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Drug-Target Interaction

Drug

show drug details
PubChem ID:5430
Structure:
Synonyms:
123242-33-1
145316-67-2
148-79-8
1H-Benzimidazole, 2-(4-thiazolyl)-
1yvm
2-(1,3-thiazol-4-yl)-1H-1,3-benzodiazole
2-(1,3-THIAZOL-4-YL)-1H-BENZIMIDAZOLE
2-(1,3-Thiazol-4-yl)benzimidazole
2-(4'-Thiazolyl)benzimidazole
2-(4-Thiazolyl)-1H-benzimidazole
2-(4-Thiazolyl)benzimidazole
2-(Thiazol-4-yl)benzimidazole
2-Thiazol-4-yl-1H-benzoimidazole
2-Thiazole-4-ylbenzimidazole
2-[4-Thiazoly]benzimidazole
4-(1H-benzimidazol-2-yl)-1,3-thiazole
4-(2-Benzimidazolyl)thiazole
4-benzimidazol-2-yl-1,3-thiazole
45684_FLUKA
45684_RIEDEL
8018-04-0
8027-10-9
8028-27-1
94977-06-7
98002-42-7
A0920/0043056
AB00052107
AC1L1KCB
AC1Q4W1V
AI3-50598
AIDS-007903
AIDS007903
AKOS000120940
APL-luster
BAS 00600238
Benzimidazole, 2-(4-thiazolyl)-
BIDD:ER0372
Bio-0781
Biogard
Bioguard
Bovizole
BPBio1_000559
BRD-K77695569-001-05-2
BRN 0611403
BSPBio_000507
BSPBio_003054
C07131
C10H7N3S
Captan T
CAS-148-79-8
Caswell No. 849A
CCG-39633
CCRIS 4510
CHEBI:45979
CHEMBL625
Chemviron TK 100
CPD000058170
Cropasal
D00372
D013827
DB00730
DB08630
DivK1c_000072
Drawipas
E-Z-Ex
EINECS 205-725-8
EPA Pesticide Chemical Code 060101
Eprofil
Equivet TZ
Equizole
Equizole A
G 491
Helmindrax octelmin
HMS1569J09
HMS1921E05
HMS2092M07
HMS2096J09
HMS2230F20
HMS3259E20
HMS500D14
Hokustar HP
HSDB 2027
Hymush
I06-0809
IDI1_000072
KBio1_000072
KBio2_000399
KBio2_002967
KBio2_005535
KBio3_002274
KBioGR_000787
KBioSS_000399
Lombristop
LS-864
Mertec
Mertect
Mertect 160
Mertect 340f
Mertect lsp
Metasol tk 10
Metasol TK 100
Metasol TK-100
Mintesol
Mintezol
Mintezol (TN)
Mintezol, Equizole, Thiabendazole
Mintezole
Minzolum
Mixture Name
MK 360
MK-360
MLS-0002984.P004
MLS000053094
MLS000069718
Mycozol
NCGC00016410-01
NCGC00016410-02
NCGC00016410-03
NCGC00016410-04
NCGC00016410-05
NCGC00016410-06
NCGC00016410-07
NCGC00016410-08
NCGC00016410-09
NCGC00016410-10
NCGC00016410-11
NCGC00016410-12
NCGC00016410-13
NCGC00016410-14
NCGC00016410-15
NCGC00021671-04
NCGC00021671-05
NCGC00021671-06
NCGC00021671-07
NCGC00021671-08
NCGC00021671-09
NCGC00021671-10
NCI60_004280
NCI60_042006
NCIOpen2_005709
Nemacin
Nemapan
NINDS_000072
NSC 525040
NSC 90507
NSC525040
NSC90507
Omnizole
Ormogal
Pitrizet
Polival
Prestwick0_000524
Prestwick1_000524
Prestwick2_000524
Prestwick3_000524
Prestwick_813
PS1057_SUPELCO
Rival
RPH
RTU Flowable Fungicide
S1739_Selleck
SAM002564239
Sanaizol 100
SDCCGMLS-0002984.P003
Sistesan
SMR000058170
SPBio_001481
SPBio_002428
SPECTRUM1500570
Spectrum2_001331
Spectrum3_001407
Spectrum4_000354
Spectrum5_001009
Spectrum_000039
ST023311
STK394289
Storite
Syntol M100
T5535_SIGMA
T8904_SIGMA
Tbdz
TBZ
TBZ 6
TBZ 60W
TBZ-6
Tebuzate
Tecto
Tecto 10P
Tecto 40F
Tecto 60
Tecto B
Tecto RPH
Testo
Thiaben
Thiabendazol
THIABENDAZOLE
Thiabendazole (USP)
Thiabendazole [BSI:ISO]
Thiabendazole [USAN:BAN]
Thiabendazole-Supplied by Selleck Chemicals
Thiabendazolum
Thiabendole
Thiabenzazole
Thiabenzole
Thibendole
Thibenzol
Thibenzole
Thibenzole 200
Thibenzole ATT
Thiprazole
Tiabenda
Tiabendazol
Tiabendazol [INN-Spanish, French]
Tiabendazole
Tiabendazole (JAN/INN)
Tiabendazolo
Tiabendazolum
Tiabendazolum [INN-Latin]
Tibimix 20
TL8001064
TMG
Tobaz
Top form wormer
Tresaderm
Triasox
Tubazole
UNII-N1Q45E87DT
WLN: T56 BM DNJ C-ET5N CSJ
ZINC00073711
ATC-Codes:
Side-Effects:
Side-EffectFrequency
lymphadenopathy0
hypotension0
convulsions0
diarrhea0
tinnitus0
vomiting0
hepatic failure0
pain0
giddiness0
somnolence0
anaphylaxis0
nausea0
anorexia0
shock0
flushing0
leukopenia0
headache0
enuresis0
fatigue0
erythema multiforme0
jaundice0
angioedema0
numbness0
hematuria0
blurred vision0
chills0
stevens - johnson syndrome0
hypersensitivity0
confusion0
hyperglycemia0
dizziness0
pruritus0
abdominal pain0
abnormal vision0
weakness0
giddiness0

