Home
Drugs
Targets
Pathways
Ontologies
Cyp450s
Adv.search
Help/FAQ

Drug-Target Interaction

Drug

show drug details
PubChem ID:5953
Structure:
Synonyms:
()-quinidine
(+)-Quinidine
(8R,9S)-6'-Methoxycinchonan-9-ol
(8R,9S)-Quinidine
(9S)-6'-Methoxycinchonan-9-ol
(9S)-6-Methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol
(S)-[(2R,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4
11010-73-4
56-54-2
AC1L1LHL
alpha-(6-Methoxy-4-quinolyl)-5-vinyl-2-quinuclidinemethanol (9S)-
beta-Quinine
BRD-A17470778-001-02-9
BSPBio_001467
C06527
C20H24N2O2
CCRIS 672
CHEMBL21578
Chinidin
Chinidin [German]
Cinchonan-9-ol, 6'-methoxy-, (9S)-
Conchinin
Conquinine
D08458
EINECS 200-279-0
GNF-PF-5459
HMS1989J09
HSDB 225
Kinidin (TN)
Lopac0_001009
LS-221
NCI-C56246
Pitayine
Prestwick0_000280
Prestwick1_000280
Prestwick2_000280
QUINIDINE
Quinidine (BAN)
Quinidine Sulfate
Quinidine [BAN]
Quinora
SPBio_002379
UNII-ITX08688JL
ATC-Codes:

Target

show target details
Uniprot ID:CP1A2_HUMAN
Synonyms:
CYPIA2
Cytochrome P450 1A2
P(3)450
P450 4
P450-P3
EC-Numbers:1.14.14.1
Organism:Homo sapiens
Human
PDB IDs:2HI4
Structure:
2HI4

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

11765139
Differential inhibition of human CYP1A1 and CYP1A2 by quinidine and quinine.. M S Ching; C L Blake; N A Malek; P W Angus; H Ghabrial (2001) Xenobiotica; the fate of foreign compounds in biological systems display abstract
1. The inhibition of recombinant CYP1A1 and CYP1A2 activity by quinidine and quinine was evluated using ethoxyresorutin O-deethylation, phenacetin O-deethylation and propranolol desisopropylation as probe catalytic pathways. 2. With substrate concentrations near the Km of catalysis, both quinidine and quinine potently inhibited CYP1A1 activity with [I](0.5) approximately 1-3 microM, whereas in contrast, there was little inhibition of CYP1A2 activity. The Lineweaver-Burk plots with varying inhibitor concentrations suggested that inhibition by quinidine and quinine was competitive. 3. There was only trace metabolism of quinidine by recombinant CYP1A1, whereas rat liver microsomes as a control showed extensive consumption of quinidine and metabolite production. 4. This work suggests that quinidine is a non-classical inhibitor of CYP1A1 and that it is not as highly specific at inhibiting CYP2D6 as previously thought.