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Drug-Target Interaction

Drug

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PubChem ID:5959
Structure:
Synonyms:
137731-90-9
15313-32-3
2,2-Dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-(hydroxy(oxido)amino)phenyl)ethyl)acetamide, (1R, 2R)-
2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl
2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
2,2-Dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
23276_FLUKA
2787-09-9
4-13-00-02742 (Beilstein Handbook Reference)
442513_SUPELCO
55172-72-0
56-75-7
59112-59-3
85666-84-8
AB00374860
Acetamide, 2,2-dichloro-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-
acetamide, 2,2-dichloro-n-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-, (r*,r*)-(+)-
Acetamide, 2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-, (R*,R*)-(+-)-
Acetamide, 2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-, (R-(R*,R*))-
Acetamide, 2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-, (theta-(theta,theta))-
Acetamide, 2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)-, D-(-)-threo-
Acetamide, 2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)-,D-(-)-threo-
Acetamide, 2,2-dichloro-N-[.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-nitrophenethyl]
Acetamide, 2,2-dichloro-N-[.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-nitrophenethyl]-, D-threo-(-)-
Acetamide, 2,2-dichloro-N-[.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-nitrophenethyl]-,D-(-)-threo-
Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-, [R-(R*,R*)]-
AI3-25003
AIDS-019445
AIDS-110811
AIDS019445
AIDS110811
Ak-chlor
Alficetyn
Ambofen
Amphenicol
Amphicol
Amseclor
Anacetin
Aquamycetin
Austracil
Austracol
Biocetin
Biophenicol
BPBio1_000135
BRN 2225532
BSPBio_000121
C.A.F
C0378_SIGMA
C0857_SIGMA
C11H12Cl2N2O5
C1863_SIGMA
C1919_SIGMA
C7795_SIGMA
CAF
CAF (pharmaceutical)
CAM
CAP
CAP (ambiguous)
Catilan
CCRIS 3922
Ch loramex
CHEBI:17698
Chemiceticol
Chemicetin
Chemicetina
Chlomin
Chlomycol
Chlora-Tabs
Chloramex
Chloramfenikol
Chloramfenikol [Czech]
Chloramficin
Chloramfilin
CHLORAMPHENICOL
Chloramphenicol & VRC3375
CHLORAMPHENICOL (SEE ALSO CHLORAMPHENICOL NA SUCCINATE 982-57-0)
Chloramphenicol crystalline
Chloramphenicol [BAN:INN:JAN]
Chloramphenicol [INN:BAN:JAN]
Chloramphenicol, d-
Chloramphenicolum
Chloramphenicolum [INN-Latin]
Chloramsaar
Chlorasol
Chlorbiotic (Veterinary)
Chloricol
Chlormycetin R
Chlornitromycin
Chloro-25 vetag
Chloroamphenicol
Chlorocaps
Chlorocid
Chlorocid S
Chlorocide
Chlorocidin C
Chlorocidin C tetran
Chlorocol
CHLOROFAIR
Chloroject L
Chloromax
Chloromycetin
CHLOROMYCETIN HYDROCORTISONE
Chloromycetin®
Chloromycetny [Polish]
Chloromyxin
Chloronitrin
Chloroptic
CHLOROPTIC S.O.P
Chloroptic S.O.P.
CHLOROPTIC-P S.O.P
Chlorovules
Chlorsig
Cidocetine
Ciplamycetin
CLM
Cloramfen
Cloramfenicol
Cloramfenicol [INN-Spanish]
Cloramfenicolo
Cloramfenicolo [DCIT]
Cloramficin
Cloramical
Cloramicol
Cloramidina
Cloranfenicol
Cloroamfenicolo [Italian]
Clorocyn
Cloromisan
Cloromissan
Clorosintex
Comycetin
CPh
Cylphenicol
D(-)-threo-2-dichloroacetamido-1-p-nitrophen yl-propanediol
D(-)-threo-2-Dichloroacetamido-1-p-nitrophenyl-1,3-propanediol
D(-)-threo-2-dichloroacetamido-1-p-nitrophenyl-propanediol
D(-)-threo-Chloramphenicol
D-( -)-threo-1-(p-nitrophenyl)-2-dichloroacetamido-1,3-propanediol
D-(-)-2,2-Dichloro-N-(.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-nitrophenyl-ethyl)acetamide
D-(-)-2,2-Dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenylethyl)acetamide
D-(-)-Chloramphenicol
D-(-)-threo-1-(4-Nitrophenyl)-2-dichloroacetamido-1,3-propanediol
D-(-)-threo-1-(p-nitrophenyl)-2-dichloroacetamido-1,3-propanediol
D-(-)-threo-1-p-Nitrophenyl-2-dichloracetamido-1,3-propanediol
D-(-)-threo-1-p-Nitrophenyl-2-dichloroacetylamino-1,3-propanediol
D-(-)-threo-2,2-Dichloro-N-[.beta.-hydroxy-.alpha.-(hydroxymethyl)]-p-nitrophenethylacetamide
D-(-)-threo-2,2-Dichloro-N-[beta-hydroxy-alpha-(hydroxy-methyl)-p-nitrophenethyl]acetamide
D-(-)-threo-2,2-Dichloro-N-[beta-hydroxy-alpha-(hydroxymethyl)-beta-(4-nitrophenyl)ethyl]acetamide
D-(-)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol
D-(-)-threo-2-Dichloroacetamido-1-p-nitrophenyl-1,3-propanediol
D-(-)-threo-alpha, alpha-Dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)acetamide
D-(-)-threo-Chloramphenicol
D-2-DICHLOROACETAMIDO-1-p-NITRO-PHENYL-1,3-PROPANEDIOL
D-Chloramphenicol
D-threo-(-)-2,2-Dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)acetamide
D-threo-(1R,2R)-1-p-Nitrophenyl-2-dichloroacetamido-1,3-propanediol
D-threo-1-(p-Nitrophenyl)-2-(dichloroacetylamino)-1,3-propanediol
D-threo-2,2-Dichloro-N-[beta-hydroxy-alpha-(hydroxymethyl)-4-nitrophenethyl]acetamide
D-threo-Chloramphenicol
D-threo-N-(1,1'-Dihydroxy-1-p-nitrophenylisopropyl)dichloroacetamide
D-threo-N-dichloroacetyl-1-p-nitrophenyl-2-amino-1,3-propane-diol
D-threo-N-Dichloroacetyl-1-p-nitrophenyl-2-amino-1,3-propanediol
Desphen
Detreomycin
Detreomycine
Dextromycetin
DivK1c_000544
Doctamicina
Duphenicol
Econochlor
EINECS 200-287-4
Elase-Chloromycetin
Embacetin
Emetren
Enicol
Enteromycetin
Erbaplast
Ertilen
F armicetina
Farmicetina
Fenicol
Globenicol
Glorous
Halomycetin
Hortfenicol
HSDB 3027
I 337A
IDI1_000544
inhibits protein synthesis
Interomycetine
Intramycetin
Intramyctin
Isicetin
Ismicetina
Isophenicol
Isopto fenicol
Juvamycetin
Kamaver
KBio1_000544
Kemicetina
Kemicetine
Kloramfenikol
Klorita
Klorocid S
Laevomycetinum
Leukamycin
Leukomyan
Leukomycin
Levomicetina
Levomitsetin
Levomycetin
Loromicetina
Loromisan
Loromisin
LS-225
Mastiphen
Mediamycetine
Medichol
Micloretin
Micochlorine
Micoclorina
Microcetina
Mixture Name
MLS001055372
MLS001066397
MLS001332385
MLS001332386
Mychel
Mychel-Vet
Mycinol
Myscel
NCGC00091011-01
NCGC00091011-02
NCGC00091011-03
NCGC00091011-04
NCI-C55709
NCI60_002620
NINDS_000544
Normimycin V
Novochlorocap
Novomycetin
Novophenicol
NSC 16331
NSC 3069
NSC16331
NSC3069
Oftalent
Oleomycetin
Opclor
Opelor
Ophthochlor
Ophthocort
Ophtochlor
OPTOMYCIN
Otachron
Otophen
Pantovernil
Paraxin
Pentamycetin
Prestwick3_000031
Quemicetina
Rivomycin
Romphenil
Ronfenil
Ronphenil
Septicol
Sificetina
Sintomicetina
Sintomicetine R
SMP1_000065
SMR000471851
Sno Phenicol
Sno-Phenicol
ST024743
Stanomycetin
Synthomycetin
Synthomycetine
Synthomycine
Syntomycin
Tea-Cetin
Tega-Cetin
Tevcocin
Tevcosin
Tifomycin
Tifomycine
Tiromycetin
Treomicetina
U-6062
Unimycetin
Veticol
Vice ton
Viceton
WLN: WNR DYQY1QMVYGG
ZINC00113382
ATC-Codes:

