Home
Drugs
Targets
Pathways
Ontologies
Cyp450s
Adv.search
Help/FAQ

Drug-Target Interaction

Drug

show drug details
PubChem ID:5147
Structure:
Synonyms:
2-Carbamoylphenol
2-Carboxamidophenol
2-Hydroxybenzamide
2-HYDROXYBENZAMIDE (SEE ALSO:N-HYDROXYBENZAMIDE (CAS 495-18-1))
36205-82-0
36205-82-0 (mono-hydrochloride salt)
4-10-00-00169 (Beilstein Handbook Reference)
65-45-2
84228_FLUKA
860417_ALDRICH
AB1004776
AC1L1JPI
AC1Q4Z8X
Acket
Afko-Sal
AG-G-46401
AH-034/32461056
AI3-03454
AIDS-018403
AIDS018403
AKOS000120983
Algamon
Algiamida
Allevin
Amid kyseliny salicylove
Amid kyseliny salicylove [Czech]
Amid-Sal
Amidosal
Anamid
Andasol
BB_SC-0234
Benesal
Benesal (VAN)
Benzamide, 2-hydroxy-
Benzamide, o-hydroxy-
Benzoic acid, 2-hydroxy-, amide
BENZOIC ACID,2-HYDROXY,AMIDE SALICYLAMIDE
BENZOIC ACID,2-HYDROXY,AMIDE SALICYLAMIDE
BRD-K81130846-001-02-6
BRN 0742439
BSPBio_001948
C7H7NO2
CCG-39250
CCRIS 6045
Cetamide
CHEBI:32114
CHEMBL27577
component of Tolagesic
Cymidon
Cymidon (VAN)
D01811
DB08797
DivK1c_000858
Dolomide
Dropsprin
Eggosalil
EINECS 200-609-3
EU-0000058
Flarpirina
H.P. 34
HMS1920P14
HMS2092G15
HMS2232E07
HMS502K20
HSDB 227
I01-5217
IDI1_000858
KBio1_000858
KBio2_001426
KBio2_003994
KBio2_006562
KBio3_001448
KBioGR_001017
KBioSS_001426
Liquiprin
LS-1556
Mixture Name
MLS000069486
MolPort-001-641-072
Morsarinas
NCGC00091414-01
NCGC00091414-02
NCGC00091414-03
NCGC00091414-04
NCGC00091414-05
NCIOpen2_001127
NINDS_000858
Novecyl
NSC 3115
NSC3115
o-Hydroxybenzamide
OHB
Oprea1_069894
Oramid
Panithal
Raspberin
Rhinex D-Lay Tablets
S0006
Salamid
Salamide
Saliamid
Saliamin
Salicilamida
Salicilamida [INN-Spanish]
Salicilamide
Salicilamide [DCIT]
Salicilamide [Italian]
Salicim
Salicylamide
Salicylamide (JAN/USP/INN)
Salicylamide (TN)
Salicylamide [BAN:INN:JAN]
Salicylamide [INN:BAN:JAN]
Salicylamidum
Salicylamidum [INN-Latin]
Salicylic acid amide
Salipur
Salizell
Salizell (VAN)
Salrin
Salymid
SAM
Serramida
SMR000046394
SPBio_001403
SPECTRUM1500532
Spectrum2_001312
Spectrum3_000564
Spectrum4_000499
Spectrum5_001032
Spectrum_000946
SR 4326
STK301812
UNII-EM8BM710ZC
Urtosal
WLN: ZVR BQ
ZINC00002055
ATC-Codes:

Target

show target details
Uniprot ID:CP1A2_HUMAN
Synonyms:
CYPIA2
Cytochrome P450 1A2
P(3)450
P450 4
P450-P3
EC-Numbers:1.14.14.1
Organism:Homo sapiens
Human
PDB IDs:2HI4
Structure:
2HI4

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

14729655
The drug salicylamide is an antagonist of the aryl hydrocarbon receptor that inhibits signal transduction induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.. Christopher J MacDonald; Henry P Ciolino; Grace Chao Yeh (2004) Cancer research display abstract
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant, that has been linked with a variety of deleterious effects on human health, including increased cancer rates and reproductive anomalies. The detrimental effects of TCDD are mediated via the aryl hydrocarbon receptor (AhR), a transcription factor that regulates the expression of the carcinogen-activating enzymes cytochromes P-450 (CYP) 1A1, 1A2, and 1B1. In the present study, we examined the ability of synthetic derivatives of salicylic acid to affect TCDD-stimulated AhR-mediated signal transduction in human hepatoma HepG2 cells. Salicylamide (SAL), an analgesic drug, caused a potent and long-lasting inhibition of TCDD-induced CYP enzyme activity. Acetylsalicylic acid (aspirin) and the naturally occurring phytochemical salicylic acid had no effect on CYP activity. SAL inhibited the increase in CYP1A1, -1A2, and -1B1 mRNA levels that occurs on exposure to TCDD. TCDD-induced transcription of these genes was also inhibited by SAL, but not by aspirin or salicylic acid, as demonstrated by luciferase reporter assays. The transcription of the CYP1 family of genes is regulated by the interaction of TCDD-activated AhR with the xenobiotic-responsive element present in the promoter regions of these genes. As shown by electrophoretic mobility shift assay, SAL completely blocked the binding of TCDD-activated AhR to the xenobiotic responsive element. Also, SAL substantially blocked the binding of TCDD to the cytosolic AhR. These results demonstrate that SAL, a commonly used analgesic, is a potent inhibitor of AhR-mediated signal transduction, and may be an effective agent in the prevention of TCDD-associated disease.