Home
Drugs
Targets
Pathways
Ontologies
Cyp450s
Adv.search
Help/FAQ

Drug-Target Interaction

Drug

show drug details
PubChem ID:5816
Structure:
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-Adrenalin
(-)-adrenaline
(-)-Epinephrine
(-)-Epinephrine bitartrate
(-)-R-Epinephrine
(R)-(-)-3,4-Dihydroxy-alpha-(methylaminomethyl)benzyl alcohol
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
02252_FLUKA
1,2-Benzenediol, 4-((1R)-1-hydroxy-2-(methylamino)ethyl)-
1,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-
1,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, (R)-
1,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, (theta)-
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
4-[(1R)-1-hydroxy-2-methylaminoethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
Adnephrine
ADR Adrenaline
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin Chloride
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline Bitartrate
Adrenaline Hydrochloride
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
ADROP
AI3-19015
AIDS-122802
AIDS122802
ALPHACAINE HCL W/ EPINEPHRINE
Ana-Guard
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
Balmadren
Benzyl alcohol, 3,4-dihydroxy-alpha-((methylamino)methyl)-, (-)-
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
BUPIVACAINE HCL AND EPINEPHRINE
C00788
C9H13NO3
CCRIS 4812
CHEBI:28918
Chelafrin
Citanest Forte
Corisol
D-Adrenaline
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
DURANEST
Dylephrin
Dyspne-inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
EPINEPHRINE
EPINEPHRINE (SEE ALSO: EPINEPHRINE HYDROCHLORIDE (CAS 55-31-2))
Epinephrine (USP/INN)
Epinephrine Bitartrate
Epinephrine hydrochloride
Epinephrine Hydrogen Tartrate
Epinephrine [USAN:INN:JAN]
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
EPIPEN E Z PEN
Epipen EZ Pen
EPIPEN JR
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
Glaucon
Glaucosan
Glauposine
Glycirenan
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
HSCI1_000215
HSDB 4289
Hypernephrin
Hyporenin
Intranefrin
IONTOCAINE
IOP
Isoptoepinal
Kidoline
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenalin
L-Adrenaline
L-Adrenaline Base
L-Adrenaline, L-Adrenaline, Adrenaline, d-Adrenaline, Adnephrine,
L-Epinehphrine
L-Epinephine
l-Epinephrine
l-Epinephrine (synthetic)
l-Epirenamine
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
LIDOCAINE HCL AND EPINEPHRINE
LIDOCAINE HCL W/ EPINEPHRINE
LIDOCATON
Lopac-E-4642
LS-156
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
Mixture Name
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
nchembio747-comp9
Nephridine
Nieraline
NSC 62786
NSC62786
NSC62786 (FREE BASE)
OCTOCAINE
Paranephrin
PDSP1_001120
PDSP2_001104
Primatene
Primatene Mist
PROCAINE HCL W/ EPINEPHRINE
R-(-)-Epinephrine
R-Adrenaline
Racemic Epinephrine
Racepinefrina [inn-spanish]
Racepinefrine
Racepinefrinum [inn-latin]
Racepinephrine
RCRA waste no. P042
RCRA waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SBB012384
Scurenaline
SEPTOCAINE
Simplene
Sindrenina
SMP1_000227
Soladren
Sphygmogenin
ST069368
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
SUS-PHRINE SULFITE-FREE
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
XYLOCAINE W/ EPINEPHRINE
ATC-Codes:

Target

show target details
Uniprot ID:CP1A2_HUMAN
Synonyms:
CYPIA2
Cytochrome P450 1A2
P(3)450
P450 4
P450-P3
EC-Numbers:1.14.14.1
Organism:Homo sapiens
Human
PDB IDs:2HI4
Structure:
2HI4

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

9682270
Modulation of CYP1A2 enzyme activity by indoleamines: inhibition by serotonin and tryptamine.. J A Agúndez; L Gallardo; C Martínez; G Gervasini; J Benítez (1998) Pharmacogenetics display abstract
Recent evidence supports a role for the CYP2D6 enzyme in the metabolism of tryptamine. Because of the partial overlapping between substrate and inhibitor specificities that characterize some cytochrome P450 enzymes, these finding raise the possibility that other cytochrome P450 enzymes may be modulated by endogenous compounds. In the present study, the occurrence of modulatory effect of 17 neurotransmitters, precursors and metabolites on the cytochrome P450 1A2 (CYP1A2) enzyme activity was studied in human liver microsomes. Two indoleamines, serotonin and tryptamine, showed a competitive inhibitory effect on the high-affinity component of the phenacetin O-de-ethylase activity. Both substances induced an inhibition of 100% of the activity, with Ki values of 35 and 45 microns for serotonin and tryptamine, respectively. The inhibitors did not affect the microsomal NADPH-reductase activity. Other substances, which were either poor or partial inhibitors, were dopamine, L-tyrosine, tryptophol, 5-hydroxytryptophol, adrenaline, indole-3-acetaldehyde, 5-hydroxytryptophan, noradrenaline, vanillylmandelic acid, indole-3-acetic acid, dihydroxyphenylacetic acid, and homovanillic acid. L-tryptophan, dihydroxyphenylalanine and 5-hyroxyindole acetic acid induced very low or no inhibitory effect. Tryptamine and serotonin metabolism in human liver microsomes was studied after inhibition of monoamine oxidase activity with the unspecific MAO inhibitor pargyline. Both serotonin and tryptamine were metabolized in human liver microsomes. However, the metabolism of both indoleamines was not significantly inhibited with the CYP1A2-specific inhibitor furafylline, thus indicating that the inhibition of CYP1A2 was not related to metabolic activity of the CYP1A2 enzyme on serotonin or tryptamine. The CYP1A2 enzyme is expressed in brain and is involved in the metabolism of psychoactive drugs. Therefore, the fact that endogenous compounds could modulate the CYP1A2 activity suggests that local activity of brain CYP1A2 might be susceptible to local regulatory mechanisms. This may have important clinical implications, one of them being that CYP1A2 activity in brain tissue might correlate poorly with that of liver, as observed in vivo. In addition, the influence of indoleamines on CYP1A2 activity might be partly responsible for a number of associations of CYP1A2 activity with nutritional and environmental factors.