Target

show target details
Uniprot ID:CP2CJ_HUMAN
Synonyms:
(R)-limonene 6-monooxygenase
(S)-limonene 6-monooxygenase
(S)-limonene 7-monooxygenase
CYPIIC17
CYPIIC19
Cytochrome P450 2C19
Mephenytoin 4-hydroxylase
P450-11A
P450-254C
EC-Numbers:1.14.13.48
1.14.13.49
1.14.13.80
Organism:Homo sapiens
Human
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----
----

References:

14576103
Chloramphenicol is a potent inhibitor of cytochrome P450 isoforms CYP2C19 and CYP3A4 in human liver microsomes.. Ji-Young Park; Kyoung-Ah Kim; Su-Lyun Kim (2003) Antimicrobial agents and chemotherapy display abstract
The inhibitory effect of chloramphenicol on human cytochrome P450 (CYP) isoforms was evaluated with human liver microsomes and cDNA-expressed CYPs. Chloramphenicol had a potent inhibitory effect on CYP2C19-catalyzed S-mephytoin 4'-hydroxylation and CYP3A4-catalyzed midazolam 1-hydroxylation, with apparent 50% inhibitory concentrations (inhibitory constant [K(i)] values are shown in parentheses) of 32.0 (7.7) and 48.1 (10.6) microM, respectively. Chloramphenicol also weakly inhibited CYP2D6, with an apparent 50% inhibitory concentration (K(i)) of 375.9 (75.8) microM. The mechanism of the drug interaction reported between chloramphenicol and phenytoin, which results in the elevation of plasma phenytoin concentrations, is clinically assumed to result from the inhibition of CYP2C9 by chloramphenicol. However, using human liver microsomes and cDNA-expressed CYPs, we showed this interaction arises from the inhibition of CYP2C19- not CYP2C9-catalyzed phenytoin metabolism. In conclusion, inhibition of CYP2C19 and CYP3A4 is the probable mechanism by which chloramphenicol decreases the clearance of coadministered drugs, which manifests as a drug interaction with chloramphenicol.
SuperCyp