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Drug-Target Interaction

Drug

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PubChem ID:6049
Structure:
Synonyms:
"edta, 500 mm solution, ph 8.0, ultrol® grade"
(ethane-1,2-diyldinitrilo)tetraacetate
(ethane-1,2-diyldinitrilo)tetraacetic acid
(Ethylenedinitrilo)tetraacetic acid
(Ethylenedinitrilo)tetraacetic acid, disodium salt
(ethylenedinitrilo)tetraacetic acid, ion(4-)
03610_FLUKA
03620_FLUKA
03690_FLUKA
10058-42-1
10058-42-1 (iron(3+) salt)
13440-78-3
139-33-3
139-33-3 (di-hydrochloride salt)
139-33-3 (DISODIUM SALT)
150-38-9
150-38-9 (TRISODIUM SALT)
161122-33-4
17421-79-3
17421-79-3 (mono-hydrochloride salt)
2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate
2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetic acid
2-({2-[bis(carboxymethyl)amino]ethyl}(carboxymethyl)amino)acetic acid
2-[2-(bis(carboxymethyl)amino)ethyl-(carboxymethyl)amino]acetic acid
2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid
2001-94-7
2001-94-7 (di-potassium salt)
20539-27-9
24669-13-4
24669-13-4 (chromium salt)
26627-46-3
3,6-Diazaoctanedioic acid, 3,6-bis(carboxymethyl)-
30485-87-1
30485-88-2
30485-90-6
32757-10-1
37C3C5E7-D921-445F-82D6-FEBF1AE5AEF5
4-04-00-02449 (Beilstein Handbook Reference)
431788_ALDRICH
4H-imidazol-4-one, 2-amino-1,5-dihydro-1-methyl-
53404-51-6
53404-51-6 (mono-potassium salt)
60-00-4
6381-92-6
6381-92-6 (di-hydrochloride salt, di-hydrate)
6381-92-6 (DISODIUM SALT)
7379-27-3
7379-27-3 (potassium salt)
7379-28-4
7379-28-4 (hydrochloride salt)
76353-66-7
76353-66-7 (calcium,hydrochloride salt)
94108-75-5
AC-10615
AC1L1LOX
Acetic acid,
Acetic acid, (ethylenedinitrilo)tetra-
Acetic acid, (ethylenedinitrilo)tetra-, disodium salt
Acetic acid, 2,2',2'',2'''-(1,2-ethanediyldinitrilo)tetrakis-
Acide edetique
Acide edetique [INN-French]
Acide ethylenediaminetetracetique
Acide ethylenediaminetetracetique [French]
Acido edetico
Acido edetico [INN-Spanish]
Acidum edeticum
Acidum edeticum [INN-Latin]
Acroma DH 700
AI3-17181
AIDS-002613
AIDS002613
AKOS001574475
BIDD:ER0565
BRN 1716295
BSPBio_001964
C00284
C10H16N2O8
CaEDTA
Calcium Disodium Edetate
Calcium Disodium Edetate (JAN)
Calcium Disodium Versenate
Calcium disodium versenate (TN)
Calcium Tetacine
Caswell No. 438
CBC 50152966
CCRIS 946
Celon A
Celon ATH
CHEBI:165917
CHEBI:42191
Cheelox
Cheelox BF acid
Cheladrate
Chelaplex III
Chelating agents
Chelaton 3
Chelaton III
Chelest 3A
CHEMBL858
Chemcolox 340
Chromium EDTA
Clewat TAA
Complexon II
Complexon III
Copper EDTA
Coprin
D'E.d.t.a. Disodique
D00052
DB00974
Dicobalt EDTA
Diso-Tate
Disodium (ethylenedinitrilo)tetraacetate
Disodium (ethylenedinitrilo)tetraacetic acid
Disodium Calcitetracemate
Disodium diacid ethylenediaminetetraacetate
Disodium dihydrogen ethylenediaminetetraacetate
Disodium dihydrogen(ethylenedinitrilo)tetraacetate
Disodium edetate
Disodium EDTA
Disodium Ethylene Dinitrilotetraacetate
Disodium ethylenediamine-N,N,N',N'-tetraacetate
Disodium ethylenediaminetetraacetate
Disodium ethylenediaminetetraacetic acid
Disodium salt of EDTA
Disodium sequestrene
Disodium tetracemate
Disodium versenate
Disodium versene
Dissolvine E
Distannous EDTA
DivK1c_000777
DR-16133
E0084
E6758_SIGMA
E8008_SIGMA
E9884_SIAL
Edathamil
Edathamil calcium disodium
Edathamil disodium
Edetate
Edetate Calcium
Edetate calcium disodium (USP)
Edetate Disodium
Edetates
Edetic acid
Edetic acid (NF/INN)
Edetic acid disodium salt
Edetic acid [BAN:INN]
Edetic acid [INN:BAN]
Edetic Acid, Disodium, Magnesium Salt
EDS_SIAL
EDT
EDTA
EDTA (chelating agent)
EDTA acid
Edta disodium
EDTA disodium salt
EDTA solution
EDTA, 500 mM Solution, pH 8.0, ULTROL®
EDTA, 500 mM Solution, pH 8.0, ULTROL® Grade
EDTA, ion(4-)
Edtacal
ED_SIAL
EINECS 200-449-4
Endrate
Endrate disodium
EPA Pesticide Chemical Code 039101
Ethylene Dinitrilotetraacetate
Ethylenebis(iminodiacetic acid)
Ethylenebisiminodiacetic acid
ETHYLENEDIAMINE TETRAACETIC ACID
Ethylenediamine-N,N,N',N'-tetraacetic acid
Ethylenediaminetetraacetate
Ethylenediaminetetraacetate, disodium salt
Ethylenediaminetetraacetic acid
Ethylenediaminetetraacetic acid disodium salt
Ethylenediaminetetraacetic acid solution
Ethylenediaminetetraacetic acid, 2Na (EDTA)
ETHYLENEDIAMINETETRAACETIC ACID, ACS
Ethylenediaminetetraacetic acid, disodium salt
Ethylenedinitrilotetraacetic acid
F 1 (Complexon)
FT-0083197
Gallium EDTA
Gluma cleanser
Glycine, N,N'-1, {2-ethanediylbis[N-(carboxymethyl)-,} disodium salt
Glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl))-
Glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)-
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-
Grade
H4edta
Hamp-ene acid
Havidote
HSDB 809
I04-0860
ICRF 185
IDI1_000777
KBio1_000777
KBio2_001498
KBio2_004066
KBio2_006634
KBio3_001184
KBioGR_001161
KBioSS_001498
Kiresuto B
Komplexon II
Kyselina ethylendiamintetraoctova
Kyselina ethylendiamintetraoctova [Czech]
LS-12098
Magnesium Disodium EDTA
Metal chelating agent
Metaquest A
Metaquest B
MLS001249457
N,N'-1,2-Ethane diylbis-(N-(carboxymethyl)glycine)
N,N'-1,2-Ethanediylbis(N-(carboxymethyl)glycine)
NCGC00159485-02
NCGC00159485-03
NCGC00159485-04
Nervanaid B acid
NINDS_000777
NSC2760
NSC2760 (DISODIUM SALT)
Nullapon B acid
Nullapon BF acid
Perma kleer 50 acid
Perma kleer 50 crystals disodium salt
Perma Kleer Di Crystals
Potassium EDTA
Quastal Special
Questex 4H
SBB008807
Selekton B2
SEQ 100
Sequestrene AA
Sequestrene Na2
Sequestrene sodium 2
Sequestric acid
Sequestrol
SMR000058776
Sodium ethylenediaminetetraacetate
Sodium versenate
SPBio_000005
Spectrum2_000003
Spectrum3_000412
Spectrum4_000531
Spectrum5_000955
Spectrum_001018
ST072179
Stannous EDTA
STK386291
Techrun DO
Tetracemate
Tetrine acid
Titriplex
Titriplex II
Titriplex III
Trilon B
Trilon BD
Trilon BS
Trilon BW
Triplex III
UNII-9G34HU7RV0
Universne acid
Versenate
Versene
Versene acid
Versene acid (TN)
Versene NA
Versene Na2
Vinkeil 100
Warkeelate acid
YD 30
ZC00001
Zonon AO
{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID
ATC-Codes:
Side-Effects:
Side-EffectFrequency
anemia0
pain0
paresthesia0
proteinuria0
sneezing0
thrombophlebitis0
tremor0
vomiting0
chills0
polydipsia0
cheilosis0
malaise0
myalgia0
numbness0
nephrosis0
nausea0
anorexia0
arthralgia0
exfoliative dermatitis0
diarrhea0
rash0
fatigue0
fever0
glycosuria0
headache0
hematuria0
hypotension0
nasal congestion0
hyperuricemia0

