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Drug-Target Interaction

Drug

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PubChem ID:5472495
Structure:
Synonyms:
(Z)-5-Fluoro-2-methyl-1[p-(methylsulfonyl)benzylidene]indene-3-acetic Acid
1H-Indene-3-acetic acid, 5-fluoro-2-methy
1H-Indene-3-acetic acid, 5-fluoro-2-methy l-1-((4-(methylsulfonyl)phenyl)methylene)-
1H-Indene-3-acetic acid, 5-fluoro-2-methy l-1-((4-(methylsulfonyl)phenyl)methylene)-, (Z)-
1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfonyl)phenyl)methylene)-, (1Z)-
5-Fluoro-2-methy l-1-((4-(methylsulfonyl)phenyl)methylene)-1H-indene-3-acetic acid
5-Fluoro-2-methyl-1-((Z)-p-(methylsulfonyl)benzylidene)indene-3-acetic acid
59864-04-9
59973-80-7
Aptosyn
C20H17FO4S
CCRIS 7242
cis-5-Fluoro-2-methyl-1-(p-methylsulfonylbenzylidenyl)indene-3-acetic acid
CP 248
CP248
Curator_000028
EU-0101115
Exisulind
FGN 1
FGN-1
Lopac-S-1438
Lopac0_001115
LS-176044
LS-176053
NCGC00015928-01
NCGC00094385-01
NCGC00162346-01
NSC719619
Prevatec
Sulindac sulfone
sulindac sulfone, (Z)-isomer
[(1Z)-5-fluoro-2-methyl-1-{[4-(methylsulfonyl)phenyl]methylidene}-1H-inden-3-yl]acetic acid

Target

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Uniprot ID:ICE_DROME
Synonyms:
Caspase
drICE
EC-Numbers:3.4.22.-
Organism:Drosophila melanogaster
Fruit fly
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References:

12017300
Sulindac induces apoptosis, inhibits proliferation and activates caspase-3 in Hep G2 cells.. Jian-Jun Liu; Ji-Yao Wang; Erik Hertervig; Ake Nilsson; Rui-Dong Duan (2002) Anticancer research display abstract
BACKGROUND: It has recently been reported that sulindac has an apoptotic effect on KYN-2 cells, an undifferentiated hepatoma cell line. The present work investigates whether sulindac also has an apoptotic effect on well-differentiated hepatoma cells and what its potential mechanism might be. MATERIALS AND METHODS: Hep G2 cells were treated with sulindac at different concentrations. Apoptosis rate, cell proliferation and 3H-thymidine incorporation were measured. The activities of caspase-3, acid and neutral sphingomyelinase and the changes of sphingomyelin content were also assayed. RESULTS: Sulindac dose-dependently induced apoptosis in Hep G2 cells; both sulindac sulfone and sulfide had similar effects. The apoptosis was accompanied by an increase of caspase-3 activity and a decrease of cell proliferation and 3H-thymidine incorporation. No significant change could be observed for the activity of sphingomyelinase and sphingomyelin content. CONCLUSION: Sulindac induces apoptosis and inhibits proliferation in Hep G2 cells. The effect may be mediated by a pathway related to caspase-3 activation but independent of sphingomyelin metabolism