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Drug-Target Interaction

Drug

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PubChem ID:6009
Structure:
Synonyms:
(Dimethylamino)phenazone
1,5-Dimethyl-4-dimethylamino-2-phenyl-3-pyrazolone
1-Phenyl-2,3-dimethyl-4-(dimethylamino)-5-pyrazolone
1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazol-5-one
1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazolone-5
144574-10-7
2,3-Dimethyl-4-dimethylamino-1-phenyl-5-pyrazolone
3-keto-1,5-dimethyl-4-dimethylamino-2-phenyl -2,3-dihydropyrazole
3-keto-1,5-Dimethyl-4-dimethylamino-2-phenyl-2,3-dihydropyrazole
3-Pyrazolin-5-one, 4-(dimethylamino)-2,3-dimethyl-1-phenyl-
3H-Pyrazol-3-one, 4-(dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-
4-(Dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one
4-(dimethylamino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
4-(dimethylamino)-1,5-dimethyl-2-phenylpyrazol-3-one
4-(dimethylamino)-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
4-(Dimethylamino)antipyrine
4-dimethylamino-1,5-dimethyl-2-phenylpyrazol-3-one
4-Dimethylamino-1-phenyl-2,3-dimethylpyrazolone
4-Dimethylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
4-Dimethylamino-2,3-dimethyl-1-phenyl-5-pyrazolone
4-Dimethylaminoantipyrine
4-Dimethylaminophenazone
58-15-1
AC-12025
AC1L1LLO
AC1Q6IGT
AKOS001590378
Amidazofen
Amidazophen
Amidazophene
Amidazophenum
Amidofebrin
Amidofen
Amidophen
Amidophenazon
Amidophenazone
Amidopyrazoline
Amidopyrin
Amidopyrine
Amidopyrinum
Aminofenazona
Aminofenazona [INN-Spanish]
Aminofenazone
Aminofenazone [Italian]
Aminophenazon
Aminophenazon [German]
Aminophenazone
Aminophenazone (INN)
Aminophenazone Berlin-Chemie Brand
Aminophenazonum
Aminophenazonum [INN-Latin]
Aminopyrene
Aminopyrin
Aminopyrine
Aminopyrine (JAN)
Aminopyrine [JAN]
aminopyrine(jan)
Aminopyrinum
Anafebrina
Antipyrine, 4-(dimethylamino)-
AR-1H7059
Berlin Chemie Brand of Aminophenazone
Berlin-Chemie Brand of Aminophenazone
BPBio1_000018
BRD-K12568846-001-04-7
Brufaneuxol
BSPBio_000016
C07539
C13H17N3O
CAS-58-15-1
CCG-103785
CCRIS 2907
CHEBI:160246
CHEMBL288470
D000632
D00556
D8015_SIGMA
DB01424
Dereuma
Dimapyrin
Dimethyl N aminoantipyrine
Dimethyl-N-aminoantipyrine
dimethylamino phenyldimethylpyrazolone
Dimethylamino-analgesine
dimethylaminoanalgesine
Dimethylaminoantipyrine
Dimethylaminoazophene
Dimethylaminophenazon
Dimethylaminophenazon [German]
Dimethylaminophenazone
Dimethylaminophenyldimethylpyrazolin
Dimethylaminophenyldimethylpyrazolone
Dipirin
Dipyrin
Dipyrine
EINECS 200-365-8
Eufibron
Febrinina
Febron
HMS1536B11
HMS1568A18
HMS2092E10
HMS2095A18
HSDB 2135
Hyparon
I14-7750
Itamidone
LS-239
Mamallet-A
MLS002154195
NCGC00016257-01
NCGC00016257-02
NCGC00016257-03
NCGC00016257-04
NCGC00016257-05
NCGC00016257-06
NCGC00016257-07
NCGC00090878-01
NCGC00090878-02
NCGC00090878-03
NCGC00175173-01
NCGC00175173-02
Netsusarin
Novamidon
NSC 4993
NSC4993
Oprea1_080671
Piramidon
Pirazon
Piridol
Piromidina
Polinalin
Prestwick0_000088
Prestwick1_000088
Prestwick2_000088
Prestwick3_000088
Prestwick_14
Pyradone
Pyramidon
Pyramidone
SMR001216566
SPBio_001955
ST011911
TimTec1_000737
UNII-01704YP3MO
WLN: T5NNVJ A1 BR& DN1&1 E1
ZINC00057115
ATC-Codes:

Target

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Uniprot ID:CP1A2_HUMAN
Synonyms:
CYPIA2
Cytochrome P450 1A2
P(3)450
P450 4
P450-P3
EC-Numbers:1.14.14.1
Organism:Homo sapiens
Human
PDB IDs:2HI4
Structure:
2HI4

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----
----
----

References:

10199594
11853173
Inhibition of human hepatic cytochrome P450s and steroidogenic CYP17 by nonylphenol.. Toshiro Niwa; Yumi Maekawa; Megumi Fujimoto; Kae Kishimoto; Yoshiyasu Yabusaki; Fumihide Ishibashi; Masanao Katagiri (2002) Biological & pharmaceutical bulletin display abstract
Effect of nonylphenol on aminopyrine N-demethylase activity, a typical drug-metabolizing enzyme activity, by ten kinds of human hepatic cytochrome P450s (CYP) and on progesterone 17alpha-hydroxylase activity by steroidogenic CYP17 was investigated. When determined at 2 mM substrate concentration, nonylphenol (1 mM) most efficiently inhibited aminopyrine N-demethylation by CYP2C9 and CYP2C19, by 61% and 59%, respectively, followed by CYP2D6, CYP1A2, CYP2C18 and CYP2C8 (46-51%), whereas inhibition of the activities by other CYPs was less than 27%. Additionally, nonylphenol competitively inhibited diclofenac 4'-hydroxylation by CYP2C9 and S-mephenytoin 4'-hydroxylation by CYP2C19 with Ki values of 5.3 and 37 microM, respectively. Furthermore, nonylphenol exhibited a competitive inhibition of progesterone 17alpha-hydroxylase activity by CYP17 with Ki value of 62 microM. These results suggest that nonylphenol inhibits human hepatic CYPs, especially CYP2C9 and CYP2C19, and steroidogenic CYP17 activities.
11996015