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Drug-Target Interaction

Drug

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PubChem ID:4993
Structure:
Synonyms:
2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine
2,4-Diamino-5-(p-chlorophenyl)-6-ethylpyrimidine
2,4-Diamino-5-chlorophenyl-6-ethylpyrimidine
2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-
2,4-Pyrimidinediamine, 5-(p-chlorophenyl)-6-ethyl-
46706_FLUKA
46706_RIEDEL
4753 r.p
4753 R.P.
5-(4'-Chlorophenyl)-2,4-diamino-6-ethylpyrimidine
5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE
5-(4-chlorophenyl)-2,4-diamino-6-ethylpyrimidine
5-(4-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine
5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidi nediamine
5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine
5-(p-chlorophenyl)-6-ethyl-2,4-diaminopyrimidine
5-25-12-00255 (Beilstein Handbook Reference)
5-[4-Chlorophenyl]-6-ethyl-2,4-pyrimidinediamine
58-14-0
AB00052084
AC-7879
AC1L1JDI
AI3-25005
AIDS-006885
AIDS-097730
AIDS-097733
AIDS-105153
AIDS-105155
AIDS006885
AIDS097730
AIDS097733
AIDS105153
AIDS105155
Aventis Brand of Pyrimethamine
AZT + Pyrimethamine combination
BIDD:GT0149
BIDD:PXR0173
BPBio1_000147
BRD-K88429204-001-05-4
BRN 0219864
BSPBio_000133
BSPBio_003282
BW 50-63
BW 5063
C07391
C12H13ClN4
CAS-58-14-0
CCG-39626
CCRIS 546
CD
CHEBI:8673
CHEMBL36
Chloridin
Chloridine
Chloridyn
CP6
CPD000058714
CRL-8131 & Pyrimethamine
CRL-8142 & Pyrimethamine
D00488
D011739
Darachlor
Daraclor
Darapram
Daraprim
Daraprim (TN)
Daraprim, Malocide, Pirimecidan, Pyrimethamine
Daraprime
Daraprin
DB00205
Diaminopyritamin
DivK1c_000652
DRG-0027
EINECS 200-364-2
Erbaprelina
Ethylpyrimidine
EXR-101
Fansidar
Fansidar (Pyrimethamine/Sulfadoxine)
Glaxo Wellcome Brand of Pyrimethamine
GlaxoSmithKline Brand of Pyrimethamine
HMS1568G15
HMS1920N12
HMS2092E13
HMS2095G15
HMS2235A17
HMS3259C04
HMS502A14
IDI1_000652
KBio1_000652
KBio2_001386
KBio2_003954
KBio2_006522
KBio3_002502
KBioGR_001007
KBioSS_001386
Khloridin
L000713
Lactoferrin B & Pyrimethamine
Lactoferrin H & Pyrimethamine
LS-238
m alocid
Malacid
Malocid
Malocide
Maloprim
Mixture Name
MLS000028606
MLS001148621
MLS002454446
MLS002701881
NCGC00016256-01
NCGC00016256-02
NCGC00016256-03
NCGC00016256-04
NCGC00016256-05
NCGC00016256-06
NCGC00016256-07
NCGC00016256-08
NCGC00016256-09
NCGC00016256-10
NCGC00016256-11
NCGC00016256-12
NCGC00016256-13
NCGC00016256-14
NCGC00023188-03
NCGC00023188-04
NCGC00023188-05
NCGC00023188-06
NCGC00023188-07
nchembio.215-comp13
nchembio.87-comp22
NCI-C01683
NCI60_002604
NCIOpen2_008313
NINDS_000652
NSC 3061
NSC-3061
NSC3061
Pirimecidan
Pirimetamin
Pirimetamina
Pirimetamina [INN-Spanish]
Pirimetamina [Spanish]
Prestwick0_000037
Prestwick1_000037
Prestwick2_000037
Prestwick3_000037
Prestwick_504
Primethamine
Pyremethamine
Pyrimethamin
Pyrimethamine
Pyrimethamine (JAN/USP/INN)
Pyrimethamine (Pyr)
Pyrimethamine Hcl
Pyrimethamine [USAN:BAN:INN:JAN]
Pyrimethamine [USAN:INN:BAN:JAN]
Pyrimethamine-Supplied by Selleck Chemicals
Pyrimethaminum
Pyrimethaminum [INN-Latin]
Pyrimidine, 2,4-diamino-5-(p-chlorophenyl)-6-ethyl-
RP 4753
S2006_Selleck
SAM002554921
SMR000058714
SPBio_000672
SPBio_002054
SPECTRUM1500520
Spectrum2_000886
Spectrum3_001701
Spectrum4_000494
Spectrum5_001447
Spectrum_000906
TCMDC-123831
TCMDC-125860
Tindurin
Tindurine
Tinduring
UNII-Z3614QOX8W
Wellcome Brand of Pyrimethamine
WLN: T6N CNJ BZ DZ ER DG& F2
WR 2978
ZINC00057464
ATC-Codes:
Side-Effects:
Side-EffectFrequency
anaphylaxis0
thrombocytopenia0
stevens - johnson syndrome0
pancytopenia0
leukopenia0
hypersensitivity0
hematuria0
glossitis0
erythema multiforme0
toxic epidermal necrolysis0
eosinophilia0
anorexia0
megaloblastic anemia0
vomiting0

Target

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Uniprot ID:CP2C9_HUMAN
Synonyms:
(R)-limonene 6-monooxygenase
(S)-limonene 6-monooxygenase
(S)-limonene 7-monooxygenase
CYPIIC9
Cytochrome P450 2C9
P-450MP
P450 MP-4/MP-8
P450 PB-1
S-mephenytoin 4-hydroxylase
EC-Numbers:1.14.13.48
1.14.13.49
1.14.13.80
Organism:Homo sapiens
Human
PDB IDs:1OG2 1OG5 1R9O
Structure:
1R9O

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----
51500.0---

References: