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Drug-Target Interaction

Drug

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PubChem ID:5717
Structure:
Synonyms:
107753-78-6
4-(5-cyclopentyloxy-carbonylamino-1-methyl-indol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide
4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide
4-(5-cyclopentyloxycarbonylamino-2-methylindol-3-yl-methyl)-3-methoxy-N-O-tolylsulfonylbenzamide
Accolate
Accolate (TN)
Accoleit
Aeronix
AstraZeneca brand of zafirlukast
C062735
C07206
C31H33N3O6S
Carbamic acid, (3-((2-methoxy-4-((((2-methylphenyl)sulfonyl)amino)carbonyl)phenyl)methyl)-1-methyl-1H-indol-5-yl)-, cyclopentyl ester
CHEBI:10100
CPD000466316
Cyclopentyl
cyclopentyl (1-methyl-3-{[2-(methyloxy)-4-({[(2-methylphenyl)sulfonyl]amino}carbonyl)phenyl]methyl}-1H-indol-5-yl)carbamate
Cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carbamoyl)benzyl)-1-methylindole-5-carbamate
cyclopentyl 3-[2-methoxy-4-(2-methylphenylsulfonylcarbamoyl)benzyl]-1-methyl-1H-indol-5-ylcarbamate
cyclopentyl N-[3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-methylindol-5-yl]carbamate
D00411
DB00549
ICI 204,219
ICI 204219
ICI-204219
LS-50025
Menarini brand of zafirlukast
MLS000759421
MLS001424064
NCGC00164547-01
Novartis brand of zafirlukast
Olmoran
Respix
SAM001246577
SMR000466316
STOCK6S-45610
Zafirlukast
Zafirlukast (JAN/USAN/INN)
Zafirlukast [USAN:BAN:INN]
Zafirst
Zeneca brand of zafirkulast
ZINC00896717
ATC-Codes:
Side-Effects:
Side-EffectFrequency
headache0.07071428
nausea0.0255
diarrhea0.024500001
pain0.018
asthenia0.017
dizziness0.0155
fever0.0135
back pain0.013499999
vomiting0.013
dyspepsia0.012500001
infection0.009375002
abdominal pain0.008714285
myalgia0.0067999996
bleeding disorders0.0010
insomnia0.0010
pruritus0.0010
thrombocytopenia0.0010
urticaria0.0010
vasculitis0.0010
elevated liver function tests0.0010
liver failure0.0010
neuropathy0.0010
rectal bleeding0.0010
malaise0.0010
neutropenia0.0010
hypersensitivity0.0010
agranulocytosis0.0010
urticaria angioedema0.0010
arthralgia0.0010
blistering0.0010
edema0.0010
eosinophilia0.0010
rash0.0010
haematemesis0.0010
hematological disorders0.0010
haemoptysis0.0010
bleeding0.0010
hepatitis0.0010
hyperbilirubinemia0.0010
eosinophilic pneumonia0.0010

Target

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Uniprot ID:CP1A2_HUMAN
Synonyms:
CYPIA2
Cytochrome P450 1A2
P(3)450
P450 4
P450-P3
EC-Numbers:1.14.14.1
Organism:Homo sapiens
Human
PDB IDs:2HI4
Structure:
2HI4

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: