9H-purin-6-amine, 9-(5-O-phosphono-beta-D-ribofuranosyl)-
a-5mp
A5MP
Adenine polynucleotides
Adenosine 5'-(dihydrogen phosphate)
Adenosine 5'-monophosphate
Adenosine 5'-monophosphoric acid
Adenosine 5'-phosphate
Adenosine 5'-phosphoric acid
Adenosine monophosphate
Adenosine phosphate
Adenosine phosphate (USAN/INN)
Adenosine phosphate [USAN:BAN:INN]
Adenosine phosphate [USAN:INN:BAN]
Adenosine, mono(dihydrogen phosphate) (ester)
Adenosine-5'-monophosphate
Adenosine-5'-monophosphoric acid
adenosine-5'-phosphate
adenosine-5'P
Adenosine-5-monophosphoric acid
Adenosine-5-phosphate
adenosine-monophosphate
adenosine-phosphate
Adenosini phosphas
Adenosini phosphas [INN-Latin]
Adenovite
Adenyl
Adenyl (TN)
Adenylate
Adenylic acid
Adenylic acid (VAN)
Ado5'P
AIDS-021665
AIDS021665
AMP
AMP (nucleotide)
AMP (VAN)
ANP
ASMP
ATS
BPBio1_000497
BRN 0054612
BSPBio_000451
C00020
Cardiomone
CHEBI:16027
D02769
DB00131
EINECS 200-500-0
Ergadenylic acid
Formycin 5'-monophosphate hydrate
Formycin 5'-phosphate
Formycin 5'-phosphate hydrate
Formycin A 5'-monophosphate hydrate
Fosfato de adenosina
Fosfato de adenosina [INN-Spanish]
GAMMA-ARSONO-BETA, GAMMA-METHYLENEADENOSINE-5'-DIPHOSPHATE
HSDB 3281
LS-129209
LS-15192
Lycedan
Monophosphadenine
Muscle adenylic acid
Muskeladenosin-phosphorsaeure
Muskeladenylsaeure
My-B-Den
Myoston
NCGC00163319-01
NCGC00163319-02
NSC 20264
NSC-20264
NSC20264
P5P
PAdo
Phosaden
Phosphaden
Phosphate d'adenosine
Phosphate d'adenosine [INN-French]
Phosphentaside
POLY A
Polyadenylic acid
Polyadenylic acids
Prestwick0_000356
Prestwick1_000356
Prestwick2_000356
Prestwick3_000356
SBB001403
SPBio_002372
Vitamin B8
[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate

Target

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Uniprot ID:KCRU_HUMAN
Synonyms:
Acidic-type mitochondrial creatine kinase
Creatine kinase U-type, mitochondrial
Mia-CK
U-MtCK
Ubiquitous mitochondrial creatine kinase
EC-Numbers:2.7.3.2
Organism:Homo sapiens
Human
PDB IDs:1QK1
Structure:
1QK1

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

204431
Adenylate kinase inhibition by adenosine 5'-monophosphate and fluoride in the determination of creatine kinase activity.. F Meiattini; G Giannini; P Tarli (1978) Clinical chemistry display abstract
The current methods for the determination of creatine kinase (EC 2.7.3.2) activity are derived from Oliver's method, in which AMP is used to decrease interference by adenylate kinase (EC 2.7.4.3). Recently, Szasz et al. and Rosano et al. described methods in which diadenosine pentaphosphate and fluoride, respectively, are used to reduce this interference. However, diadenosine pentaphosphate does not sufficiently inhibit such activity of hepatic origin, while fluoride alone can only inhibit it at concentrations at which the fluoride tends to precipitate as MgF2. Finally, Szasz et al., the Committee on Enzymes of the Scandinavian Society for Clinical Chemistry and Clinical Physiology, and the German Society for Clinical Chemistry have proposed methods in which both AMP and diadenosine pentaphosphate are used to inhibit adenylate kinase. We have found that by using low concentrations of AMP and fluoride together, we can greatly diminish this interference without significant loss of creatine kinase activity and with no precipitation of MgF2.