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Drug-Target Interaction

Drug

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PubChem ID:5281787
Structure:
Synonyms:
104594-70-9
115610-29-2
2-phenylethyl 3-(3,4-dihydroxyphenyl)-2-propenoate
2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, 2-phenylethyl ester
2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, 2-phenylethyl ester, (E)-
AC1NQZ32
AIDS-028600
AIDS028600
BRD-K84709232-001-02-6
BRD-K96188950-001-02-9
BRD-K96188950-001-04-5
BSPBio_001560
BSPBio_003586
C 8221
C-1400
C055494
C10484
C8221_SIGMA
Caffeic acid 2-phenylethyl ester
Caffeic acid phenethyl ester
Caffeic Acid Phenethyl Ester, Synthetic
CAPE
CAPE compound
Capeee
CCG-39542
CHEBI:271563
CHEMBL319244
EU-0100269
HMS1361N22
HMS1791N22
HMS1989N22
HMS2233J04
HMS3260F20
I01-0894
IDI1_034030
Jsp000448
Lopac0_000269
LS-123626
MLS000859889
MLS002207297
MolPort-003-665-504
NCGC00093727-01
NCGC00093727-02
NCGC00093727-03
NCGC00093727-04
NCGC00093727-05
NCGC00093727-06
NCGC00093727-07
NCGC00093727-08
NCGC00093727-09
phenethyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
Phenethyl caffeate
Phenylethyl caffeate
QTL1_000016
SMR000326751
SPECTRUM1502209
ST51051549
ZINC00001083

Target

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Uniprot ID:ICE_DROME
Synonyms:
Caspase
drICE
EC-Numbers:3.4.22.-
Organism:Drosophila melanogaster
Fruit fly
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

14599484
Caffeic acid phenethyl ester blocks apoptosis induced by low potassium in cerebellar granule cells.. Rosalba Amodio; Caterina De Ruvo; Andrea Sacchetti; Angelomaria Di Santo; Nicola Martelli; Vincenzo Di Matteo; Roberto Lorenzet; Andreina Poggi; Domenico Rotilio; Marisa Cacchio; Ennio Esposito (2003) International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience display abstract
Primary cultures of cerebellar granule neurons (CGNs) were prepared from 8-day-old Wistar rats, and maintained in an appropriate medium containing a high (25 mM) concentration of KCl. To induce apoptosis, culture medium was replaced with serum-free medium (containing 5mM KCl) 8 days after plating. Apoptosis was measured by the terminal deoxynucleotidyl transferase-mediated dUTP-fluorescein nick end-labeling (TUNEL) method, and by flow cytometry. Since there is evidence that an increased formation of reactive oxygen species (ROS) is involved in the apoptosis induced by low K(+) (5mM) concentrations, the potential anti-apoptotic effect of caffeic acid phenethyl ester (CAPE), a potent flavonoid antioxidant, was tested in this experimental model. It was found that CAPE (10 microg/ml) promoted cell survival and was capable of blocking the apoptotic process as assayed by both TUNEL and flow cytometric methods. The same concentration of CAPE prevented the formation of ROS induced by low K(+). Since there is evidence that low K(+)-induced apoptosis in CGNs is associated with a drop in intracellular Ca(2+) concentration ([Ca(2+)](i)), activation of the cell death effector proteases caspase-3 and caspase-9, and of the transcription factor nuclear factor kappa B (NF-kappaB), the interference of CAPE with these purported mediators of apoptosis was also evaluated. It was found that CAPE did not interfere with the marked decrease in [Ca(2+)](i) induced by low K(+), whereas it completely blocked caspase-3, caspase-9, and NF-kappaB activation. It is concluded that CAPE could exert its anti-apoptotic effect in CGNs by blocking ROS formation and by inhibiting caspase activity.