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Drug-Target Interaction

Drug

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PubChem ID:5329102
Structure:
Synonyms:
1H-Pyrrole-3-carboxamide,
1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-
1H-Pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[(Z)- (5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-
326914-13-0
557795-19-4
CHEBI:38940
DB01268
K00588a
LS-187023
LS-187648
N-(2-diethylaminoethyl)-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
NCGC00164631-01
NSC736511
PDGF TK antagonist
STOCK6S-48542
SU 11248
Su-011248
SU-11248
SU-11248J
SU-12662
SU11248
Sunitanib
Sunitinib
Sunitinib malate
Sutent
ATC-Codes:
Side-Effects:
Side-EffectFrequency
thrombotic microangiopathy0.0010
proteinuria0.0010
nephrotic syndrome0.0010
seizures0
stomatitis0
cerebrovascular accident0
thrombocytopenia0
thyroiditis0
thyrotoxicosis0
erythema0
vascular disorders0
rhabdomyolysis0
lymphopenia0
mediastinal disorders0
nausea0
neutropenia0
pain0
pain in limb0
pancreatitis0
peripheral neuropathy0
pulmonary embolism0
abnormal vision0
vomiting0
weight loss0
hypopigmentation0
oral pain0
myalgia0
abdominal pain upper0
depressed mood0
bradycardia0
blindness0
lung cancer0
hyperuricemia0
deep thrombophlebitis0
dry skin0
dry mouth0
chills0
hepatic failure0
peripheral edema0
hypophosphatemia0
deep vein thrombosis0
amylase increased0
myocardial ischemia0
alkaline phosphatase increased0
insomnia0
leukopenia0
abdominal pain0
constitutional symptoms0
cough0
dehydration0
diarrhea0
dizziness0
dyspepsia0
dyspnea0
edema0
epistaxis0
constipation0
connective tissue disorders0
adrenal insufficiency0
alopecia0
anemia0
anorexia0
arrhythmia0
arthralgia0
asthenia0
back pain0
blistering0
reflux esophagitis0
rash0
fatigue0
hyperkalemia0
hypernatremia0
hypertension0
hypocalcemia0
hypoglycemia0
hypokalemia0
hyponatremia0
hypothyroidism0
infection0
hyperglycemia0
hypercalcemia0
fever0
flank pain0
flatulence0
gastroesophageal reflux0
glossodynia0
headache0
congestive heart failure0
hemoptysis0
hemorrhage0
jaundice0

Target

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Uniprot ID:MET_HUMAN
Synonyms:
c-Met
Hepatocyte growth factor receptor
HGF receptor
HGF/SF receptor
Met proto-oncogene tyrosine kinase
Scatter factor receptor
SF receptor
EC-Numbers:2.7.10.1
Organism:Homo sapiens
Human
PDB IDs:1FYR 1R0P 1R1W 1SHY 1SSL 1UX3 2G15 2RFN 2RFS 2UZX 2UZY 2WD1 2WGJ 3BUX 3CE3 3CTH 3CTJ 3EFJ 3EFK 3F66 3F82
Structure:
3F82

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
-->5E3-
->10000--
-->5000-

References: