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Drug-Target Interaction

Drug

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PubChem ID:5281612
Structure:
Synonyms:
3',5,7-trihydroxy-4'-methoxyflavone
4'-Methylluteolin
4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-
5,7,3'-Trihydroxy-4'-methoxyflavone
5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone
5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one
5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one
520-34-3
AC1NQYQA
AIDS-214630
AIDS214630
BB_NC-2600
BRD-K26862302-001-02-9
BSPBio_002653
C039602
C10038
CCG-38758
CHEBI:4630
CHEMBL90568
Diosmetin
Diosmetin, Luteolin 4-methyl ether
Diosmetin-Supplied by Selleck Chemicals
DivK1c_006531
EINECS 208-291-8
I06-0517
KBio1_001475
KBio2_001985
KBio2_004553
KBio2_007121
KBio3_001873
KBioGR_001586
KBioSS_001985
LMPK12110824
LS-193890
Luteolin 4'-methyl ether
MolPort-003-665-821
NCGC00163540-01
NCGC00163540-02
NCGC00178549-01
S2380_Selleck
SDCCGMLS-0066783.P001
SPBio_001735
SpecPlus_000435
Spectrum2_001638
Spectrum3_000987
Spectrum4_001113
Spectrum5_001707
Spectrum_001505
ST5331610
ZINC05733652

Target

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Uniprot ID:CP1A1_HUMAN
Synonyms:
CYPIA1
Cytochrome P450 1A1
P450 form 6
P450-C
P450-P1
EC-Numbers:1.14.14.1
Organism:Homo sapiens
Human
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----
----
--140-

References:

10781868
Bioflavonoids: selective substrates and inhibitors for cytochrome P450 CYP1A and CYP1B1.. H Doostdar; M D Burke; R T Mayer (2000) Toxicology display abstract
Interactions of six naturally occurring flavonoids (acacetin, diosmetin, eriodictyol, hesperetin, homoeriodictyol, and naringenin) with human cytochrome P450 (CYP1) enzymes were studied. The flavones acacetin and diosmetin were potent inhibitors of ethoxyresorufin O-dealkylase (EROD) activity of CYP1A and CYP1B1. Hydroxy and/or methoxy substitutions at the 3' and 4' positions in the flavonoid structures were the major factors involved in conveying selectivity for the different cytochrome P450 enzymes. Eriodictyol, homoeriodictyol and naringenin were very poor inhibitors of human CYP1A EROD activity (IC(50)4 microM). Hesperetin and homoeriodictyol selectively inhibited human CYP1A1 and CYP1B1. Only homoeriodictyol selectively inhibited human CYP1B1 (IC(50) 0.24 microM). Hesperetin was O-demethylated by both human CYP1A1 and 1B1 to eriodictyol, which was then further metabolized by the same enzymes. Hesperetin was not metabolized by human CYP1A2 or CYP3A4.
9661887