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Drug-Target Interaction

Drug

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PubChem ID:51081
Structure:
Synonyms:
1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-methyl-1-piperazinyl)-3-quinolinec
1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-methyl-1-piperazinyl)-3-quinolinecarboxylic acid
1-Ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1- piperazinyl)-4-oxo-3-quinolinecarboxylic acid
1-Ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
1584RB
1589 RB
2589 R.B
3-Quinolinecarboxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-
3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo
3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-
5-23-03-00135 (Beilstein Handbook Reference)
70458-92-3
70458-95-6
70458-95-6 (MESYLATE)
Abactal
AIDS-008377
AIDS008377
AM-725
BAS 00463355
BRN 0567618
BSPBio_003571
C17H20FN3O3
CHEBI:50199
D02306
DB00487
EINECS 274-611-8
EU 5306
EU-5306
KBio3_002945
KS-1095
LS-141589
MLS000713556
Oprea1_063677
Oprea1_546341
Peflacine
Pefloxacin
Pefloxacin (USAN/INN)
Pefloxacin [INN-French]
Pefloxacin [USAN:BAN:INN]
Pefloxacine
Pefloxacino
Pefloxacino [INN-Spanish]
Pefloxacinum
Pefloxacinum [INN-Latin]
PFLX
Silver Pefloxacin
SMR000273037
SPBio_000127
Spectrum2_000034
Spectrum3_001971
ST5002806
STK169677
ATC-Codes:

Target

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Uniprot ID:GYRB_ECOLI
Synonyms:
DNA gyrase subunit B
EC-Numbers:5.99.1.3
Organism:Escherichia coli
strain K12
PDB IDs:1AJ6 1EI1 1KZN
Structure:
1KZN

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

2830840
Effect of DNA gyrase inhibitors pefloxacin, five other quinolones, novobiocin, and clorobiocin on Escherichia coli topoisomerase I.. X Tabary; N Moreau; C Dureuil; F Le Goffic (1987) Antimicrobial agents and chemotherapy display abstract
Two coumarins, inhibitors of the B subunit of DNA gyrase, and six quinolones, inhibitors of the A subunit, were tested against Escherichia coli topoisomerase I-catalyzed DNA relaxation. Coumarins had no effect, whereas quinolones were inhibitors of the enzyme. This inhibition was compared with that of DNA gyrase and calf thymus topoisomerase I. The 50% inhibitory concentrations for E. coli topoisomerase I were about one order of magnitude higher than the corresponding values for E. coli DNA gyrase but were far lower than the known values for calf thymus topoisomerase I. There was a good relationship between inhibition of the two prokaryotic topoisomerases and MICs for E. coli, and the quinolones could be ranked in the same order in the three cases.