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Drug-Target Interaction

Drug

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PubChem ID:5327
Structure:
Synonyms:
(p-Aminobenzolsulfonyl)-2-amino-4,6-dimethylpyrimidin
(p-Aminobenzolsulfonyl)-2-amino-4,6-dimethylpyrimidin [German]
00189_FLUKA
2-(4-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine
2-(p-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine
2-Sulfanilamido-4,6-dimethylpyrimidine
4,6-Dimethyl-2-sulfanilamidopyrimidine
4,6-Dimethylsulfadiazine
4-Amino-N- [4,6-dimethyl-2-pyrimidinyl]- benzenesulfonamide
4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide
4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide
4-Amino-N-(4,6-dimethyl-2-pyrimidyl)benzenesulfonamide
4-Amino-N-(4,6-dimethyl-pyrimidin-2-yl)-benzenesulfonamide
4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzene-1-sulfonamide
4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
46802_FLUKA
46802_RIEDEL
5-25-10-00250 (Beilstein Handbook Reference)
57-68-1
57-68-1 (NEUTRAL)
6-(4'-Aminobenzol-sulfonamido)-2,4-dimethylpyrimidin
6-(4'-Aminobenzol-sulfonamido)-2,4-dimethylpyrimidin [German]
A-502
AC-16126
AC1L1K3W
AC1Q2ID9
AI3-26817
AIDS-027749
AIDS027749
AKOS000119894
ARONIS018080
ASWVTGNCAZCNNR-UHFFFAOYSA-
Azolmetazin
Benzenesulfonamide, 4-amino-N-(2,6-dimethyl-4-pyrimidinyl)-
Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-
BIDD:PXR0093
Bio-0716
BN 2409
BPBio1_000936
BRD-K11640013-001-02-6
BRD-K11640013-236-03-6
BRN 0261304
BSPBio_000850
BSPBio_003260
C12H14N4O2S
C19530
Calfspan Tablets
CBDivE_012932
CCG-39259
CCRIS 3701
CHEBI:102265
CHEMBL446
Cremomethazine
D013418
D02436
DB01582
Diazil
Diazil (the sulfanilamide)
Diazyl
Diazyl (VAN)
Dimezathine
Dimidin-R
DivK1c_000293
EINECS 200-346-4
Hava-Span
HC210279
HMS1921A17
HMS2092I19
HMS500O15
HSDB 4157
IDI1_000293
Intradine
KBio1_000293
KBio2_001470
KBio2_004038
KBio2_006606
KBio3_002480
KBioGR_000747
KBioSS_001470
Kelametazine
L-30
LS-232
Mefenal
Mermeth
Metazin
MLS000069711
MLS000103403
MLS001077331
MLS002454449
N(1)-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide
N(1)-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
N(1)-(4.6-Dimethyl-2-pyrimidinyl)sulfanilamide
N(sup 1)-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide
N(sup 1)-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
n(sup1)-(2,6-Dimethylpyrimid-4-yl)sulfanilamide
N(sup1)-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide
N(sup1)-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
N-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
NCGC00018243-01
NCGC00018243-02
NCGC00018243-03
NCGC00018243-04
NCGC00018243-05
NCGC00018243-06
NCGC00018243-07
NCGC00018243-08
NCGC00021490-03
NCGC00021490-04
NCGC00021490-05
NCGC00021490-06
NCI-C56600
NCIOpen2_003489
Neasina
Neazina
NINDS_000293
NSC 67457
NSC67457
NSC67457 (NEUTRAL)
NSC683529
NSC683529 (NEUTRAL)
Oprea1_142608
Oprea1_677935
Pirmazin
Prestwick0_000775
Prestwick1_000775
Prestwick2_000775
Prestwick3_000775
Primazin
S0586
S6256_SIGMA
Sa III
SMR000017409
Solfadimidina
Solfadimidina [DCIT]
Spanbolet
SPBio_001441
SPBio_002789
SPECTRUM1500548
Spectrum2_001321
Spectrum3_001700
Spectrum4_000344
Spectrum5_001270
Spectrum_000990
ST011913
STK097514
Sulfa-Isodimerazine
Sulfadimerazine
Sulfadimesin
Sulfadimesine
Sulfadimethyldiazine
Sulfadimethylpyrimidine
Sulfadimetine
Sulfadimezin
Sulfadimezine
Sulfadimezinum
Sulfadimidin
Sulfadimidina
Sulfadimidina [INN-Spanish]
Sulfadimidine
Sulfadimidine (INN)
Sulfadimidine solution
Sulfadimidine [INN:BAN]
Sulfadimidinum
Sulfadimidinum [INN-Latin]
Sulfadine
Sulfaisodimidine
Sulfametazina
Sulfametazina [Italian]
Sulfametazyny
Sulfametazyny [Polish]
Sulfamethazine
Sulfamethazine (USP)
Sulfamethazine solution
Sulfamethiazine
Sulfamethin
Sulfamezathine
Sulfamezathine (TN)
Sulfanilamide, N(1)-(4,6-dimethyl-2-pyrimidinyl)-
Sulfanilamide, N(sup 1)-(4,6-dimethyl-2-pyrimidinyl)-
Sulfanilamide, n(sup1)-(2,6-dimethyl-4-pyrimidinyl)-
Sulfanilamide, n(sup1)-(4,6-dimethyl-2-pyrimidinyl)-
Sulfanilamide, N1-(4,6-dimethyl-2-pyrimidinyl)-
SulfaSURE SR Bolus
Sulfisomidin
Sulfisomidine
Sulfodimesin
Sulfodimezine
Sulka S Boluses
Sulmet
Sulphadimethylpyrimidine
Sulphadimidine
Sulphamethasine
Sulphamethazine
Sulphamezathine
Sulphamidine
Sulphodimezine
Superseptil
Superseptyl
Triple Sulfa
UNII-48U51W007F
Vertolan
WLN: T6N CNJ BMSWR DZ& D1 F1
ZINC00057494
[(4-Aminophenyl)sulfonyl](4,6-dimethylpyrimidin-2-yl)amine
ATC-Codes:

