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Drug-Target Interaction

Drug

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PubChem ID:5881
Structure:
Synonyms:
()-dehydroisoandrosterone
(+)-Dehydroisoandrosterone
(1S,5S,11S,15S,2R,10R)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0<2,7>.0<11
(3-beta)-3-Hydroxyandrost-5-en-17-one
(3beta)-3-hydroxyandrost-5-en-17-one
(3beta)-3-Hydroxyandrost-5-ene-17-one
17-Chetovis
17-Hormoforin
1A9D2040-240C-427D-ADE4-0CB700B785CB
3-beta-hydroxy-5-androsten-17-on
3-beta-Hydroxy-5-androsten-17-one
3-beta-hydroxyandrost-5-en-17-one
3.beta.-Hydroxyandrost-5-en-17-one
3beta-hydroxy-5-androsten-17-one
3beta-Hydroxy-D5-androsten-17-one
3beta-Hydroxyandrost-5-en-17-one
3beta-Hydroxyandrost-5-ene-17-one
4-08-00-00994 (Beilstein Handbook Reference)
5,6-Dehydroisoandrosterone
5,6-Dehydroisoandrostorone
5,6-Didehydroisoandrosterone
5-Androsten-3beta-ol-17-one
5-Dehydroepiandrosterone
53-43-0
AC-10442
AC1L1LC4
AIDS-000133
AIDS000133
Anastar
AND
Andrestenol
Androst-5-en-17-one, 3-beta-hydroxy-
Androst-5-en-17-one, 3-hydroxy-, (3-beta)-
Androst-5-en-17-one, 3-hydroxy-, (3-beta)- (9CI)
Androst-5-en-17-one, 3-hydroxy-, (3.beta.)-
Androst-5-en-17-one, 3-hydroxy-, (3beta)-
Androst-5-en-17-one, 3-hydroxy-, (3beta)- (9CI)
Androst-5-en-17-one, 3.beta.-hydroxy-
Androst-5-en-17-one, 3beta-hydroxy-
Androst-5-en-17-one, 3beta-hydroxy- (8CI)
Androst-5-ene-3beta-ol-17-one
Androstenol
Androstenolone
Aslera
Astenile
BIDD:PXR0080
Biolaif (TN)
bmse000665
BRN 2058110
C01227
C19H28O2
Caswell No. 051F
CCG-101190
CCRIS 3277
CHEBI:28689
CHEMBL90593
CMC_13435
CPD000059075
D 4000
D-0340
D0044
D08409
D4000_SIGMA
D5-Androsten-3beta-ol-17-one
DB01708
Deandros
Dehydro-epi-androsterone
Dehydroepiandrosterone
Dehydroepiandrosterone, DHEA
Dehydroepiandrosterone-Supplied by Selleck Chemicals
Dehydroisoandrosterone
Delta5-androsten-3-beta-ol-17-one
DHA
DHEA
Diandron
Diandrone
EINECS 200-175-5
EL-10
EPA Pesticide Chemical Code 126510
Epiandrosterone, 5-dehydro-
EU-0100368
Fidelin
Fidelin T
GL 701
GL-701
GL701
HMS2052P11
HMS2090C04
HMS2232K11
Hydroxyandrost-5-en-17-one
IM 28
Inflabloc
IP-1001
IPL-1001
LMST02020021
Lopac0_000368
LS-7296
MLS001066350
MLS001333231
MLS001333232
MLS001424274
NCI60_042215
NSC 9896
NSC9896
PB-007
Prasterona
Prasterona [INN-Spanish]
Prasterone
Prasterone (INN)
Prasterone [INN]
Prasteronum
Prasteronum [INN-Latin]
Prestara
Psicosterone
S2460_Selleck
SAM001246922
SBB012501
SH-K-04828
Siscelar plus
SMR000059075
ST069381
trans-de-hydroandrosterone
trans-Dehydroandrosterone
UNII-459AG36T1B
Vaginorm
ZINC03807917
ATC-Codes:

Target

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Uniprot ID:CP1A1_HUMAN
Synonyms:
CYPIA1
Cytochrome P450 1A1
P450 form 6
P450-C
P450-P1
EC-Numbers:1.14.14.1
Organism:Homo sapiens
Human
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----
----
----

References:

10575002
The steroid hormone dehydroepiandrosterone inhibits CYP1A1 expression in vitro by a post-transcriptional mechanism.. H P Ciolino; G C Yeh (1999) The Journal of biological chemistry display abstract
The adrenal steroid hormone dehydroepiandrosterone (DHEA) is a potent inhibitor of mammary carcinogenesis induced by polycyclic aromatic hydrocarbons (PAH), though its mechanism is unclear. We examined the effect of DHEA on the expression of the carcinogen-activating enzyme cytochrome P450 1A1 (CYP1A1) in MCF-7 human breast epithelial carcinoma cells. DHEA inhibited the increase in CYP1A1 enzyme activity that occurs when MCF-7 cells are exposed to the PAH dimethylbenzanthracene (DMBA) or 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD). However, DHEA did not directly inhibit enzyme activity as it had no effect when added to the cells after induction by DMBA or TCDD. We observed that the increase of CYP1A1 mRNA in MCF-7 cells caused by DMBA or TCDD was inhibited by DHEA in a concentration-dependent manner. However, DHEA did not inhibit CYP1A1 promoter-driven transcription, indicating that it did not affect the aryl hydrocarbon receptor, which regulates transcription of the CYP1A1 gene. Actinomycin D chase experiments showed that DHEA caused a time- and concentration-dependent decrease in CYP1A1 mRNA levels, indicating that DHEA inhibits CYP1A1 expression by decreasing CYP1A1 mRNA stability. These data demonstrate that DHEA inhibits PAH-induced CYP1A1 mRNA expression and enzyme activity in vitro by a post-transcriptional mechanism. This regulation of the expression of carcinogen-activating enzymes may be responsible for the chemopreventive activity of DHEA and may be one of its physiologic functions in vivo.
12704664
9830688