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Drug-Target Interaction

Drug

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PubChem ID:5195
Structure:
Synonyms:
"cpd without isomeric designation; deprenyl"
(+)-deprenyl
(+-)-Deprenyl
(R)-((-))-N,.alpha.-Dimethyl-N-2-propynylphenethylamine
1,N-Dimethyl-N-propargyl-2-phenylethylamine
2323-36-6
4-fluorodeprenyl, (-)-isomer
AC1L1JT6
AC1Q2862
AR-1L0637
Benzeneethanamine, N,alpha-dimethyl-N-2-propynyl-
Benzeneethanamine, N,alpha-dimethyl-N-2-propynyl- (9CI)
C13H17N
CHEBI:118032
CHEBI:50217
CHEMBL8663
cpd without isomeric designation
cpd without isomeric designation; deprenyl
Deprenil
Deprenyl
HMS2089B08
LS-103418
LS-171873
N,alpha-Dimethyl-N-2-propynylbenzeneethanamine
N,alpha-Dimethyl-N-2-propynylphenethylamine
N-methyl-1-phenyl-N-prop-2-ynylpropan-2-amine
N-methyl-N-(1-methyl-2-phenylethyl)prop-2-yn-1-amine
NCGC00015624-03
NCGC00016708-02
NCGC00162273-01
Phenethylamine, N,.alpha.-dimethyl-N-2-propynyl-
PHENETHYLAMINE, N,alpha-DIMETHYL-N-2-PROPYNYL-
phenylisopropyl-n-methylpropinylamine
R-(-)-Deprenyl hydrochloride
Selegiline
ATC-Codes:
Side-Effects:
Side-EffectFrequency
sweating1.0
acne1.0
pruritus1.0
chest pain1.0
neck pain1.0
metrorrhagia1.0
dysmenorrhea1.0
myalgia1.0
gastroenteritis1.0
urinary frequency1.0
pathological fracture1.0
ecchymosis1.0
cough1.0
peripheral edema1.0
tinnitus1.0
amnesia1.0
constipation1.0
flatulence1.0
anorexia1.0
bronchitis1.0
hypertension0.667
emesis0.667
urinary tract infection0.505
paresthesia0.34
agitation0.334
dry skin0.01
abnormal liver function tests0.01
fever0.01
hematuria0.01
rash0.01
eructation0.01
vaginal hemorrhage0.01
hyponatremia0.01
hyperglycemia0.01
hyperesthesia0.01
flank pain0.01
hypercholesteremia0.01
gastritis0.01
herpes simplex0.01
glossitis0.01
pneumonia0.01
hernia0.01
eye pain0.01
neck rigidity0.01
migraine0.01
pelvic pain0.01
periodontal abscess0.01
viral infection0.01
vertigo0.01
polyuria0.01
vaginitis0.01
urticaria0.01
tremor0.01
increased salivation0.01
spasm0.01
tenosynovitis0.01
otitis media0.01
neurosis0.01
arthrosis0.01
kidney calculus0.01
leg cramps0.01
breast pain0.01
melena0.01
menorrhagia0.01
fungal infection0.01
urinary urgency0.01
tachycardia0.01
chills0.01
peripheral vascular disorder0.01
suicide attempt0.01
skin benign neoplasm0.01
vaginal moniliasis0.01
dehydration0.01
tooth caries0.01
lymphadenopathy0.01
contact dermatitis0.01
cystitis0.01
fungal dermatitis0.01
breast neoplasm0.01
dysphagia0.01
arthralgia0.01
arthritis0.01
bacterial infection0.01
atrial fibrillation0.01
herpes zoster0.01
colitis0.01
asthma0.01
confusion0.01
conjunctivitis0.01
cyst0.01
anemia0.01
photosensitivity0.01
dry eyes0.01
dysuria0.01
amenorrhea0.01
dyspnea0.01
edema0.01
ear pain0.01
alopecia0.01
impotence0.0070
syncope0.0069999998
neoplasm0.0055
decreased libido0.0035
petechia0.0010
convulsions0.0010
laryngitis0.0010
parkinson0.0010
pain0.0010
osteoporosis0.0010
moniliasis0.0010
leukocytosis0.0010
myocardial infarct0.0010
leukopenia0.0010
epistaxis0.0010
eczema0.0010
ataxia0.0010
coma0.0010
rectal hemorrhage0.0010
chronic renal failure0.0010
headache0.0010
otitis external0.0010
malaise0.0010
bilirubinemia0.0010
hallucinations0.0010
halitosis0.0010
visual field defect0.0010
seizure0.0010
vascular collapse0.0010
dizziness0.0010
infection0.0010
drowsiness0.0010
hypotension0.0010
diaphoresis0.0010
cardiomyopathy0
weight gain0
tooth disorder0
tardive dyskinesia0
erythema0
abnormal vision0
vascular disorders0
allergic reaction0
prostatic hypertrophy0
cerebral ischemia0
sleep disorder0
urinary incontinence0
thinking abnormal0
ulcer0
skin carcinoma0
weight loss0
myocardial ischemia0
dizziness and vertigo0
bone pain0
blindness0
neuropathy0
shortness of breath0
esophageal ulcer0
urinary hesitancy0
lightheadedness0
voice alteration0
blurred vision0
visual hallucinations0
memory impairment0
ankle edema0
bigeminy0
dementia0
esr increased0
prostatic specific antigen increase0
dry mouth0
urinary retention0
lung cancer0
breast cancer0
encephalopathy0
prostate cancer0
abnormal gait0
sinus bradycardia0
av block first degree0
apathy0
emotional lability0
falling down0
hyperphosphatemia0
cataract0
manic0
personality change0
supraventricular tachycardia0
albuminuria0
euphoria0
esophagitis0
epididymitis0
eosinophilia0
abdominal pain0
dyspepsia0
dyskinesia0
diplopia0
gastrointestinal hemorrhage0
gingivitis0
subdural hematoma0
hematoma0
heartburn0
congestive heart failure0
cardiomegaly0
cardiac arrest0
gout0
glaucoma0
diarrhea0
diabetes mellitus0
atrial flutter0
asthenia0
arrhythmia0
apraxia0
aphasia0
anxiety0
angina pectoris0
amblyopia0
back pain0
blepharospasm0
depersonalization0
delusions0
delirium0
deafness0
cholecystitis0
cellulitis0
bursitis0
bruxism0
hemorrhage0
hepatitis0
hiccup0
pleural effusion0
pharyngitis0
personality disorder0
peptic ulcer0
weakness0
palpitations0
nocturia0
numbness0
pneumothorax0
sexual dysfunction0
skin ulcer0
sinusitis0
seborrhea0
rhinitis0
retinal detachment0
retinal artery occlusion0
pulmonary edema0
psychosis0
nightmares0
neuritis0
leg pain0
irritability0
influenza0
postural hypotension0
hypokalemia0
hypoglycemia0
hyperlipidemia0
hyperkalemia0
myelogenous leukemia0
low back pain0
neuralgia0
nervousness0
nausea0
myopathy0
muscle cramps0
cholelithiasis0
melanoma0
lymphoma0
stomatitis0