Target

show target details
Uniprot ID:CP2C9_HUMAN
Synonyms:
(R)-limonene 6-monooxygenase
(S)-limonene 6-monooxygenase
(S)-limonene 7-monooxygenase
CYPIIC9
Cytochrome P450 2C9
P-450MP
P450 MP-4/MP-8
P450 PB-1
S-mephenytoin 4-hydroxylase
EC-Numbers:1.14.13.48
1.14.13.49
1.14.13.80
Organism:Homo sapiens
Human
PDB IDs:1OG2 1OG5 1R9O
Structure:
1R9O

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

9293615
Differential inhibitory effects of phenytoin, diclofenac, phenylbutazone and a series of sulfonamides on hepatic cytochrome P4502C activity in vitro, and correlation with some molecular descriptors in the dwarf goat (Caprus hircus aegagrus).. W M Zweers-Zeilmaker; G J Horbach; R F Witkamp (1997) Xenobiotica; the fate of foreign compounds in biological systems display abstract
1. The aim of the present study was to investigate the potency of various sulfonamides to inhibit tolbutamide hydroxylation (a CYP2C activity) in hepatic microsomal fractions and hepatocytes of the dwarf goat. Also a number of suggested substrates for human CYP2C9 was investigated. 2. From Dixon plots (microsomal fractions) it was observed that all compounds were competitive inhibitors of tolbutamide hydroxylation. Phenytoin (PT) showed the lowest Ki. Ki for the sulfonamides ranged between 205 and 4546 microM, sulfadoxine having the lowest Ki followed by sulfadimethoxine, sulfamoxole, sulfadimidine and sulfaphenazole. 3. In hepatocytes sulfaphenazole and diclofenac were the most potent inhibitors. 4. Out data indicate that PT, diclofenac (DF) and phenylbutazone (PBZ) are relative strong competitive inhibitors of tolbutamide hydroxylation and they are probably also substrates for the same enzyme. Differential inhibition of tolbutamide hydroxylation by sulfonamides was observed. 5. Correlation of structural parameters with the inhibition constant or the inhibition in hepatocytes showed that molecular volume, polarizability and molecular surface area are important parameters in determining the rate of inhibition of tolbutamide hydroxylation by sulfonamides in both microsomes and hepatocytes. In addition, log Poct are also involved in determining inhibition constants in microsomal fractions.