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Drug-Target Interaction

Drug

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PubChem ID:5578
Structure:
Synonyms:
"trimethoprim (8064-90-2 (trimethoprim/sulfamethoxazole); tmp/smx (mixture))"
2,4-Diamino-5-(3',4',5'-trimethoxybenzyl)pyrimidine
2,4-diamino-5-(3,4,5-trimethoxybenzyl) pyrimidine
2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
2,4-Diamino-5-(3,4,5-trimethoxyphenzyl)pyrimidine
2,4-Diamino-5-[3,4,5-trimethoxy-benzyl]pyrimidine
2,4-Pyrimidinediamine, 5-((3,4,5-trimethoxyphenyl)-methyl)-
2,4-Pyrimidinediamine, 5-((3,4,5-trimethoxyphenyl)methyl)-
2,4-Pyrimidinediamine, 5-[(3,4,5-trimethoxyphenyl)methyl]-
46984_FLUKA
46984_RIEDEL
5-((3,4,5-Trimethoxyphenyl)methyl)-2,4-pyrimidinediamine
5-(3,4,5-Trimethoxy-benzyl)-pyrimidine-2,4-diamine
5-(3,4,5-Trimethoxybenzyl)-2,4-diaminopyrimidine
5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine
5-25-13-00429 (Beilstein Handbook Reference)
5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine
5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
5-{[3,4,5-tris(methyloxy)phenyl]methyl}pyrimidine-2,4-diamine
738-70-5
8064-90-2
92131_FLUKA
92131_SIGMA
AB00052118
AB1004879
Abaprim
AC-13572
AC1L1KNQ
AC1Q48DF
Acuco
AI3-52594
AIDS-010922
AIDS-110808
AIDS010922
AIDS110808
AKOS001650069
Alcorim-F
Alprim
Anitrim
Antrima
Antrimox
Apo-Sulfatrim
ARONIS24118
AZT + TMP/SMX (mixture) combination
Bacdan
Bacidal
Bacide
Bacin
Bacta
Bacterial
Bacterial [Antibiotic]
Bacticel
Bactifor
Bactin
Bactoprim
Bactramin
Bactrim
Bactrim DS
BACTRIM PEDIATRIC
BB_SC-2116
Bencole
Bethaprim
BIDD:GT0190
Biosulten
BPBio1_000215
BRD-K07208025-001-06-5
Briscotrim
BRN 0625127
BSPBio_000195
BSPBio_002245
BW 56-72
BW 5672
BW-56-72
C01965
C14H18N4O3
CAS-738-70-5
CCG-40335
CCRIS 2410
Centrim
CHEBI:45924
CHEMBL22
Chemotrin
Cidal
Co-Trimoxizole
Colizole
Colizole DS
component of Bactrim
component of Septra
Conprim
Cotrim
COTRIM D.S
Cotrimel
CPD0-1581
CPD000035999
D00145
D014295
DB00440
Deprim
Diseptyl
DivK1c_000589
Dosulfin
DRG-0030
Duocide
EINECS 212-006-2
Esbesul
Espectrin
EU-0101271
Euctrim
Exbesul
Fermagex
Fortrim
Futin
HMS1568J17
HMS1921I03
HMS2090D14
HMS2092A10
HMS2095J17
HMS2230L06
HMS3259I11
HMS3263P04
HMS501N11
HSDB 6781
I06-0086
IDI1_000589
Idotrim
Ikaprim
Instalac
Ipral
KBio1_000589
KBio2_000647
KBio2_003215
KBio2_005783
KBio3_001465
KBioGR_000863
KBioSS_000647
Kombinax
KSC-4-158
KUC103659N
Lagatrim
Lagatrim Forte
Lastrim
Lescot
Lopac-T-7883
Lopac0_001271
LS-1627
Methoprim
Metoprim
Mixture Name
MLS000079023
MLS001201740
MLS002303068
Monoprim
Monotrim
Monotrimin
NCGC00016055-01
NCGC00016055-02
NCGC00016055-03
NCGC00016055-04
NCGC00016055-05
NCGC00016055-06
NCGC00016055-07
NCGC00016055-08
NCGC00016055-09
NCGC00016055-10
NCGC00016055-11
NCGC00016055-12
NCGC00016055-13
NCGC00016055-14
NCGC00024707-01
NCGC00024707-03
NCGC00024707-04
NCGC00024707-05
NCGC00024707-06