Target

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Uniprot ID:Q7TNA8_RAT
Synonyms:
L-lactate dehydrogenase
EC-Numbers:1.1.1.27
Organism:Rat
Rattus norvegicus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

9564612
A cell culture model of cerebral ischemia as a convenient system to screen for neuroprotective drugs.. J Ekblom; H Garpenstrand; O Tottmar; J A Prince; L Oreland (1998) Journal of neural transmission. Supplementum display abstract
Aggregation cultures of rat brain were exposed to a combination of anoxia and hypoglycaemia for 30 minutes. Thereafter, the release of lactate dehydrogenase into the cell culture medium was monitored up to 4 days as a measure of cell damage after the ischemic insult. Some cultures were treated with different concentrations of deprenyl or tolcapone, selective inhibitors of monoamine oxidase B and catechol-O-methyltransferase, respectively. After 1 day in culture, the release of lactate dehydrogenase was significantly reduced in cultures treated with deprenyl (at 1 nM. 100 nM, and 10 microM), as well as in cultures treated with 1 nM or 100 nM tolcapone; 10 microM of tolcapone, on the other hand, resulted in a toxic effect on the cell aggregates. No differences in the release of lactate dehydrogenase into the medium was observed in the aggregates treated with drugs as compared with the control cultures after 2 or 4 days post-ischemia.