Target

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Uniprot ID:CP1A1_HUMAN
Synonyms:
CYPIA1
Cytochrome P450 1A1
P450 form 6
P450-C
P450-P1
EC-Numbers:1.14.14.1
Organism:Homo sapiens
Human
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----
----
----
----
----
----
----

References:

10445394
7565906
7872687
8078896
8900397
9616189
9784250
Induction of cytochrome P-450 1A1 by omeprazole in human HepG2 cells is protein tyrosine kinase-dependent and is not inhibited by alpha-naphthoflavone.. H Kikuchi; A Hossain; H Yoshida; S Kobayashi (1998) Archives of biochemistry and biophysics display abstract
Benzimidazole compounds, such as omeprazole and thiabendazole, are a different type of CYP1A1 inducer from Ah receptor-ligands, such as TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) and 3-methylcholanthrene. In HepG2 cells, the commonly used tyrosine kinase inhibitors, herbimycin-A and a series of tyrphostins, inhibited the induction of CYP1A1 produced by treatment with TCDD. Genistein, another type of tyrosine kinase inhibitor, inhibited the induction of CYP1A1 whether it was produced by omeprazole or TCDD; however, this inhibition was caused by a dual effect of genistein, that is an anti-tyrosine kinase and an anti-topoisomerase I effect. An antagonist of Ah receptor, alpha-naphthoflavone (0.1-10 microM), and 3'-methoxy-4'-aminoflavone (1 microM), did not inhibit the induction of CYP1A1 produced in HepG2 cells by omeprazole, but both of them did inhibit that produced by TCDD. In one of a number of human lung tumor cell lines, S6T, the inducibility of CYP1A1 was high by TCDD, whereas the inducibility by omeprazole was low. Thus, omeprazole appears to induce CYP1A1 by initiating a protein tyrosine kinase-mediated signal transduction pathway, a different pathway from that inhibited by TCDD.