NCGC00024707-07
NCGC00024707-08
nchembio.108-comp1
nchembio.215-comp11
nchembio.221-comp23
NIH 204
NIH 204 (VAN)
NINDS_000589
Novotrimel
NSC 106568
NSC-106568
NSC106568
Omstat
Oprea1_495058
Oraprim
Pancidim
Polytrim
Prestwick0_000208
Prestwick1_000208
Prestwick2_000208
Prestwick3_000208
Prestwick_485
Priloprim
Primosept
Primsol
Proloprim
Proloprim (TN)
Protrin
Purbal
Pyrimidine, 2,4-diamino-5-(3,4,5-trimethoxybenzyl)-
Resprim
Resprim Forte
Roubac
Roubal
Salvatrim
SAM002264649
Septra
SEPTRA DS
SEPTRA GRAPE
Septrin DS
Septrin Forte
Septrin S
Setprin
Sinotrim
SMP2_000262
SMR000035999
Smz-Tmp
SMZ/TMP
SPBio_000874
SPBio_002116
SPECTRUM1500595
Spectrum2_000937
Spectrum3_000643
Spectrum4_000372
Spectrum5_001559
Spectrum_000167
ST024737
STK177322
Stopan
Streptoplus
Sugaprim
Sulfamar
Sulfamethoprim
SULFAMETHOPRIM-DS
SULFAMETHOXAZOLE & TRIMETHOPRIM
SULFAMETHOXAZOLE AND TRIMETHOPRIM
SULFAMETHOXAZOLE AND TRIMETHOPRIM AND PENAZOPYRIDINE HCL
SULFAMETHOXAZOLE AND TRIMETHOPRIM DOUBLE STRENGTH
SULFAMETHOXAZOLE AND TRIMETHOPRIM SINGLE STRENGTH
Sulfamethoxazole Trimethoprim
Sulfatrim
SULFATRIM PEDIATRIC
SULFATRIM-DS
SULFATRIM-SS
Sulfoxaprim
Sulmeprim
SULMEPRIM PEDIATRIC
Sulthrim
Sultrex
Syraprim
T 7883
T2286
T7883_SIGMA
TCMDC-125538
Tiempe
TL8005108
TMP
Tmp Smx
Tmp-Ratiopharm
TMP/SMX
Tocris-0650
TOP
Toprim
Trimanyl
Trimeth/Sulfa
Trimethioprim
Trimethopim(TMP)
Trimethoprim
Trimethoprim & VRC3375
TRIMETHOPRIM (8064-90-2 (TRIMETHOPRIM/SULFAMETHOXAZOLE)
TRIMETHOPRIM (8064-90-2 (TRIMETHOPRIM/SULFAMETHOXAZOLE); TMP/SMX (MIXTURE))
Trimethoprim (JAN/USP/INN)
TRIMETHOPRIM SULFATE AND POLYMYXIN B SULFATE
Trimethoprim [USAN:BAN:INN:JAN]
Trimethoprim/sulfamethoxazole (commercial)
Trimethoprime
Trimethoprime [INN-French]
Trimethoprimum
Trimethoprimum [INN-Latin]
Trimethopriom
Trimetoprim
Trimetoprim [DCIT]
Trimetoprim [Polish]
Trimetoprima
Trimetoprima [INN-Spanish]
Trimexazole
Trimexol
Trimez-IFSA
Trimezol
Trimogal
Trimono
Trimopan
Trimpex
Trimpex (TN)
TRIMPEX 200
Triprim
Trisul
Trisulcom
Trisulfam
Trisural
U-Prin
UNII-AN164J8Y0X
UPCMLD-DP132
UPCMLD-DP132:001
Uretrim
Uro-D S
Urobactrim
UROPLUS DS
UROPLUS SS
Utetrin
Velaten
Veltrim
Wellcoprim
Wellcoprin
WLN: T6N CNJ BZ DZ E1R CO1 DO1 EO1
WR 5949
Xeroprim
Zamboprim
ZINC06627681
ATC-Codes:
Side-Effects:
Side-EffectFrequency
methemoglobinemia0
anemia0
exfoliative dermatitis0
vomiting0
hyperkalemia0
anaphylaxis0
nausea0
hyponatremia0
glossitis0
megaloblastic anemia0
pruritus0
neutropenia0
stevens - johnson syndrome0
erythema0
rash0
erythema multiforme0
jaundice0
toxic epidermal necrolysis0
fever0
aseptic meningitis0
hypersensitivity0
thrombocytopenia0
leukopenia0

Target

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Uniprot ID:DRTS_PLABA
Synonyms:
Bifunctional dihydrofolate reductase-thymidylate synthase
DHFR-TS
EC-Numbers:-
Organism:Plasmodium berghei
strain Anka
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: