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Drug-Target Interaction

Drug

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PubChem ID:5281672
Structure:
Synonyms:
2-(3,4,5-TRIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-4H-1-BENZOPYRAN-4-ONE
2o63
3,3 ,4 ,5,5 ,7-Hexahydroxyflavone
3,3',4',5,5',7-Hexahydroxyflavone
3,3',4',5,5',7-hexOH-Flavone
3,3',4,4',5',7-Hexahydro-2-phenyl-4H-chromen-4-one
3,3'4'5,5'7-hexOH-Flavone
3,5,7,3',4',5'-Hexahydroxyflavone
3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one
3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE
3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one
4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-
4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)- (9CI)
5-18-05-00670 (Beilstein Handbook Reference)
529-44-2
70050_FLUKA
70050_SIGMA
AC-4533
AC1NQYV4
ACon1_000267
AIDS-001411
AIDS001411
BIDD:ER0142
BIDD:PXR0079
Bio-0838
BPBio1_000628
BRD-K43149758-001-04-5
BRN 0332331
BSPBio_000570
C040015
C07E0ED2-ABF6-4BD3-A2B2-A98CAEF20FD1
C10107
Cannabiscetin
CAS-529-44-2
CCG-204825
CCRIS 5838
CHEBI:18152
CHEMBL164
DB02375
DivK1c_006627
EINECS 208-463-2
EU-0100740
FLAVONE, 3,3',4',5,5',7-HEXAHYDROXY-
HMS1569M12
HMS2096M12
HMS2231L04
HMS3262C22
KBio1_001571
KBio2_001981
KBio2_004549
KBio2_007117
KBioGR_001884
KBioSS_001981
LMPK12110001
Lopac-M-6760
Lopac0_000740
LS-69005
M 6760
M6760_SIGMA
MEGxp0_000357
MLS002153825
MolPort-001-740-532
MYC
Myricetin
Myricetin, Cannabiscetin, Myricetol, Myricitin)
Myricetin-Supplied by Selleck Chemicals
Myricetol
Myricitin
NCGC00015697-01
NCGC00015697-02
NCGC00015697-03
NCGC00015697-04
NCGC00015697-05
NCGC00015697-06
NCGC00015697-07
NCGC00015697-08
NCGC00015697-09
NCGC00015697-10
NCGC00015697-11
NCGC00015697-12
NCGC00015697-13
NCGC00094083-01
NCGC00094083-02
NCGC00094083-03
NCGC00094083-04
NCGC00179517-01
NCGC00179517-02
NCI60_003870
NSC 407290
NSC-407290
NSC407290
Prestwick0_000465
Prestwick1_000465
Prestwick2_000465
Prestwick3_000465
Prestwick_342
S00115
S2326_Selleck
SMR001233193
SPBio_002509
SpecPlus_000531
Spectrum4_001272
Spectrum5_000692
Spectrum_001501
ST057235
TNP00286
ZINC03874317

Target

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Uniprot ID:C0LQ91_MOUSE
Synonyms:
Lipase
Lipase, endothelial
EC-Numbers:-
Organism:Mouse
Mus musculus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

18598171
Inhibitory effect of Myrica bark on lipase activity in mouse plasma and gastrointestinal tract.. Kyoko Kobayashi; Satomi Ihara; Ayumi Kobata; Kana Itoh; Nae Kusunoki; Fumihiko Yoshizaki (2008) Journal of medicinal food display abstract
As the methanol extract of Myrica bark inhibited the activity of lipase in isolated mouse plasma in vitro, the influence of the extract on this enzyme in the gastrointestinal tube was investigated after oral intake. The methanol extract depressed the elevation of blood triglyceride level in olive oil-fed mice. Myricetin and gallic acid were suspected to be responsible for the inhibition of the lipase activity in isolated mouse plasma in vitro. The contents of myricetin and gallic acid in the methanol extract seemed to be insufficient for the appearance of the depressive activity of the extract on lipase in the gastrointestinal tract in vivo. Myricitrin, which is present in abundance in the methanol extract (about 61%), did not show the inhibitory activity. However, this material suppressed the elevation of blood triglyceride level to a slightly smaller extent compared with the methanol extract by oral administration. Consequently, it was proposed that myricitrin may function as a prodrug, which reveals its activity after conversion to myricetin, the active substance, by enterobacilli in the gastrointestinal tract.