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Drug-Target Interaction

Drug

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PubChem ID:5564
Structure:
Synonyms:
"triclosan; irgasan"
112099-35-1
164325-69-3
2,4,4'-Trichloro-2'-hydroxy diphenyl ether
2,4,4'-Trichloro-2'-hydroxydiphenyl ether
2-Hydroxy-2',4,4'-trichlorodiphenyl Ether
261921-78-2
3380-34-5
5-Chloro-2-(2,4-dichloro-phenoxy)-phenol
5-CHLORO-2-(2,4-DICHLOROPHENOXY)PHENOL
524190_ALDRICH
72779_FLUKA
72779_SIGMA
88032-08-0
AC-10667
AC1L1KMN
AIDS-095068
AIDS095068
Aquasept
BRN 2057142
C12059
C12H7Cl3O2
Caswell No. 186A
CCRIS 9253
CH 3565
CH-3565
CHEBI:164200
CHEMBL849
Clearasil Daily Face Wash
Cliniclean
Cloxifenol
Cloxifenolum
COLGATE TOTAL
CPD0-1227
CPD000471847
D014260
D06226
DB08604
Dermtek Brand of Triclosan
DP-300
EINECS 222-182-2
EPA Pesticide Chemical Code 054901
Ether, 2'-hydroxy-2,4,4'-trichlorodiphenyl
GlaxoSmithKline Brand of Triclosan
HMS2093L17
HMS2270M06
HMS3259K19
HSDB 7194
I01-2897
IN1424
Irgasan
Irgasan DP 300
Irgasan DP300
Johnson & Johnson Brand of Triclosan
Lexol 300
LS-67854
Manusept
Microshield T
MLS001066347
MLS001074876
MLS001335937
MLS001335938
MolPort-003-666-702
NCGC00159417-02
NCGC00159417-03
NCGC00159417-04
NCGC00159417-05
NCGC00159417-06
NCGC00159417-07
Oxy Skin Wash
Pharmachem Brand of Triclosan
Phenol, 5-chloro-2-(2,4-dichlorophenoxy)-
Phenyl ether, 2'-hydroxy-2,4,4'-trichloro-
pHisoHex
Procter & Gamble Brand of Triclosan
Reckitt Brand of Triclosan
S00100
SAM002554907
Sapoderm
SBB058565
SMR000471847
SSL Brand of Triclosan
Ster Zac Bath Concentrate
Ster-Zac Bath Concentrate
SterZac Bath Concentrate
Stri-Dex Cleansing Bar
Stri-Dex cleansing bar (TN)
Stri-Dex Face Wash
TCL
Tersaseptic
TL8002539
Trans Canaderm Brand of Triclosan
Triclosan
Triclosan (USP/INN)
Triclosan Pharmachem Brand
Triclosan Reckitt Brand
Triclosan [USAN:BAN:INN]
Triclosan; Irgasan
Triclosanum
Triclosanum [INN-Latin]
Trisan
UNII-4NM5039Y5X
ZINC00002216
ATC-Codes:

Target

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Uniprot ID:CP1A1_HUMAN
Synonyms:
CYPIA1
Cytochrome P450 1A1
P450 form 6
P450-C
P450-P1
EC-Numbers:1.14.14.1
Organism:Homo sapiens
Human
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

8696774
Interaction of 2,4,4'-trichloro-2'-hydroxydiphenyl ether with microsomal cytochrome P450-dependent monooxygenases in rat liver.. N Hanioka; E Omae; T Nishimura; H Jinno; S Onodera; R Yoda; M Ando (1996) Chemosphere display abstract
We studied the effects of 2,4,4'-trichloro-2'-hydroxydiphenyl ether (Irgasan DP300) on the kinetics of the cytochrome P450 (P450)-dependent monooxygenases in rat liver microsomes. The activities of 7-ethoxyresorufin O-deethylase (EROD) and 7-pentoxyresorufin O-depentylase (PROD) in rat liver microsomes exposed to 3-methylcholanthrene (MC) and phenobarbital (PB) respectively, were substantially inhibited by Irgasan DP300. The inhibition profile of EROD was competitive, whereas that of PROD was noncompetitive; the Ki values from Hanes plots were 0.24 and 1.48 microM for EROD and PROD, respectively. Phenacetin O-deethylase (PCOD) and 4-nitrophenol hydroxylase (4NPH) activities in rats exposed to PB were also inhibited by Irgasan DP300, at Ki values lower than those for other microsomes. Irgasan DP300 slightly inhibited testosterone 6 beta-hydroxylase (TS6BH) activities in some microsomes. No effect of Irgasan DP300 on lauric acid omega-hydroxylase (LAOH) activity was evident in any microsomal preparations. These results indicated that Irgasan DP300 inhibits MC- and PB-inducible P450-dependent monoxygenase in vitro competitively or noncompetitively, and that the P450 enzymes of the CYP1A or CYP2B subfamily may contribute to Irgasan DP300 toxicity.