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Drug-Target Interaction

Drug

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PubChem ID:5593
Structure:
Synonyms:
(+-)-N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide
1508-75-4
5-22-09-00359 (Beilstein Handbook Reference)
AB00052120
AC-816
AC1L1KOZ
AC1Q5IFA
AG-D-97626
AR-1K6980
BB_SC-4139
Benzeneacetamide, N-ethyl-.alpha.-(hydroxymethyl)-N-(4-pyridinylmethyl)-
Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-
Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-,
Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-, (+-)-
Bio-0810
Bistropamide
BPBio1_000303
BRD-A79672927-001-05-8
BRN 0285563
BSPBio_000275
BSPBio_002289
C17H20N2O2
CCG-40076
CHEMBL1200604
CPD000058523
D00397
DB00809
DivK1c_000448
EINECS 216-140-2
Epitromina
EU-0101223
HMS1568N17
HMS1921I09
HMS2089M05
HMS2092A18
HMS2095N17
HMS2235J15
HMS3259M18
HMS3263F08
HMS501G10
Hydracrylamide, N-ethyl-2-phenyl-N-(4-pyridylmethyl)-
I-Picamide
I06-0811
IDI1_000448
KBio1_000448
KBio2_001064
KBio2_003632
KBio2_006200
KBio3_001509
KBioGR_000873
KBioSS_001064
L001262
Lopac0_001223
LS-28545
Minims tropicamide
Mixture Name
MLS001306442
MLS002154240
Mydriacyl
Mydriacyl (TN)
MYDRIAFAIR
Mydriaticum
Mydrum
N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide
N-Ethyl-2-phenyl-N-4-[-pyridyl-methyl]hydracrylamide
N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide
N-Ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide
N-Ethyl-N-(4-pyridylmethyl)tropamid
N-Ethyl-N-(4-pyridylmethyl)tropamide
n-ethyl-n-(g-picolyl)tropamide
NCGC00016065-03
NCGC00016065-04
NCGC00016065-05
NCGC00016065-06
NCGC00016065-07
NCGC00016065-08
NCGC00016065-09
NCGC00024866-02
NCGC00024866-03
NCGC00024866-04
NCGC00024866-05
NCGC00024866-06
NINDS_000448
Ocu-Tropic
Opticyl
Paremyd
Prestwick0_000228
Prestwick1_000228
Prestwick2_000228
Prestwick3_000228
Prestwick_487
Ro 1-7683
SAM002564235
SMP1_000304
SMR000058523
SPBio_000872
SPBio_002196
Spectro-Cyl
SPECTRUM1500599
Spectrum2_000936
Spectrum3_000655
Spectrum4_000377
Spectrum5_001585
Spectrum_000584
STK934612
T 9778
T9778_SIGMA
TL8001101
TROPICACYL
Tropicamid
Tropicamida
Tropicamida [INN-Spanish]
TROPICAMIDE
Tropicamide (JP15/USP/INN)
Tropicamide (JP16/USP/INN)
Tropicamide [USAN:BAN:INN:JAN]
Tropicamide [USAN:INN:BANJAN]
Tropicamidum
Tropicamidum [INN-Latin]
Tropikamid
Tropimil
UNII-N0A3Z5XTC6
Visumidriatic
ATC-Codes:
Side-Effects:
Side-EffectFrequency
tachycardia0
nausea0
photophobia0
vomiting0
blurred vision0
shock0
headache0
keratitis0
allergic reaction0

Target

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Uniprot ID:ACM4_HUMAN
Synonyms:
Muscarinic acetylcholine receptor M4
EC-Numbers:-
Organism:Homo sapiens
Human
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----
----

References:

12961062
The cholinomimetic agent bethanechol activates IK(ACh) in feline atrial myocytes.. Dora E Benavides-Haro; Ricardo A Navarro-Polanco; José A Sánchez-Chapula (2003) Naunyn-Schmiedeberg's archives of pharmacology display abstract
The effect of the cholinomimetic agent, bethanechol on macroscopic membrane currents was studied in dispersed cat atrial myocytes, using the whole-cell patch-clamp technique. Bethanechol activated an inward rectifying potassium current similar to I(K(ACh)), and a delayed rectifying-like outward current, similar to I(KM3) activated by pilocarpine, choline, and tetramethylammonium, and I(KM4) activated by 4-aminopyridine. The relatively specific muscarinic receptors subtype antagonists methoctramine (M(2)), and tropicamide (M(4)) inhibited both current components induced by bethanechol, suggesting a lack of specificity of these antagonists on cat atrial myocytes. The specific antagonist of M(3) receptors, para-fluoro-hexahydro-siladifenidol did not significantly inhibit the bethanechol-induced currents. In addition, pretreatment with PTX prevented activation of the bethanechol-induced inward and outward currents, suggesting that M(3) receptors are probably not involved in the bethanechol action. The I(K(ACh)) specific blocker tertiapin inhibited both inward rectifying- and delayed rectifying-like currents. These results suggest that both current components result from activation of a single channel type, likely I(K(ACh)).
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