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Drug-Target Interaction

Drug

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PubChem ID:5317221
Structure:
Synonyms:
(13S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenan
AC1NSV90
beta-Estradiol
BRD-A18917088-001-02-3
BSPBio_001980
CCG-38366
DivK1c_000238
ESTRADIOL
HMS1920M06
HMS2091D07
HMS500L20
IDI1_000238
KBio1_000238
KBio2_001528
KBio2_004096
KBio2_006664
KBio3_001200
KBioGR_002489
KBioSS_001528
NCGC00178881-01
NINDS_000238
SPBio_000245
SPECTRUM1500282
Spectrum2_000063
Spectrum3_000420
Spectrum4_001822
Spectrum5_000583
Spectrum_001048
ATC-Codes:
Side-Effects:
Side-EffectFrequency
nasopharyngitis0.136777
headache0.13495435
breast tenderness0.10063571
back pain0.089925595
sinusitis nos0.08926434
upper respiratory tract infection nos0.07818359
moniliasis0.062
breast pain0.059999995
sinus headache0.057972737
influenza0.05737534
pain in limb0.055968452
dyspepsia0.054536853
infection0.05333333
abdominal pain0.05333333
urinary tract infection0.044999998
constipation0.04268522
insomnia0.041137606
sinus congestion0.039513495
neck pain0.03923876
weight increased0.03439724
arthralgia0.033610158
anxiety0.03189286
arthritis0.03
skeletal pain0.03
flatulence0.0275
rhinitis0.025999999
allergy0.024999999
pharyngitis0.024166666
nausea0.023452189
flushes0.023422109
pain nos0.022763988
hypertension nos0.015158984
intermenstrual bleeding0.014541405
edema0.008794118
dysmenorrhea0.006373744
pruritis0.0054137935
vaginal bleeding0.002647059
vaginitis0.0023666667
micturition frequency0.0010
weight decrease0.0010
arthropathy0.0010
swelling0.0010
elevated liver function tests0.0010
allergic reaction0.0010
disorder vascular0.0010
leg pain0.0010
abnormal vision0.0010
breast enlargement0.0010
decreased libido0.0010
pruritus ani0.0010
uterine bleeding0.00025
glucose intolerance0.00025
pelvic pain0.00025
anaphylaxis0.00019
urticaria0.00009
rash0.00008
thrombophlebitis0.00008
nervousness0.00008
vomiting0.00008
dizziness0.00008
dementia0.00005
erythema multiforme0.00005
hemangiomas0.00005
bloating0.00005
hirsutism0.00004
jaundice0.00004
pancreatitis0.00004
chloasma0.00004
pulmonary embolism0.00004
gall bladder disease0.00004
nipple discharge0.00004
mental depression0.00004
venous thrombosis0.00004
galactorrhea0.00004
abdominal cramps0.00004
migraine0.00004
epilepsy0.00004
erythema nodosum0.00004
increase in blood pressure0.00004
angioedema0.00004
fibrocystic breast0.00004
leg cramps0.00003
asthma0.00003
vaginal candidiasis0.00003
breast cancer0.00003
hypocalcemia0.00003
myocardial infarction0.00003
stroke0.00003
porphyria0.00003
endometrial hyperplasia0.00002
ectropion0.00002
uterine leiomyomata0.00002
ovarian cancer0.00002
endometrial cancer0.00002
sweating0.0
seizures0.0
muscle cramps0.0
faintness0.0
erythema0.0
shortness of breath0.0
cervical cancer0.0
abnormal mammogram0.0
wheezing0.0
benign tumors0.0
deep vein thrombosis0.0
hot flush0.0
endometriosis0.0
chest pain0.0
fatigue0.0
bleeding0.0
cerebrovascular disease0.0
cancer0.0
drowsiness0.0
diabetes0.0
hair loss0.0
birth defects0.0
heart disease0.0
lupus0.0
carcinomas0.0
alkaline phosphatase increased0
cervical erosion0
neck rigidity0
carpal tunnel syndrome0
conjunctivitis0
vertigo0
viral infection0
dermatitis0
cyst0
vulvovaginitis0
cystitis0
cough0
connective tissue disorders0
agitation0
emotional lability0
peripheral edema0
common cold0
skin irritation0
porphyria cutanea tarda0
vaginal discharge0
dental abscess0
toxic shock syndrome0
amnesia0
amenorrhea0
ear infection0
increased sweating0
acne0
abdominal distention0
kidney carcinoma0
breast neoplasm0
asthenia0
bacterial infections0
lymphadenopathy0
malaise0
myalgia0
abdominal pain upper0
bronchitis0
bronchospasm0
breast malformation0
breast swelling0
breast disorders0
clotting0
blepharitis0
varicose vein0
contact dermatitis0
menstrual flow0
hypercalcemia0
herpes zoster0
palpitations0
herpes simplex0
paresthesia0
hemorrhoids0
pneumonia0
polyuria0
hematuria0
postmenopausal bleeding0
otitis media0
osteoarthritis0
optic neuritis0
mediastinal disorders0
musculoskeletal pain0
fungal infection0
laryngitis0
nail disorder0
nasal congestion0
irritability0
hypernatremia0
hyperesthesia0
neuritis0
hematoma0
hepatitis0
toothache0
ulcer0
endocrine disorders0
emotional disturbances0
urinary incontinence0
embolism0
basal cell carcinoma0
ear pain0
vaginal pruritus0
diverticulitis0
tooth disorder0
tinnitus0
ocular infection0
tension headache0
purpura0
goiter0
gastroesophageal reflux0
gastroenteritis0
gastritis0
skin ulcer0
spasm0
pathological fracture0
fever0
diarrhea0

Target

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Uniprot ID:STS_HUMAN
Synonyms:
Arylsulfatase C
ASC
Steroid sulfatase
Steryl-sulfatase
Steryl-sulfate sulfohydrolase
EC-Numbers:3.1.6.2
Organism:Homo sapiens
Human
PDB IDs:1P49
Structure:
1P49

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
--84000-

References: