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Drug-Target Interaction

Drug

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PubChem ID:5240
Structure:
Synonyms:
00652_FLUKA
2-Iodoacetic acid
4-02-00-00534 (Beilstein Handbook Reference)
64-69-7
AC1L1JWR
Acetic acid, 2-iodo-
Acetic acid, iodo-
Acetic acid, iodo- (8CI,9CI)
Acid, Iodoacetic
Acid, Monoiodoacetic
AI3-52119
AKOS000118792
AR-1J2413
BBL003946
BB_SC-6475
BRN 1739079
C2H3IO2
CCRIS 667
CHEMBL376280
D019807
EINECS 200-590-1
HSDB 4008
I04-1111
I4386_SIAL
IA
Iodoacetate
Iodoacetic acid
JDNTWHVOXJZDSN-UHFFFAOYSA-
Kyselina jodoctova
Kyselina jodoctova [Czech]
LS-1544
MIA
MolPort-002-990-500
Monoiodine acetate
Monoiodo Acetate
Monoiodoacetate
Monoiodoacetic acid
NCGC00188891-01
NSC 2125
NSC2125
sJPhLQVIKTp@
STK263695
WLN: QV1I

Target

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Uniprot ID:ICE_DROME
Synonyms:
Caspase
drICE
EC-Numbers:3.4.22.-
Organism:Drosophila melanogaster
Fruit fly
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

11833936
Inhibitors of caspase homologues suppress an apoptotic phenotype in cultured rabbit corpora lutea.. M A Abdo; A Richards; N Atiya; B Singh; S Parkinson; S Hisheh; A M Dharmarajan (2001) Reproduction, fertility, and development display abstract
Apoptosis is a morphologically defined type of cell death initiated by various stimuli that results in the activation of caspases (cysteine-containing aspartate-specific proteases). In the present study, it was determined that caspases are present during, and play a role in, corpus luteum (CL) apoptosis in vitro. Pseudopregnancy was induced in rabbits with 100 IU human chorionic gonadotrophin. On Day 11 of pseudopregnancy, CL were isolated and cultured for 0, 2, 4, 6, and 8 h in the absence of trophic support to induce spontaneous apoptosis. Total RNA was extracted and analysed for caspase-I expression by Northern blot analysis. The results demonstrated caspase-I expression from 4 h. In the second part of the study, CL were incubated without trophic support for 4 h with increasing concentrations of three general caspase inhibitors, sodium aurothiomalate (SAM), iodoacetic acid (IAA) and N-tosyl-L-phenylalanylchloromethylketone (TPCK), and two specific caspase inhibitors, N-acetyl (Ac)-Tyr-Val-Ala-Asp (YVAD)-chloromethylketone (CMK) (Ac-YVAD-CMK) and Ac-Asp-Glu-Val-Asp (DEVD)-aldehyde (CHO) (Ac-DEVD-CHO). At completion, DNA was isolated and integrity assessed. Treatment of CL with SAM, IAA or Ac-DEVD-CHO effectively suppressed apoptotic DNA fragmentation. The final component of the study was to examine caspase-3 protein expression. Western blot analysis revealed a significant increase in caspase-3 expression over the experimental time-course. The results of the present study clearly demonstrate a time-dependent link between the caspases, specifically caspase-3 and spontaneous apoptosis in the rabbit CL.