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Drug-Target Interaction

Drug

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PubChem ID:5411
Structure:
Synonyms:
136-47-0
136-47-0 (mono-hydrochloride)
2-(dimethylamino)ethyl 4-(butylamino)benzoate
2-(Dimethylamino)ethyl p-(butylamino)benzoate
2-dimethylaminoethyl 4-(butylamino)benzoate
2-Dimethylaminoethylester kyseliny p-butylaminobenzoove
2-Dimethylaminoethylester kyseliny p-butylaminobenzoove [Czech]
4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester
4-14-00-01172 (Beilstein Handbook Reference)
4-[Butylamino]benzoic acid-2-[dimethylamino]ethyl ester
94-24-6
AB00053549
AC-3480
AC1L1KAQ
Amethocaine
Amethocaine (TN)
Anetain
Benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester
BENZOIC ACID, p-(BUTYLAMINO)-, 2-(DIMETHYLAMINO)ETHYL ESTER
BENZOIC ACID,4-BUTYLAMINO,2-DIMETHYLAMINOETHYL ESTER PANTOCAIN BASE
BENZOIC ACID,4-BUTYLAMINO,2-DIMETHYLAMINOETHYL ESTER PANTOCAIN BASE
BPBio1_000422
BRD-K45071273-003-05-8
BRN 2216051
BSPBio_000382
BSPBio_001944
C07526
C15H24N2O2
CAS-136-47-0
CCG-205285
CHEBI:9468
CHEMBL698
Contralgin
D00551
Diaethylaminoaethanol ester der p-butylaminobenzoesaeure
Diaethylaminoaethanol ester der p-butylaminobenzoesaeure [German]
Dicain
Dicaine
Dikain
Dimethylaminoethyl p-butyl-aminobenzoate
DivK1c_000607
EINECS 202-316-6
Fissucain
I01-1872
IDI1_000607
Intercain
KBio1_000607
KBio2_001512
KBio2_004080
KBio2_006648
KBio3_001444
KBioGR_000781
KBioSS_001512
Laudocaine
Lopac-T-7508
Lopac0_001211
LS-36312
Medicaine
Medihaler-Tetracaine
Meethobalm
Metraspray
Mucaesthin
NCGC00016049-01
NCGC00016049-02
NCGC00016049-03
NCGC00016049-04
NCGC00162367-01
NINDS_000607
Niphanoid
p-(Butylamino)benzoic acid, 2-(dimethylamino)ethyl ester
p-Butylaminobenzoyl-2-dimethylaminoethanol
Pontocaine
Prestwick0_000571
Prestwick1_000571
Prestwick2_000571
Prestwick3_000571
Rexocaine
SBB058194
SPBio_001455
SPBio_002601
Spectrum2_001328
Spectrum3_000562
Spectrum4_000351
Spectrum5_001072
Spectrum_001032
T3812_SIAL
T7383_SIAL
T7383_SIGMA
Tetracaina
Tetracaina [INN-Spanish]
Tetracaine
Tetracaine (USP/INN)
Tetracaine hydrochloride
Tetracaine [USAN:INN]
Tetracainum
Tetracainum [INN-Latin]
Tetrakain
Tetrakain [Czech]
UNII-0619F35CGV
Uromucaesthin
ATC-Codes:

Target

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Uniprot ID:PA2GA_CAVPO
Synonyms:
GIIC sPLA2
Group IIA phospholipase A2
Phosphatidylcholine 2-acylhydrolase
Phospholipase A2, membrane associated
EC-Numbers:3.1.1.4
Organism:Cavia porcellus
Guinea pig
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

6653661
Inhibition of agonist-induced degradation of muscarinic cholinergic receptor by quinacrine and tetracaine--possible involvement of phospholipase A2 in receptor degradation.. H Higuchi; S Uchida; K Matsumoto; H Yoshida (1983) European journal of pharmacology display abstract
Muscarinic cholinergic receptors (mAChR) are degraded on the addition of agonists through energy- and temperature-dependent processes, probably with clustering and endocytosis. Pretreatment of guinea-pig vas deferens with 0.5 mM quinacrine or 5 mM tetracaine, phospholipase A2 (PLase A2) inhibitors, inhibited the ACh-induced degradation of mAChR in the smooth muscle and kept mAChR on the surface membrane, while cocaine and procaine were not effective. On pretreatment with quinacrine or tetracaine the PLase A2 activity in the smooth muscle decreased continuously during culture without change in the contractile response of the tissue. Pretreatment with cocaine and procaine which had no significant effect on the down regulation of mAChR did not inhibit PLase A2 activity. However, activation of PLase A2 by long-term culture of the muscle with ACh and formation of endogenous inhibitor of PLase A2 were not observed under our experimental conditions. The participation of PLase A2 in the agonist-induced degradation of mAChR is discussed in the light of these findings.