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Drug-Target Interaction

Drug

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PubChem ID:50599
Structure:
Synonyms:
2',3'-Dideoxyinosine
2',3'-Dideoxyinosine & Granulocyte-macrophage colony-stimulating factor
2',3'-Dideoxyinosine & Interferon-.alpha.
2',3'-Dideoxyinosine & sCD4(soluble recombinant protein)
2',3'-Dideoxyinosine (AIDS Initiative)
2',3'-Dideoxyinosine (ddI)
2'3'-DIDEOXYINOSINE
2DI
3'-Azido-3'-deoxythymidine + 2',3'-Dideoxyinosine
69655-05-6
9-[(2R,5R)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL]-1,9-DIHYDRO-6H-PURIN-6-ONE
9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
9-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-o
9-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one
AIDS-000004
AIDS-000597
AIDS-000888
AIDS-001591
AIDS-005890
AIDS-007798
AIDS-058049
AIDS-352657
AIDS000004
AIDS000597
AIDS000888
AIDS001591
AIDS005890
AIDS007798
AIDS058049
AIDS352657
BB_NC-1318
BMY 40900
BMY-40900
BRN 3619529
C06953
CCRIS 805
CHEBI:490877
CPD000058576
D00296
d2I
DB00900
DdI
ddI & GM-CSF
ddI & IFN-.alpha.
ddI & sCD4(rsCD4)
ddI + d4T combination
DDI and rIFN.alpha.2
ddIno
Didanosina
Didanosina [INN-Spanish]
Didanosine
Didanosine (JAN/USAN/INN)
Didanosine and Interferon-.alpha.-2
Didanosine [USAN:BAN:INN]
Didanosinum
Didanosinum [INN-Latin]
DIDEOXYINOSINE
DRG-0016
DS-4152 & ddI
HSDB 6548
Hypoxanthine ddN
Inosine, 2',3'-dideoxy-
Inosine, 2',3'-dideoxy- & Recombinant Interferon-.alpha.-2
Intron A & Videx
KS-1049
Lecithinized superoxide dismutase & Inosine, 2',3'-dideoxy-
Listera ovata agglutinin & 2',3'-Dideoxyinosine
LOA & ddI
MLS000759469
MLS001055350
MLS001424118
MLS002154216
NCGC00090691-01
NCGC00159514-02
NCGC00159514-03
NSC 612049
NSC-612049
NSC612049
PC-SOD+ddI
SAM001246673
SMR000058576
Sulfated polysaccharide-peptidoglycan DS-4152 & 2',3'-Dideoxyinosine
Videx
Videx (TN)
Videx EC
Videx EC (slow-release capsules)
ZINC13597823
ATC-Codes:
Side-Effects:
Side-EffectFrequency
nausea0.43600005
diarrhea0.39388886
headache0.307
vomiting0.21499999
neuropathy0.16000001
rash0.13222222
abdominal pain0.08623076
pruritus0.072500005
pancreatitis0.030407403
hyperglycemia0.0010
pain0.0010
optic neuritis0.0010
rhabdomyolysis0.0010
peripheral neuropathy0.0010
sialoadenitis0.0010
parotid gland enlargement0.0010
dry eyes0.0010
myalgia0.0010
depigmentation0.0010
liver failure0.0010
chills0.0010
dry mouth0.0010
thrombocytopenia0.0010
myopathy0.0010
fever0.0010
diabetes mellitus0.0010
hepatic steatosis0.0010
asthenia0.0010
flatulence0.0010
arthralgia0.0010
anorexia0.0010
hepatitis0.0010
anemia0.0010
hypoglycemia0.0010
acute renal failure0.0010
alopecia0.0010
acidosis0.0010
leukopenia0.0010
dyspepsia0.0010
asymptomatic hyperuricemia0
weight gain0
lymphoma0
salmonella0
blood dyscrasia0
hepatomegaly0
breast enlargement0
obesity0
numbness0
hyperuricemia0

Target

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Uniprot ID:POL_HV1H2
Synonyms:
Gag-Pol polyprotein
Pr160Gag-Pol
EC-Numbers:-
Organism:HIV-1
Human immunodeficiency virus type 1
isolate HXB2 group M subtype B
PDB IDs:1A30 1BV7 1BV9 1BVE 1BVG 1BWA 1BWB 1C0T 1C0U 1C1B 1C1C 1DMP 1DTQ 1DTT 1E6J 1EP4 1ESK 1EX4 1EXQ 1FB7 1FK9 1FKO 1FKP 1G6L 1HIV 1HVH 1HVR 1HWR 1HXB 1JKH 1JLA 1JLB 1JLC 1JLE 1JLF 1JLG 1JLQ 1KLM 1LV1 1LW0 1LW2 1LWC 1LWE 1LWF 1NCP 1O1W 1ODW 1ODY 1QBR 1QBS 1QBT 1QBU 1REV 1RT1 1RT2 1RT3 1RT4 1RT5 1RT6 1RT7 1RTD 1RTH 1RTI 1RTJ 1S1T 1S1U 1S1V 1S1W 1S1X 1T05 1TAM 1TKT 1TKX 1TKZ 1TL1 1TL3 1VRT 1VRU 2HND 2HNY 2HNZ 2NPH 2OPP 2OPQ 2OPR 2OPS 2RF2 2RKI 3C6T 3C6U 3DI6 3DLE 3DLG 3DM2 3DMJ 3DOK 3DOL 3DOX 3DRP 3DRR 3DRS 3DYA 3E01 3I0R 3I0S 3PHV
Structure:
3PHV

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: