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Drug-Target Interaction

Drug

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PubChem ID:5936
Structure:
Synonyms:
2-(fluoro-propan-2-yloxyphosphoryl)oxypropane
2-[fluoro(propan-2-yloxy)phosphoryl]oxypropane
37209-35-1
38399_FLUKA
4-01-00-01480 (Beilstein Handbook Reference)
55-91-4
AC1L1LGC
Bis(1-methylethyl) Phosphorofluoridate
bis(propan-2-yl) fluorophosphate
BRN 1723307
C00202
C6H14FO3P
CHEBI:17941
CHEMBL1025
D00043
D007531
D0879_SIGMA
DB00677
DFP
Di isopropylphosphorofluoridate
Di-isopropylphosphorofluoridate
Diflupyl
Diflurophate
DIFP
Diisopropoxyphosphoryl fluoride
diisopropyl fluoridophosphate
Diisopropyl fluorophosphate
Diisopropyl fluorophosphonate
Diisopropyl phosphofluoridate
Diisopropyl phosphorofluoridate
DIISOPROPYL-FLUOROPHOSPHATE
Diisopropylfluorfosfat
Diisopropylfluorfosfat [Czech]
Diisopropylfluorophosphate
Diisopropylfluorophosphoric acid ester
Diisopropylfluorphosphorsaeureester
Diisopropylfluorphosphorsaeureester [German]
Diisopropylphosphofluoridate
Diisopropylphosphorofluoridate
dipropan-2-yl phosphorofluoridoate
Disiopropyl fluorophosphonate
Dyflos
EA 1152
EINECS 200-247-6
Floropryl
Floropryl (TN)
Fluophosphoric acid, diisopropyl ester
Fluorodiisopropyl phosphate
Fluorophosphoric acid, diisopropyl ester
Fluoropryl
Fluorostigmine
Fluostigmine
Fluropryl
HSCI1_000366
HSDB 2133
Isofluorophate
Isofluorphate
Isoflurophate
Isoflurophate (USP)
Isoflurophate [USP]
Isoflurophosphate
Isopropyl fluophosphate
Isopropyl phosphorofluoridate
LS-108313
Merck Brand of Isoflurophate
NCGC00168783-01
nchembio.70-comp11
Neoglaucit
O,O'-Diisopropyl phosphoryl fluoride
O,O-Diisopropyl fluorophosphate
PDSP1_000466
PDSP2_000464
PF-3
Phosphoric acid diisopropyl ester fluoride
Phosphorofluoridic acid, bis(1-methylethyl) ester
Phosphorofluoridic acid, diisopropyl ester
RCRA waste no. P043
RCRA waste number P043
T-1703
TL 466
UNII-12UHW9R67N
ATC-Codes:

Target

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Uniprot ID:ACES_RAT
Synonyms:
Acetylcholinesterase
AChE
EC-Numbers:3.1.1.7
Organism:Rat
Rattus norvegicus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

2610946
Effects of diisopropylfluorophosphate on brain acetylcholinesterase, butyrylcholinesterase, and neurotoxic esterase in rats.. D K Lim; B Hoskins; I K Ho (1989) Biomedical and environmental sciences : BES display abstract
The inhibition and the recovery of brain AChE, BuChE, and NTE activities after acute and subacute administration of DFP were studied in the rat. DFP displayed different specificities in inhibiting these enzymes; inhibition was greatest for BuChE followed by AChE and NTE. Recovery was most rapid for BuChE followed by NTE and AChE. The recovery rates of AChE and BuChE following acute and subacute treatment were similar. However, the recovery rate of NTE in subacutely treated rats was significantly faster than that in acutely treated rats. The results suggest that DFP inhibits these three enzymes and the rates of regeneration of these enzymes are significantly different.