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Drug-Target Interaction

Drug

show drug details
PubChem ID:5291
Structure:
Synonyms:
152459-95-5
1iep
1xbb
4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE
4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide methanesulfonate
4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
4-[(4-methylpiperazin-1-yl)methyl]-N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}benzamide
alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-tolu-p-toluidide
alpha-(4-methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-toluidide
Benzamide,
Benzamide, 4-((4-methyl)-1-piperazinyl)methyl)-N-(4-methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)phenyl)-
Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]- (9CI)
CCRIS 9076
Cgp 57148
CGP 57148B
CHEBI:45783
DB00619
DB03261
Gleevec
Glivec
Imatinib
Imatinib Mesylate
Imatinib Methansulfonate
Imatinib [INN:BAN]
LS-182208
LS-187106
N-(3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide
NCGC00159456-02
NCGC00159456-03
NCGC00159456-04
nchembio.117-comp23
nchembio.162-comp5
nchembio.83-comp14
STI
STI 571
sti-571
STI571
STK617705
STOCK6S-47743
ATC-Codes:
Side-Effects:
Side-EffectFrequency
nausea0.4300001
musculoskeletal pain0.28000003
diarrhea0.26666668
vomiting0.26166666
fatigue0.258
muscle cramps0.22173686
edema0.19282351
arthralgia0.185
abdominal pain0.17666666
headache0.17099999
neutropenia0.1550244
dyspepsia0.1525
fever0.1481875
thrombocytopenia0.12565787
hemorrhage0.125
asthenia0.1184
weight gain0.11631249
cough0.1045
myalgia0.10366666
dyspnea0.099833325
nasopharyngitis0.098400004
pharyngitis0.0925
rash0.08903123
anemia0.08858535
anorexia0.08
night sweats0.07666666
pneumonia0.07000001
dizziness0.06933333
upper respiratory tract infection0.068799995
sinusitis0.061000004
insomnia0.060499996
hypokalemia0.057999995
constipation0.056599997
chest pain0.052000005
pruritus0.049399998
gastrointestinal hemorrhage0.042333335
influenza0.030666666
anxiety0.029439993
elevated alkaline phosphatase0.017857144
elevated sgot0.017222222
psoriasis0.009999999
sexual dysfunction0.009999999
peripheral neuropathy0.009999999
purpura0.009999999
menorrhagia0.009999999
herpes zoster0.009999999
hypotension0.009999999
nail disorder0.009999999
hypertension0.009999999
breast enlargement0.009999999
pancytopenia0.009999999
herpes simplex0.009999999
hematuria0.009999999
renal failure0.009999999
exfoliative dermatitis0.009999999
dehydration0.009999999
weight decreased0.009999999
hypophosphatemia0.009999999
dry skin0.009999999
migraine0.009999999
ldh increased0.009999999
sepsis0.009999999
peripheral coldness0.009999999
photosensitivity0.009999999
urinary frequency0.009999999
somnolence0.009999999
vertigo0.009999999
gout0.009999999
sciatica0.009999999
gastroenteritis0.009999999
gastritis0.009999999
flushing0.009999999
gastric ulcer0.009999999
syncope0.009999999
dry eye0.009999999
tachycardia0.009999999
tinnitus0.009999999
alopecia0.009999999
cardiac failure0.009181817
paresthesia0.0055
mouth ulceration0.0028000001
abdominal distension0.0028000001
gastroesophageal reflux0.0028000001
hepatitis0.0028000001
stevens - johnson syndrome0.001818182
dts0.0010
convulsions0.0010
diverticulitis0.0010
vitreous hemorrhage0.0010
vascular disorders0.0010
embolism0.0010
eosinophilia0.0010
erythema multiforme0.0010
conjunctivitis0.0010
glaucoma0.0010
retinal hemorrhage0.0010
acute febrile neutrophilic dermatosis0.0010
hepatic failure0.0010
confusion0.0010
aplastic anemia0.0010
osteonecrosis0.0010
shortness of breath0.0010
angioedema0.0010
vision blurred0.0010
ascites0.0010
cancer0.0010
vaginal discharge0.0010
avascular necrosis0.0010
interstitial pneumonitis0.0010
joint swelling0.0010
cardiac tamponade0.0010
colitis0.0010
cardiac disease0.0010
pulmonary fibrosis0.0010
infections0.0010
pericarditis0.0010
jaundice0.0010
leukemia0.0010
sarcoma0.0010
acute lymphoblastic leukemia0.0010
chronic myeloid leukemia0.0010
hyperkalemia0.0010
papilledema0.0010
pancreatitis0.0010
hyponatremia0.0010
tumor0.0010
lymphoma0.0010
hypersensitivity0.0010
mpd0.0010
watery eyes0
nephrosis0
myelodysplastic syndrome0
pain0
dyspnea on exertion0
elevated liver enzymes0
cardiomyopathy0
lymphopenia0
leukopenia0
back pain0
nephropathy0
blistering0
sore throat0
memory impairment0
cerebral hemorrhage0
bone pain0
petechiae0
congestive heart failure0
epistaxis0
pleural effusion0
flatulence0
blood dyscrasia0
shock0
alveolar proteinosis0
rhinitis0
pulmonary edema0
melena0
ecchymosis0
hepatic necrosis0
varicella0
weakness0
lower respiratory infection0
constitutional symptoms0
peripheral edema0
papilloma0
dermatitis0
pericardial effusion0
viral infection0
gynecomastia0

Target

show target details
Uniprot ID:EPHB1_HUMAN
Synonyms:
ELK
Ephrin type-B receptor 1
HEK6
NET
Tyrosine-protein kinase receptor EPH-2
EC-Numbers:2.7.10.1
Organism:Homo sapiens
Human
PDB IDs:2DJS 2EAO
Structure:
2EAO

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
->10000--

References: