Home
Drugs
Targets
Pathways
Ontologies
Cyp450s
Adv.search
Help/FAQ

Drug-Target Interaction

Drug

show drug details
PubChem ID:4923
Structure:
Synonyms:
1-[amino-(4-chloroanilino)methylidene]-2-propan-2-ylguanidine
1-[amino-[(4-chlorophenyl)amino]methylidene]-2-propan-2-ylguanidine
AC1L1J8U
DB01131
Proguanil
ATC-Codes:
Side-Effects:
Side-EffectFrequency
diarrhea0.18888888
headache0.18857142
abdominal pain0.17333333
nausea0.1575
dizziness0.085
insomnia0.083333336
fever0.07857143
myalgia0.074999996
oral ulcers0.0675
cough0.0675
vomiting0.061249997
flu syndrome0.044
upper respiratory infection0.042000003
back pain0.04
pruritus0.035
dyspepsia0.024999999
anxiety0.023333333
gastritis0.016666666

Target

show target details
Uniprot ID:DYR_HUMAN
Synonyms:
Dihydrofolate reductase
EC-Numbers:1.5.1.3
Organism:Homo sapiens
Human
PDB IDs:1BOZ 1DHF 1DLR 1DLS 1DRF 1HFP 1HFQ 1HFR 1KMS 1KMV 1MVS 1MVT 1OHJ 1OHK 1PD8 1PD9 1PDB 1S3U 1S3V 1S3W 1U71 1U72 1YHO 2C2S 2C2T 2DHF 3EIG 3F8Y 3F8Z 3F91 3FS6 3GHC 3GHV 3GHW
Structure:
3GHW

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----
----

References: