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Drug-Target Interaction

Drug

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PubChem ID:60464
Structure:
Synonyms:
110871-86-8
111542-93-9
3-Quinolinecarboxylic acid, 1,4-dihydro-5-amino-1-cyclopropyl-6,8-difluoro-7-(3,5-dimethyl-1-piperazinyl)-4-oxo-, cis-
3-Quinolinecarboxylic acid, 5-amino-1-cyclopropyl-7-((3R,5S)-3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-, rel-
3-Quinolinecarboxylic acid, 5-amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-, cis-
33967_FLUKA
33967_RIEDEL
5-Amino-1-cyclohexyl-7-(cis-3,5-dimethylpiperazino)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
5-Amino-1-cyclopropyl-7-(cis-3,5-dimethyl)-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid & RU 40555
5-Amino-1-cyclopropyl-7-(cis-3,5-dimethyl-1-piperazinyl)- 6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
5-Amino-1-cyclopropyl-7-(cis-3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
5-amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-
5-amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
5-amino-1-cyclopropyl-7-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxoquinoline-3-carboxylic acid
56968_FLUKA
56968_SIGMA
AIDS-007774
AIDS-008531
AIDS-072387
AIDS007774
AIDS008531
AIDS072387
AT 4140
AT-4140
BB_SC-1127
BRN 3658018
C07662
C19H22F2N4O3
CHEBI:9212
CI 978
CI-978
cis-5-Amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
CP 103826
CP-103826
CPD000466312
D00590
DB01208
DRG-0143
Esparfloxacino
Esparfloxacino [INN-Spanish]
Liposome-encapsulated sparfloxacin
LS-141521
MLS000759417
NCGC00166294-01
PD 131501
PD-131501
PD131501
RP-64206
SAM001246566
SMR000466312
Spara
Sparfloxacin
Sparfloxacin & RU 40555
Sparfloxacin (JAN/USAN/INN)
Sparfloxacin [USAN:BAN:INN:JAN]
sparfloxacin, cis-isomer
Sparfloxacine
Sparfloxacine [INN-French]
Sparfloxacinum
Sparfloxacinum [INN-Latin]
SPFX
Zagam
Zagam (TN)
ATC-Codes:

Target

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Uniprot ID:Q7VFP2_HELHP
Synonyms:
DNA gyrase
EC-Numbers:5.99.1.3
Organism:Helicobacter hepaticus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

12821490
Inhibitory activities of quinolones against DNA gyrase of Chlamydia pneumoniae.. Satoshi Ameyama; Yuko Shinmura; Masahiro Takahata (2003) Antimicrobial agents and chemotherapy display abstract
The gyrA and gyrB genes of Chlamydia pneumoniae TW-183 were cloned, and their proteins were purified by use of a fusion system with a maltose-binding protein. The 50% inhibitory concentrations of garenoxacin, sparfloxacin, moxifloxacin, gatifloxacin, and levofloxacin were 10.1, 47.5, 39.6, 64.2, and 156.9 microg/ml, respectively, and the MICs against C. pneumoniae TW-183 were 0.008, 0.016, 0.063, 0.125, and 0.25 microg/ml, respectively.