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Drug-Target Interaction

Drug

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PubChem ID:5280637
Structure:
Synonyms:
2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside
2-(3,4-Dihydroxyphenyl)-7-(beta-D-glucopyranosyloxy)-5-hydroxy-4H-1-benzop
2-(3,4-Dihydroxyphenyl)-7-(beta-D-glucopyranosyloxy)-5-hydroxy-4H-1-benzopyran-4-one
26811-41-6
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-, mono-beta-D-glucopyranoside
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-7-(beta-D-glucopyranosyloxy)-5-hydroxy-
5373-11-5
7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-one
7-Glucoluteolin
7-Glucosylluteolin
7-O-beta-D-Glucosyl-5,7,3',4'-tetrahydroxyflavone
AIDS-070478
AIDS070478
C03951
CHEBI:27994
Cinaroside
Cynaroside
EINECS 226-365-8
Flavon, 3',4',5,7-tetrahydroxy-, glucoside
Flavone, 3',4',5,7-tetrahydroxy-, mono-beta-D-glucopyranoside
Glucoluteolin
LS-39606
Luteolin 7-glucoside
Luteolin 7-monoglucoside
Luteolin 7-O-beta-D-glucoside
Luteolin 7-O-D-glucoside
Luteolin 7-O-glucopyranoside
Luteolin 7-O-glucoside
Luteolin monoglucoside
Luteolin, glucoside
Luteolin-7-glucoside
LUTEOLIN-7-O-BETA-D-GLUCOSIDE
Luteolin-7-O-glucoside
Luteoloside
MEGxp0_000619
NCGC00163589-01
STOCK1N-08497
ZINC04096258

Target

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Uniprot ID:AKT1_MOUSE
Synonyms:
AKT1 kinase
C-AKT
PKB
Protein kinase B
RAC-alpha serine/threonine-protein kinase
RAC-PK-alpha
Thymoma viral proto-oncogene
EC-Numbers:2.7.11.1
Organism:Mouse
Mus musculus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References:

16491846
The inhibitory effect and mechanism of luteolin 7-glucoside on rat aortic vascular smooth muscle cell proliferation.. Tack-Joong Kim; Jin-Ho Kim; Yong-Ri Jin; Yeo-Pyo Yun (2006) Archives of pharmacal research display abstract
The abnormal proliferation of aortic vascular smooth muscle cells (VSMCs) plays a central role in the pathogenesis of atherosclerosis and restenosis after angioplasty and possibly also in the development of hypertension. The present study was designed to examine the inhibitory effects and the mechanism of luteolin 7-glucoside (L7G) on the platelet-derived growth factor (PDGF)-BB-induced proliferation of VSMCs. L7G significantly inhibited the PDGF-BB-induced proliferation and the DNA synthesis of the VSMCs in a concentration-dependent manner. Pre-incubation of the VSMCs with L7G significantly inhibited the PDGF-BB-induced extracellular signal-regulated kinase 1/2 (ERK1/2), Akt and the phospholipase C (PLC)-gamma1 activation. However, L7G had almost no affect on the phosphorylation of PDGF-beta receptor tyrosine kinase, which was induced by PDGF-BB. These results suggest that L7G inhibits the PDGF-BB-induced proliferation of VSMCs via the blocking of PLC-gamma1, Akt, and ERK1/2 phosphorylation.