Target

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Uniprot ID:AT1A3_MOUSE
Synonyms:
Na(+)/K(+) ATPase alpha(III) subunit
Na(+)/K(+) ATPase alpha-3 subunit
Sodium pump subunit alpha-3
Sodium/potassium-transporting ATPase subunit alpha-3
EC-Numbers:3.6.3.9
Organism:Mouse
Mus musculus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

139465
Inhibition of renal adenosine triphosphatase by cadmium.. B R Nechay; J P Sauners (1977) The Journal of pharmacology and experimental therapeutics display abstract
The effects of CdCl2 on adenosine triphosphatase (ATPase) were studied microsomal fractions or tissue homogenates of outer cortex, inner cortex and outer medulla of dog kidney. Cd was found to be an inhibitor of Na+ +K+ Atpase with 150 value of 2.1 to 3.2 X 10(-4) M regardless of type or source of the enzyme preparation tested. Mg++ ATPase was about 10-fold less sensitive to inhibition by Cd than Na+ +K+ ATPase. The inhibition of microsomal NA+ +K+ ATPase from outer medulla was characterized by irreversible kinetics. The inhibitory effect was not altered by varying Na+ or K+ concentrations, but was decreased by disodium ethylenediaminetetracetic acid (EDTA). EDTA was more effective in preventing than in reversing the inhibition. Na+ +K+ ATPase from kidneys of several other mammalian species showed a similar sensitivity to Cd.