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Drug-Target Interaction

Drug

show drug details
PubChem ID:5625
Structure:
Synonyms:
(1-(5-METHANSULPHONAMIDO-1H-INDOL-2-YL-CARBONYL)4-[METHYLAMINO)PYRIDINYL]PIPERAZINE
1-(3-((1-Methylethyl)amino)-2-pyridinyl)-4-((5-((methylsulfonyl)amino)-1H-
1-(3-((1-Methylethyl)amino)-2-pyridinyl)-4-((5-((methylsulfonyl)amino)-1H-indol-2-yl)carbonyl)piperazine
1-(5-Methanesulphonamido)-1H-indol-2-yl-carbonyl)-4-[3-(isopropylamino)-2-pyridinyl]piperazine
136817-59-9
147221-93-0
147221-93-0 (MESYLATE SALT)
2-(4-(5-Methanesulfonamido-1H-indol-2-ylcarbonyl)-1-piperazinyl)-N-(1-methylethyl)-3-pyridinamine
AIDS-005059
AIDS-086776
AIDS005059
AIDS086776
BHAP der
BHAP-U 90152
C06941
C22H28N6O3S
CHEBI:119573
DB00705
Delavirdine
Delavirdine (*Mesylate salt*)
Delavirdine (INN)
Delavirdine [INN]
Delavirdine(U-90152) & .a.IFN
DLV
LS-172972
N-[2-[4-[3-(propan-2-ylamino)pyridin-2-yl]piperazine-1-carbonyl]-1H-indol-5-yl]methanesulfonamide
N-{2-[(4-{3-[(1-methylethyl)amino]pyridin-2-yl}piperazin-1-yl)carbonyl]-1H-indol-5-yl}methanesulfonamide
NCGC00168776-01
Piperazine, 1-(3-((1-methylethyl)amino)-2-pyridinyl)-4-((5-((methylsulfonyl)amino)-1H-indol-2-yl)carbonyl)-
Piperazine, 1-[3-[(1-methylethyl)amino]-2-pyridinyl]-4-[[5-[(methylsulfonyl)amino]-1H-indol-2-yl]carbonyl]-
PNU-90152-T
Rescriptor
Rescriptor (TM)
SPP
U 90152
U-90152
U-90152S
U90152S (*Mesylate salt*)
ZINC18516586
ATC-Codes:
Side-Effects:
Side-EffectFrequency
rash0.107742466
hemolytic anemia0.0010
hepatic failure0.0010
stevens - johnson syndrome0.0010
rhabdomyolysis0.0010
acute kidney failure0.0010
erythema multiforme0.0010
anorexia0
neuropathy0
colitis0
dysphagia0
pancytopenia0
hyperkalemia0
palpitations0
tinnitus0
peripheral edema0
migraine0
muscle cramps0
hypertriglyceridemia0
toxic epidermal necrolysis0
amnesia0
rhinitis0
angioedema0
sebaceous cyst0
abdominal cramps0
somnolence0
polyuria0
petechiae0
fungal dermatitis0
ulcerative stomatitis0
heart failure0
hematuria0
folliculitis0
agitation0
cardiomyopathy0
weakness0
constipation0
stomatitis0
dry skin0
nervousness0
dyspepsia0
dermatitis0
exfoliative dermatitis0
influenza0
increased sweating0
diverticulitis0
enteritis0
ulcer0
eructation0
tachycardia0
euphoria0
abscess0
myalgia0
tenosynovitis0
verruca0
dry eyes0
peripheral vascular disorder0
anxiety0
vomiting0
arthralgia0
upper respiratory tract infection0
hallucinations0
emotional lability0
depressive symptoms0
cognitive dysfunction0
manic0
headache0
leg cramps0
eosinophilia0
arthritis0
hematospermia0
insomnia0
gastritis0
hepatitis0
thrombocytopenia0
toothache0
dental abscess0
amenorrhea0
otitis media0
proteinuria0
neutropenia0
amylase increased0
abdominal distention0
neck rigidity0
tetany0
postural hypotension0
tuberculosis0
fecal incontinence0
testicle pain0
dyspnea0
abdominal pain0
pancreatitis0
hypophosphatemia0
gum hemorrhage0
gastroesophageal reflux0
sialadenitis0
chest pain0
gastroenteritis0
photophobia0
jaundice0
anemia0
ecchymosis0
pain0
decreased libido0
hyponatremia0
hiccup0
bradycardia0
conjunctivitis0
alopecia0
syncope0
nausea0
metrorrhagia0
dry mouth0
blepharitis0
epididymitis0
epistaxis0
fever0
bilirubinemia0
diplopia0
ear pain0
back pain0
erythema0
kidney pain0
esophagitis0
impotence0
urticaria0
bone pain0
pruritus0
hyperuricemia0
hypertension0
muscle weakness0
urinary tract infection0
confusion0
lymphadenopathy0
paresthesia0
weight gain0
gastrointestinal hemorrhage0
flank pain0
bronchitis0
skin nodule0
nystagmus0
diarrhea0
vertigo0
asthenia0
breast enlargement0
moniliasis0
paralysis0
allergic reaction0
malaise0
glossitis0
vaginal moniliasis0
viral infection0
tremor0
herpes zoster0
hepatomegaly0
nocturia0
fatigue0
purpura0
chills0
blurred vision0
seborrhea0
sinusitis0
pneumonia0
gingivitis0
leukopenia0
cough0
flatulence0
hyperesthesia0
pharyngitis0
hypocalcemia0
leukocytoclastic vasculitis0
dizziness0
nightmares0
edema0
nail disorder0
hyperglycemia0
duodenitis0

Target

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Uniprot ID:POL_HV1H2
Synonyms:
Gag-Pol polyprotein
Pr160Gag-Pol
EC-Numbers:-
Organism:HIV-1
Human immunodeficiency virus type 1
isolate HXB2 group M subtype B
PDB IDs:1A30 1BV7 1BV9 1BVE 1BVG 1BWA 1BWB 1C0T 1C0U 1C1B 1C1C 1DMP 1DTQ 1DTT 1E6J 1EP4 1ESK 1EX4 1EXQ 1FB7 1FK9 1FKO 1FKP 1G6L 1HIV 1HVH 1HVR 1HWR 1HXB 1JKH 1JLA 1JLB 1JLC 1JLE 1JLF 1JLG 1JLQ 1KLM 1LV1 1LW0 1LW2 1LWC 1LWE 1LWF 1NCP 1O1W 1ODW 1ODY 1QBR 1QBS 1QBT 1QBU 1REV 1RT1 1RT2 1RT3 1RT4 1RT5 1RT6 1RT7 1RTD 1RTH 1RTI 1RTJ 1S1T 1S1U 1S1V 1S1W 1S1X 1T05 1TAM 1TKT 1TKX 1TKZ 1TL1 1TL3 1VRT 1VRU 2HND 2HNY 2HNZ 2NPH 2OPP 2OPQ 2OPR 2OPS 2RF2 2RKI 3C6T 3C6U 3DI6 3DLE 3DLG 3DM2 3DMJ 3DOK 3DOL 3DOX 3DRP 3DRR 3DRS 3DYA 3E01 3I0R 3I0S 3PHV
Structure:
3PHV

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: