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Drug-Target Interaction

Drug

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PubChem ID:5312120
Structure:
Synonyms:
144092-31-9
4-[(E)-2-(7-heptoxy-4,4-dimethyl-1,1-dioxo-2,3-dihydrothiochromen-6-yl)pro
AC1NSM1L
Benzoic acid, 4-(2-(7-(heptyloxy)-3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)-1-propenyl)-, S,S-dioxide, (E)-
C084904
CID5312120
LG-629
LG629
R0-415253
Ro 41-5253
Ro-41-5253

Target

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Uniprot ID:RARA_HUMAN
Synonyms:
Nuclear receptor subfamily 1 group B member 1
RAR-alpha
Retinoic acid receptor alpha
EC-Numbers:-
Organism:Homo sapiens
Human
PDB IDs:1DKF 1DSZ
Structure:
1DSZ

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

16872382
Effect of all-trans-retinoic acid on the differentiation, maturation and functions of dendritic cells derived from cord blood monocytes.. Yuehong Tao; Yi Yang; Weiping Wang (2006) FEMS immunology and medical microbiology display abstract
We investigated the effects of all-trans-retinoic acid on dendritic cells derived from human cord blood monocytes to clarify how vitamin A affects immune function in children. Monocytes were separated from 18 cord blood samples, and dendritic cells were differentiated by culture. The percentage of dendritic cells was markedly lower in all-trans-retinoic acid treated cells than in untreated cells. After exposure to tumour necrosis factor-alpha for 3 days, all-trans-retinoic acid treated dendritic cells showed a reduced capacity to activate alloreactive T cells compared to untreated cells. In addition, all-trans-retinoic acid-treated dendritic cells could drive T cells towards T-helper cell type 2 responses with decreased secretion of interleukin-12, interferon-gamma, and increased production of interleukin-10 and interleukin-4. However, when Ro 41-5253, a selective retinoic acid receptor alpha antagonist, was add to culture, all the above actions were reversed. Thus, all-trans-retinoic acid may act at the first step of the immune response by inhibiting the differentiation of dendritic cells, maturation and induction of the T-helper cell type-2 response. The actions of all-trans-retinoic acid on dendritic cells were mediated through retinoic acid receptor alpha.