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Drug-Target Interaction

Drug

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PubChem ID:60654
Structure:
Synonyms:
115956-12-2
1H-Indole-3-carboxylic acid,
1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2alpha,6alpha,8alpha,9abeta)-
C19H20N2O3
DB00757
Dolasetron
Dolasetron [INN:BAN]
Dolasetronum [INN-Latin]
LS-172300
ATC-Codes:
Side-Effects:
Side-EffectFrequency
headache0.13669339
diarrhea0.06298523
hypotension0.05649626
bradycardia0.045451898
fatigue0.0374038
fever0.035611954
pruritus0.032040115
dizziness0.029990667
abdominal pain0.026431654
dyspepsia0.025968933
pain0.025829602
drowsiness0.025512176
hypertension0.024629056
urinary retention0.021260176
tachycardia0.019836811
chills0.01735694
myocardial infarction0.0010
cardiac arrest0.0010
ventricular fibrillation0.0010
arrhythmias0.0010
ventricular tachycardia0.0010
thrombocytopenia0
pancreatitis0
paresthesia0
syncope0
phlebitis0
stomatitis0
sneezing0
pneumonia0
shock0
purpura0
polyuria0
thrombophlebitis0
tinnitus0
increased sweating0
ecg abnormal0
sepsis0
myalgia0
malaise0
sgot increased0
alkaline phosphatase increased0
myocardial ischemia0
peripheral edema0
photophobia0
agitation0
dry mouth0
abnormal vision0
vertigo0
urticaria0
loss of consciousness0
tremor0
sleep disorder0
palpitations0
abdominal distention0
depersonalization0
dehydration0
cough0
constipation0
confusion0
chest pain0
bundle branch block0
bronchospasm0
av block0
atrial flutter0
ataxia0
arthralgia0
anxiety0
anorexia0
angioedema0
anemia0
dyspnea0
dysuria0
liver disease0
acute renal failure0
ischemia0
influenza0
postural hypotension0
hypersensitivity0
bilirubinemia0
hiccup0
hematuria0
hematoma0
heart block0
flushing0
flatulence0
rash0
eructation0
epistaxis0
edema0
anaphylaxis0

Target

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Uniprot ID:CP2C9_HUMAN
Synonyms:
(R)-limonene 6-monooxygenase
(S)-limonene 6-monooxygenase
(S)-limonene 7-monooxygenase
CYPIIC9
Cytochrome P450 2C9
P-450MP
P450 MP-4/MP-8
P450 PB-1
S-mephenytoin 4-hydroxylase
EC-Numbers:1.14.13.48
1.14.13.49
1.14.13.80
Organism:Homo sapiens
Human
PDB IDs:1OG2 1OG5 1R9O
Structure:
1R9O

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: