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Drug-Target Interaction

Drug

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PubChem ID:5816
Structure:
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-Adrenalin
(-)-adrenaline
(-)-Epinephrine
(-)-Epinephrine bitartrate
(-)-R-Epinephrine
(R)-(-)-3,4-Dihydroxy-alpha-(methylaminomethyl)benzyl alcohol
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
02252_FLUKA
1,2-Benzenediol, 4-((1R)-1-hydroxy-2-(methylamino)ethyl)-
1,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-
1,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, (R)-
1,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, (theta)-
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
4-[(1R)-1-hydroxy-2-methylaminoethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
Adnephrine
ADR Adrenaline
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin Chloride
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline Bitartrate
Adrenaline Hydrochloride
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
ADROP
AI3-19015
AIDS-122802
AIDS122802
ALPHACAINE HCL W/ EPINEPHRINE
Ana-Guard
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
Balmadren
Benzyl alcohol, 3,4-dihydroxy-alpha-((methylamino)methyl)-, (-)-
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
BUPIVACAINE HCL AND EPINEPHRINE
C00788
C9H13NO3
CCRIS 4812
CHEBI:28918
Chelafrin
Citanest Forte
Corisol
D-Adrenaline
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
DURANEST
Dylephrin
Dyspne-inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
EPINEPHRINE
EPINEPHRINE (SEE ALSO: EPINEPHRINE HYDROCHLORIDE (CAS 55-31-2))
Epinephrine (USP/INN)
Epinephrine Bitartrate
Epinephrine hydrochloride
Epinephrine Hydrogen Tartrate
Epinephrine [USAN:INN:JAN]
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
EPIPEN E Z PEN
Epipen EZ Pen
EPIPEN JR
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
Glaucon
Glaucosan
Glauposine
Glycirenan
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
HSCI1_000215
HSDB 4289
Hypernephrin
Hyporenin
Intranefrin
IONTOCAINE
IOP
Isoptoepinal
Kidoline
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenalin
L-Adrenaline
L-Adrenaline Base
L-Adrenaline, L-Adrenaline, Adrenaline, d-Adrenaline, Adnephrine,
L-Epinehphrine
L-Epinephine
l-Epinephrine
l-Epinephrine (synthetic)
l-Epirenamine
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
LIDOCAINE HCL AND EPINEPHRINE
LIDOCAINE HCL W/ EPINEPHRINE
LIDOCATON
Lopac-E-4642
LS-156
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
Mixture Name
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
nchembio747-comp9
Nephridine
Nieraline
NSC 62786
NSC62786
NSC62786 (FREE BASE)
OCTOCAINE
Paranephrin
PDSP1_001120
PDSP2_001104
Primatene
Primatene Mist
PROCAINE HCL W/ EPINEPHRINE
R-(-)-Epinephrine
R-Adrenaline
Racemic Epinephrine
Racepinefrina [inn-spanish]
Racepinefrine
Racepinefrinum [inn-latin]
Racepinephrine
RCRA waste no. P042
RCRA waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SBB012384
Scurenaline
SEPTOCAINE
Simplene
Sindrenina
SMP1_000227
Soladren
Sphygmogenin
ST069368
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
SUS-PHRINE SULFITE-FREE
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
XYLOCAINE W/ EPINEPHRINE
ATC-Codes:

Target

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Uniprot ID:CP2C9_HUMAN
Synonyms:
(R)-limonene 6-monooxygenase
(S)-limonene 6-monooxygenase
(S)-limonene 7-monooxygenase
CYPIIC9
Cytochrome P450 2C9
P-450MP
P450 MP-4/MP-8
P450 PB-1
S-mephenytoin 4-hydroxylase
EC-Numbers:1.14.13.48
1.14.13.49
1.14.13.80
Organism:Homo sapiens
Human
PDB IDs:1OG2 1OG5 1R9O
Structure:
1R9O

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

11207028
Inhibition of cytochrome P450 2C9 activity in vitro by 5-hydroxytryptamine and adrenaline.. G Gervasini; C Martínez; J A Agúndez; F J García-Gamito; J Benítez (2001) Pharmacogenetics display abstract
In the present study, the occurrence of a modulatory effect of 14 neurotransmitters, precursors and metabolites on the cytochrome P450 2C9 (CYP2C9) enzyme activity, as determined by diclofenac 4-hydroxylation, was studied in human liver microsomes. Two indoleamines, 5-hydroxytryptamine (5-HT) and adrenaline, showed a non-competitive-type inhibitory effect of approximately 90% of the diclofenac 4-hydroxylase activity, with Ki values of 63.5 (0.7 and 156 (89.3 microM, respectively. The rest of substances analysed were weak inhibitors or had no inhibitory effect. CYP2C subfamily is present in human brain, although CYP2C9 isozyme has not yet been identified in this tissue, and CYP2C9 is involved in the metabolism of psychoactive drugs. Therefore, the fact that endogenous compounds could modulate the CYP2C9 activity, suggests that an hypothetical local activity of brain CYP2C9 might be susceptible to regulatory mechanisms. The possible clinical implications of this modulation are discussed.